Sintilimab in Adenocarcinoma of Lung: NCT07748325 Clinical Landscape Report 2026
Explore the PatSnap Life Sciences MCP marketplace
This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.
Data snapshot: 18 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.
Phase 2
Clinical phase
Recruiting
Recruitment status
100
Planned enrollment
2027-12-30
Primary-completion proxy
Executive view
NCT07748325 evaluates Sintilimab in Adenocarcinoma of Lung. The disclosed sponsor is Sichuan University, the design is Interventional, and the geographic footprint is China. The first listed primary endpoint is 18-Month Disease-Free Survival Rate, assessed over At 18 months after definitive surgery.
The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.
PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.
How the MCP evidence stack was assembled
Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07748325 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Adenocarcinoma of Lung landscape. Drug & Asset MCP drug_fetch was queried for Sintilimab, while Company & Deal Intelligence MCP organization_fetch was queried for Sichuan University.
This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Readout proxy |
|---|---|---|---|---|---|---|
| NCT07748325 | Sintilimab | Phase 2 / Recruiting | Sichuan University | China | 18-Month Disease-Free Survival Rate At 18 months after definitive surgery | 2027-12-30 |
| NCT07746388 | Cemiplimab-RWLC | Phase 2 / Not yet recruiting | University of Maryland Baltimore | Geography not reported | Major pathologic response (MPR) At time of surgery | 2030-09-01 |
| NCT07744529 | Amivantamab-VMJM | Phase 1/2 / Recruiting | Sponsor not reported | China | Number of Participants with Treatment-Related Adverse Events as Assessed by CTCAE v5.0" 2 year | 2028-05-28 |
| NCT07744698 | Paclitaxel | Phase 4 / Recruiting | Anhui Provincial Cancer Hospital | China | Progression-Free Survival (PFS) First dose up to approximately 24 months | 2029-06-01 |
| NCT07714304 | JS-212 | Not Applicable / Not yet recruiting | Shanghai Junshi Biosciences Co., Ltd. | China | ORR up to 3 years | 2026-11-13 |
The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.
Reproduce the trial-to-asset workflow with PatSnap MCP
Protocol design and endpoint interpretation
NCT07748325 is a Phase 2, recruiting study with 100 planned participants. Allocation is Randomized, masking is None (Open Label), and the intervention model is Parallel Assignment.
The primary endpoint is “18-Month Disease-Free Survival Rate” over “At 18 months after definitive surgery.” The retrieved endpoint description is: The Kaplan-Meier estimated proportion of participants who are alive and free from local recurrence, regional recurrence, distant metastasis, or death from any cause at 18 months after definitive surgery. Participants without a documented disease-free survival event will be censored at the date of their last disease assessment..
Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 100 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.
No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.
Indexed readouts in the surrounding landscape
5 recent result records were selected as contextual evidence for Adenocarcinoma of Lung. These records do not establish direct evidence for NCT07748325 unless the registration number matches.
A Phase III Prospective Double Blind Placebo Controlled Randomized Study of Adjuvant MEDI4736 In Completely Resected Non-Small Cell Lung Cancer
Phase 3; n=1415; Compare Disease Free Survival (DFS) for Patients With NSCLC That is PD-L1 Expression TC ≥ 25% and Patients Without EGFR Exon 21 L858R Mutation or Exon 19 Deletions or ALK Gene Rearrangements(Median) = 60.2 DFS time in months. (95% Confidence Interval, 47.7 - NA); Compare Disease Free Survival (DFS) for Patients With NSCLC That is PD-L1 Expression TC ≥ 25% and Patients Without EGFR Exon 21 L858R Mutation or Exon 19 D… Source: https://clinicaltrials.gov/ct2/show/results/NCT02273375
ASTRES: A Phase 2, Single-Arm Study of Atezolizumab in Locally Advanced, Unresectable, Stage III, Non-Small Cell Lung Cancer
Phase 2; n=127; PFS(IRF-assessed 12-month) = 54.9 % ( 46.0 - 63.7) Source: https://cattendee.abstractsonline.com/meeting/21487/Session/124
First-Line Chemoimmunotherapy and Chemotherapy Outcomes in RET Fusion-Positive Lung Cancer Patients in LIBRETTO-431
Phase 3; n=102; mPFS: P-Value = 0.8; mPFS = 11.0 month ( 11.0 - 17.0) Source: https://cattendee.abstractsonline.com/meeting/21487/Session/187
Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.
Asset and sponsor context
Sintilimab is indexed as Monoclonal antibody with PD-1 biology and a global stage of Approved. The asset profile lists Eli Lilly & Co. as an originator or developer.
Sichuan University is indexed in China with the website http://www.scu.edu.cn. Sichuan University is a university that is devoted to quality teaching, learning, research, and to serving as an innovation engine. The record lists 281 development-stage drug assets.
For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.
Development white space
- Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
- Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
- Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
- Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
- Sequencing white space. Clarify whether Sintilimab is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.
White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.
Strategic implications and next readouts
For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.
For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.
Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.
Source trail and bottom line
Anchor trial: NCT07748325
Protocol source: https://clinicaltrials.gov/study/NCT07748325
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 18 September 2026.
Sintilimab in Adenocarcinoma of Lung is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes 18-Month Disease-Free Survival Rate and 2027-12-30 the leading decision points.
Build and refresh clinical landscape reports with PatSnap MCP
