HDM-2017 in Advanced Colorectal Adenocarcinoma: NCT07805551 Clinical Landscape Report 2026
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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.
Data snapshot: 16 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.
Phase 1/2
Clinical phase
Recruiting
Recruitment status
220
Planned enrollment
2030-08-01
Primary-completion proxy
Executive view
NCT07805551 evaluates HDM-2017 in Advanced Colorectal Adenocarcinoma. The disclosed sponsor is Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd., the design is Interventional, and the geographic footprint is China. The first listed primary endpoint is Maximum Tolerated Dose (MTD), assessed over 30 days after the last dose of IMP.
The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.
PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.
How the MCP evidence stack was assembled
Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07805551 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Advanced Colorectal Adenocarcinoma landscape. Drug & Asset MCP drug_fetch was queried for HDM-2017, while Company & Deal Intelligence MCP organization_fetch was queried for Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd..
This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Readout proxy |
|---|---|---|---|---|---|---|
| NCT07805551 | HDM-2017 | Phase 1/2 / Recruiting | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | China | Maximum Tolerated Dose (MTD) 30 days after the last dose of IMP | 2030-08-01 |
| NCT07807800 | DES-1357 | Phase 1/2 / Not yet recruiting | D.E. Shaw Research LLC | Geography not reported | Part 1: Number of Participants With Dose-Limiting Toxicities (DLTs) Part 1: Cycle 1 (Cycle length=21 days) | 2028-07-02 |
| NCT07808151 | Pembrolizumab | Phase 2 / Not yet recruiting | Solstice Oncology, Inc. | Netherlands, Belgium, United States, United Kingdom, Italy, Spain | Major Pathologic Response (MPR) rate by Blinded Independent Pathologic Review (BIPR) Assessed from surgical resection specimen (surgery occurs Day 42-Day… | 2029-09-30 |
| NCT07808177 | 177Lu-FAP-VG11 | Early Phase 1 / Recruiting | Shandong First Medical University Affiliated Tumor Hospital (Shandong Cancer Research Institute Shandong Tumor Hospital) | China | Dose-Limiting Toxicities (DLT) Through study completion, assessed up to 2 years. | 2027-05-06 |
| NCT07805369 | DEM301 | Phase 1 / Not yet recruiting | DEM BioPharma, Inc. | Geography not reported | Incidence of Dose-Limiting Toxicities (DLTs) 21 Days | 2028-09-01 |
The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.
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Protocol design and endpoint interpretation
NCT07805551 is a Phase 1/2, recruiting study with 220 planned participants. Allocation is Non-Randomized, masking is None (Open Label), and the intervention model is Single Group Assignment.
The primary endpoint is “Maximum Tolerated Dose (MTD)” over “30 days after the last dose of IMP.” The retrieved endpoint description is: The MTD will be determined using DLTs.
Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 220 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.
No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.
Indexed readouts in the surrounding landscape
5 recent result records were selected as contextual evidence for Advanced Colorectal Adenocarcinoma. These records do not establish direct evidence for NCT07805551 unless the registration number matches.
Randomized phase-II trial of surufatinib plus FOLFOX/FOLFIRI versus FOLFOXIRI as second-line therapy for metastatic colorectal cancer
Phase 2; n=57; ORR = 39.3 % ( 21.5 - 59.4); ORR = 35.7 % ( 18.6 - 55.9) Source: https://pubmed-ncbi-nlm-nih-gov.libproxy1.nus.edu.sg/42421558/
Phase II Study of Regorafenib in Good Performance Status Patients With Newly Diagnosed Metastatic Colorectal Adenocarcinoma
Phase 2; n=11; No numerical result field reported Source: https://clinicaltrials.gov/ct2/show/results/NCT02023333
Aspirin for cancer prevention in individuals with Lynch syndrome: first results from the CaPP3 multicentre, randomised, double-blind, non-inferiority trial
Phase 3; n=1879; Lynch syndrome cancers = 75.0 Participant ; Lynch syndrome cancers = 57.0 Participant Source: https://pubmed-ncbi-nlm-nih-gov.libproxy1.nus.edu.sg/42425127/
Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.
Asset and sponsor context
HDM-2017 is indexed as Antibody drug conjugate (ADC) with CDH17 x Top I biology and a global stage of Phase 1/2. The asset profile lists Huadong Medicine Co., Ltd. as an originator or developer.
Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. is indexed in China with the website https://www.eastchinapharm.com. Manufactures and distributes pharmaceutical products The record lists 48 development-stage drug assets.
For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.
Development white space
- Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
- Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
- Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
- Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
- Sequencing white space. Clarify whether HDM-2017 is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.
White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.
Strategic implications and next readouts
For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.
For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.
Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.
Source trail and bottom line
Anchor trial: NCT07805551
Protocol source: https://clinicaltrials.gov/study/NCT07805551
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 16 September 2026.
HDM-2017 in Advanced Colorectal Adenocarcinoma is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Maximum Tolerated Dose (MTD) and 2030-08-01 the leading decision points.
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