Roxadustat NCT07786168 Clinical Landscape 2026

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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.

Data snapshot: 16 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.

Not Applicable

Clinical phase

Completed

Recruitment status

64

Planned enrollment

2026-06-20

Primary-completion proxy

Executive view

NCT07786168 evaluates Roxadustat in Anemia. The disclosed sponsor is Shaikh Zayed Hospital, the design is Interventional, and the geographic footprint is Pakistan. The first listed primary endpoint is Change in Hemoglobin Level From Baseline to 3 Months, assessed over Baseline to 3 months.

The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.

PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.

How the MCP evidence stack was assembled

Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07786168 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Anemia landscape. Drug & Asset MCP drug_fetch was queried for Roxadustat, while Company & Deal Intelligence MCP organization_fetch was queried for Shaikh Zayed Hospital.

This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.

Trial landscape table

Trial	Asset / intervention	Phase / status	Sponsor	Geography	Primary endpoint	Readout proxy
NCT07786168	Roxadustat	Not Applicable / Completed	Shaikh Zayed Hospital	Pakistan	Change in Hemoglobin Level From Baseline to 3 Months Baseline to 3 months	2026-06-20
NCT07786571	Dorzagliatin	Not Applicable / Not yet recruiting	Sun Yat-Sen University	China	Change in Time in Range (TIR, 3.9-10.0 mmol/L) from baseline to Week 14 Baseline to Week 14	2029-03-01
NCT07784452	Recombinant meningococcal group B vaccine (Sanroad Biological Products)	Not Applicable / Completed	Jinnah Hospital Lahore	Pakistan	Proportion of Participants Achieving Seroprotection (Anti-HBs Titer ≥10 mIU/mL) 30 days after completion of the assigned vaccination schedule (Month…	2026-07-20
NCT07781020	Mecobalamin	Not Applicable / Completed	Jinnah Hospital Lahore	Pakistan	Change in Serum Vitamin B12 Level from Baseline to Week 5 Baseline and Week 5 (one week after completion of the 4-week interven…	2026-05-22
NCT07775482	Finerenone	Not Applicable / Not yet recruiting	Sponsor not reported	Canada	Recruitment success 2 years from first participant recruited	2029-01-01

The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.

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Protocol design and endpoint interpretation

NCT07786168 is a Not Applicable, completed study with 64 planned participants. Allocation is Randomized, masking is None (Open Label), and the intervention model is Parallel Assignment.

The primary endpoint is “Change in Hemoglobin Level From Baseline to 3 Months” over “Baseline to 3 months.” The retrieved endpoint description is: Change in hemoglobin was calculated as the hemoglobin level at the end of the three-month treatment period minus the baseline hemoglobin level. Hemoglobin was measured in g/dL..

Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 64 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.

The protocol identifies Recombinant RSV vaccine (Chengda Bio) as control therapy. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.

Indexed readouts in the surrounding landscape

5 recent result records were selected as contextual evidence for Anemia. These records do not establish direct evidence for NCT07786168 unless the registration number matches.

Hydroxychloroquine for the Management of CVD in CKD

Phase 2; n=100; Baseline(Mean) = 1674.38 mm3 (Standard Deviation, 439.89); Baseline(Mean) = 1498.57 mm3 (Standard Deviation, 341.54) Source: https://clinicaltrials.gov/ct2/show/results/NCT03636152

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Quarterly and Monthly TOUR006 in Participants With Chronic Kidney Disease and Elevated High-Sensitivity C…

Phase 2; n=143; Time-Averaged Percent Change From Baseline in High-Sensitivity C-Reactive Protein (Hs-CRP) Through Day 90(Median) = -14.8 Time-Averaged Percent Change in hsCRP (Inter-Quartile Range, -35.8 to 17.4); Time-Averaged Percent Change From Baseline in High-Sensitivity C-Reactive Protein (Hs-CRP) Through Day 90(Median): Median Difference (Net) = -59.817(95% CI, -79.690 to -39.943), P-Value = <0.0001; Median Difference (Net)… Source: https://clinicaltrials.gov/ct2/show/results/NCT06362759

Phase III Multicenter Open-label Randomized Clinical Trial Comparing Everolimus and Low Dose Tacrolimus to Tacrolimus and Mycophenolate Mofetil at 6 mo Post-Transplant to Prevent…

Phase 3; n=211; EFFICACY: MATE-3 Score(Mean) = 0.9 Scores on a scale (Standard Deviation, 2.2); EFFICACY: MATE-3 Score(Mean): Mean Difference (Net) = -0.32(95% CI, -0.90 to 0.20), P-Value = 0.16 Source: https://clinicaltrials.gov/ct2/show/results/NCT03386539

Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.

Asset and sponsor context

Roxadustat is indexed as Small molecule drug with HIF-PHs biology and a global stage of Approved. The asset profile lists Kyntra Bio, Inc. as an originator or developer.

Shaikh Zayed Hospital is indexed in Pakistan with the website http://szmc.org.pk/hospital_departments.aspx. The organization record is used to resolve sponsor identity. The record lists an unreported number of development-stage drug assets.

For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.

Development white space

Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
Sequencing white space. Clarify whether Roxadustat is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.

White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.

Strategic implications and next readouts

For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.

For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.

Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.

Source trail and bottom line

Anchor trial: NCT07786168
Protocol source: https://clinicaltrials.gov/study/NCT07786168
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 16 September 2026.

Roxadustat in Anemia is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Change in Hemoglobin Level From Baseline to 3 Months and 2026-06-20 the leading decision points.

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