Clear Cell Renal Cell Carcinoma Clinical Landscape Report 2026: Trials, Readouts and White Space
Turn fragmented clinical intelligence into a decision-ready landscape. This report was assembled with PatSnap MCP Servers for Clinical Trials, Drug & Asset, and Company & Deal Intelligence. Explore the PatSnap MCP Marketplace to reproduce the workflow in your own AI research stack.
Data snapshot: 16 July 2026. This report is a strategic research view, not medical advice. Trial status and timing can change; confirm records before making development or investment decisions.
Executive view
Clear Cell Renal Cell Carcinoma remains an active clinical development field. The competitive center of gravity is moving toward biomarker-defined populations, rational combinations, earlier treatment lines and evidence that can survive active-comparator scrutiny. The PatSnap evidence set used here contains 862 matched trial records and 2,423 indexed result records before the decision-focused sample below was selected.
How PatSnap MCP built this report
The workflow used Clinical Trials MCP search to define the landscape, then clinical_trial_fetch to retrieve trial design, phase, status, sponsor, geography, endpoints and timing. It separately called clinical_trial_result_fetch for indexed readouts. Drug & Asset drug_fetch supplied target and global development status, while Company & Deal Intelligence organization_fetch supplied sponsor context. This keeps trial-, asset- and company-level claims distinct and traceable.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Expected readout |
|---|---|---|---|---|---|---|
| NCT07697417 | Intervention not normalized | Not Applicable; Active, not recruiting | Second Hospital of Tianjin Medical University | China | Modified Pentafecta Achievement After Partial Nephrectomy (From the date of partial nephrectomy to the last available postoperative…) | 2026-05-30 |
| NCT07691476 | Pembrolizumab + Zanzalintinib | Phase 2; Not yet recruiting | Yonsei University | Geography not listed | Overall Response Rate (Preoperatively, up to 22 weeks) | 2028-10-31 |
| CTR20262632 | Anlotinib Dihydrochloride | Not Applicable; 进行中 （尚未招募） | Kunshan Rotam Reddy Pharmaceutical Co. Ltd. | China | (0时至给药后360 h) | Timing not listed |
| NCT07689240 | Pembrolizumab | Phase 3; Not yet recruiting | National Cancer Institute | Geography not listed | Disease-free survival (DFS) (From randomization to first documented local recurrence, distant metastasis,…) | 2032-01-01 |
The table is designed for competitive decisions: endpoint selection, geographic reach and readout timing appear beside phase and sponsor. Phase alone does not reveal evidence maturity; a small study may answer a near-term biomarker question while a large pivotal program can leave a multi-year readout gap.
What indexed results say
- Phase II Study of CC-5013 in Patients With Advanced Renal Cell Carcinoma (RCC) (Phase 2): the indexed record reports ORR = 3 Participants; -; -.
- Discovery of Casdatifan, Part II: A Potent and Orally Bioavailable Inhibitor of Hypoxia Inducible Factor-2α (Phase 3): the indexed record reports AE(Grade ≥3) = 55.0 %.
- A Phase 1b/2a Dose-escalation and Safety/Efficacy Evaluation Study of Pexa-Vec (Thymidine Kinase-Deactivated Vaccinia Virus Plus GM-CSF) in Combination With Cemiplimab (REGN2810; Anti-PD-1) in Patients With Metastatic or Unresectable Renal Cell Carcinoma (RCC) (Phase 1/2): the indexed record reports Grade 3 or greater AEs = 12 Participants; Grade 3 or greater AEs = 7 Participants; -.
Cross-trial comparisons require caution. Population, prior therapy, baseline risk, endpoint definition, follow-up and analysis set can all change the apparent signal. The strategic value lies in identifying what each readout resolves—and which uncertainty remains.
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Asset and sponsor context
PatSnap Drug & Asset records add mechanism and global development status for the sampled programs, including Pembrolizumab (Approved; PD-1), Zanzalintinib (NDA/BLA; AXL x MerTK x TYRO3 x VEGFR1 x c-Met), Anlotinib Dihydrochloride (Approved; FGFRs x VEGFR1 x VEGFR2 x VEGFR3 x c-Kit). Company & Deal Intelligence records identify sponsor context for Second Hospital of Tianjin Medical University, Yonsei University, Kunshan Rotam Reddy Pharmaceutical Co. Ltd., National Cancer Institute. Together, those layers show whether a study sits inside a scaled portfolio, an emerging specialist strategy or an academic development path.
Where the white space is
- Prospective biomarker thresholds that predict benefit rather than simply confirm target presence.
- Randomized sequencing evidence after prior targeted therapy, immunotherapy or antibody–drug conjugates.
- Endpoints that connect response depth with durability, quality of life and overall survival.
- Geographically broader development programs with harmonized molecular testing.
Strategic implications
For sponsors, differentiation is more credible when the evidence package resolves a known decision gap: an active comparator, a better-defined responder population, a safer or easier delivery model, a clinically meaningful outcome, or a defensible sequencing strategy. Business-development teams can use the same landscape to separate crowded mechanisms from differentiated evidence architectures. Investors should track endpoint maturity and operational feasibility alongside nominal phase.
What to monitor next
Track status changes, protocol amendments, primary-completion dates, newly indexed results, ownership changes and multinational expansion. Re-run the MCP queries on a schedule and compare deltas. Pay particular attention when a program moves from a surrogate endpoint to a clinical outcome or when a specialist sponsor adds a scaled development partner.
Bottom line
Clear Cell Renal Cell Carcinoma has meaningful clinical activity and equally meaningful evidence gaps. A useful landscape connects trial design, results, mechanism and sponsor rather than listing studies in isolation.
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