Cold Agglutinin Disease Clinical Landscape Report 2026: Trials, Readouts and White Space
Turn fragmented clinical intelligence into a decision-ready landscape. This report was assembled with PatSnap MCP Servers for Clinical Trials, Drug & Asset, and Company & Deal Intelligence. Explore the PatSnap MCP Marketplace to reproduce the workflow in your own AI research stack.
Data snapshot: 16 July 2026. This report is a strategic research view, not medical advice. Trial status and timing can change; confirm records before making development or investment decisions.
Executive view
Cold Agglutinin Disease remains an active clinical development field. One-time and precision therapies are raising the efficacy ceiling, but durability, manufacturing, small-population evidence and long-term safety remain decisive constraints. The PatSnap evidence set used here contains 89 matched trial records and 60 indexed result records before the decision-focused sample below was selected.
How PatSnap MCP built this report
The workflow used Clinical Trials MCP search to define the landscape, then clinical_trial_fetch to retrieve trial design, phase, status, sponsor, geography, endpoints and timing. It separately called clinical_trial_result_fetch for indexed readouts. Drug & Asset drug_fetch supplied target and global development status, while Company & Deal Intelligence organization_fetch supplied sponsor context. This keeps trial-, asset- and company-level claims distinct and traceable.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Expected readout |
|---|---|---|---|---|---|---|
| ChiCTR2600128081 | Intervention not normalized | Not Applicable; Recruiting | Sponsor not listed | China | Incidence of Rh-HDFN (within 72 hours after delivery) | 2025-12-31 |
| NCT07689604 | Intervention not normalized | Early Phase 1; Not yet recruiting | Sponsor not listed | China | Incidence and severity of adverse events (Up to 28 days after META 10-19 infusion.) | 2027-05-01 |
| CTR20262511 | Intervention not normalized | Phase 1; 进行中 （尚未招募） | Guang Dong He Yuan Sheng Wu Yi Yao You Xian Gong Si; Juventas Cell Therapy Ltd. | China | (D28); (回输后M24) | Timing not listed |
| NCT07629596 | Arnovie101 | Early Phase 1; Recruiting | Sponsor not listed | China | Incidence of dose-limiting toxicity (DLT) (Up to 12 months); Incidence and severity of adverse event (AE) and serious adverse event (SAE) (Up to 12 months) | 2027-05-30 |
The table is designed for competitive decisions: endpoint selection, geographic reach and readout timing appear beside phase and sponsor. Phase alone does not reveal evidence maturity; a small study may answer a near-term biomarker question while a large pivotal program can leave a multi-year readout gap.
What indexed results say
- DIFFERENT DISEASES, DIFFERENT RESPONSES: TREATMENT OUTCOMES IN COLD AGGLUTININ DISEASE VS SYNDROME (Not Applicable): the indexed record reports remission = 50.0 %; remission = 58.0 %; remission = 14.0 %.
- SUTIMLIMAB IN PATIENTS WITH COLD AGGLUTININ DISEASE AND PRIOR RITUXIMAB EXPOSURE: A POST-HOC ANALYSIS OF THE PHASE 3 CADENZA STUDY (Phase 3): the indexed record reports Responder rate(at treatment assessment timepoint) = 7.7 %; Responder rate(at treatment assessment timepoint) = 83.3 %.
- ORELABRUTINIB FOR THE TREATMENT OF REFRACTORY/RELAPSED AUTOIMMUNE HAEMOLYTIC ANAEMIA/EVANS SYNDROME: RESULTS FROM AN OPEN-LABEL, PHASE 2 TRIAL (Phase 2): the indexed record reports AE = mild infections (upper respiratory tract infection, urinary tract infection, pneumonia, etc.), skin bruising, conjunctival hemorrhage, bone marrow suppression, and elevated glutamic-pyruvic transaminase or glutamic oxaloacetic transaminase levels. Only one patient stopped treatment due to skin bruising..
Cross-trial comparisons require caution. Population, prior therapy, baseline risk, endpoint definition, follow-up and analysis set can all change the apparent signal. The strategic value lies in identifying what each readout resolves—and which uncertainty remains.
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Asset and sponsor context
PatSnap Drug & Asset records add mechanism and global development status for the sampled programs, including Arnovie101 (Clinical; CD8). Company & Deal Intelligence records identify sponsor context for Guang Dong He Yuan Sheng Wu Yi Yao You Xian Gong Si, Juventas Cell Therapy Ltd.. Together, those layers show whether a study sits inside a scaled portfolio, an emerging specialist strategy or an academic development path.
Where the white space is
- Natural-history-aligned endpoints that remain interpretable in small heterogeneous cohorts.
- Long-term registries for durability, immunogenicity and delayed safety signals.
- Redosing, rescue and treatment-sequencing strategies after incomplete response.
- Access models that address diagnosis, manufacturing and global delivery.
Strategic implications
For sponsors, differentiation is more credible when the evidence package resolves a known decision gap: an active comparator, a better-defined responder population, a safer or easier delivery model, a clinically meaningful outcome, or a defensible sequencing strategy. Business-development teams can use the same landscape to separate crowded mechanisms from differentiated evidence architectures. Investors should track endpoint maturity and operational feasibility alongside nominal phase.
What to monitor next
Track status changes, protocol amendments, primary-completion dates, newly indexed results, ownership changes and multinational expansion. Re-run the MCP queries on a schedule and compare deltas. Pay particular attention when a program moves from a surrogate endpoint to a clinical outcome or when a specialist sponsor adds a scaled development partner.
Bottom line
Cold Agglutinin Disease has meaningful clinical activity and equally meaningful evidence gaps. A useful landscape connects trial design, results, mechanism and sponsor rather than listing studies in isolation.
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