Focal Segmental Glomerulosclerosis Clinical Landscape Report 2026: Trials, Readouts and White Space
Turn fragmented clinical intelligence into a decision-ready landscape. This report was assembled with PatSnap MCP Servers for Clinical Trials, Drug & Asset, and Company & Deal Intelligence. Explore the PatSnap MCP Marketplace to reproduce the workflow in your own AI research stack.
Data snapshot: 16 July 2026. This report is a strategic research view, not medical advice. Trial status and timing can change; confirm records before making development or investment decisions.
Executive view
Focal Segmental Glomerulosclerosis remains an active clinical development field. Development is moving beyond single surrogate measures toward integrated cardiometabolic, renal and clinical-outcome evidence, with convenience and persistence becoming major differentiators. The PatSnap evidence set used here contains 49 matched trial records and 65 indexed result records before the decision-focused sample below was selected.
How PatSnap MCP built this report
The workflow used Clinical Trials MCP search to define the landscape, then clinical_trial_fetch to retrieve trial design, phase, status, sponsor, geography, endpoints and timing. It separately called clinical_trial_result_fetch for indexed readouts. Drug & Asset drug_fetch supplied target and global development status, while Company & Deal Intelligence organization_fetch supplied sponsor context. This keeps trial-, asset- and company-level claims distinct and traceable.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Expected readout |
|---|---|---|---|---|---|---|
| NCT07614477 | Civorebrutinib | Phase 2; Recruiting | Everest Medicines Ltd. | China | Percentage change from baseline in 24-hour urine protein-to-creatinine ratio (UPCR) (Week24); Treatment-emergent adverse events (TEAEs) (Throughout the study period, up to Week 56) | 2028-12-31 |
| NCT07516964 | Intervention not normalized | Not Applicable; Recruiting | Sponsor not listed | United States, Mexico, Italy, Germany, Spain | Analysis of anti-nephrin antibody levels (From enrollment through 5 years of follow-up) | 2034-10-01 |
| JPRN-UMIN000060935 | Intervention not normalized | Not Applicable; 一般募集中/Open public recruiting | Kyorin University | Japan | 初発時および再発時の特発性ネフローゼ症候群患者の血清抗Crb2抗体価; Serum anti-Crb2 antibody titers in patients with idiopathic nephrotic syndrome at onset and relapse | 2027-12-31 |
| NCT07499700 | BAT-4406F | Phase 2/3; Recruiting | Bio-Thera Solutions, Ltd. | China | Effectiveness indicators (Phase II: 26 weeks; Phase III: 52 weeks) | 2030-10-26 |
The table is designed for competitive decisions: endpoint selection, geographic reach and readout timing appear beside phase and sponsor. Phase alone does not reveal evidence maturity; a small study may answer a near-term biomarker question while a large pivotal program can leave a multi-year readout gap.
What indexed results say
- A Single-center, Phase 2 Open-label Trial Evaluating the Efficacy and Safety of OBINUTUZUMAB in Treatment of Immunosuppression-dependent or Immunosuppression/Treatment-resistant Primary FSGS, or Contraindication/Patient Refusal to Take High Dose Corticosteroids (Phase 2): the indexed record reports Proteinuria at baseline(Median) = 10.7 g/d (Inter-Quartile Range, 7.5 - 13.7); -; -.
- The Use of Acthar (ACTH) in Patients With Focal Segmental Glomerulosclerosis (FSGS) Who Have Developed Chronic Kidney Disease Stage V (CKD) or End Stage Renal Disease (ESRD) and Are Undergoing a Renal Transplant (Phase 3): the indexed record reports -; Rate of Recurrence of FSGS as Seen in Renal Transplant Biopsies Proteinuria = 14 Participants; -.
- TRPC6 inhibition for the treatment of focal segmental glomerulosclerosis: a randomised, placebo-controlled, phase 2 trial of BI 764198 (Phase 2): the indexed record reports Proteinuria responses = 7.0 %; Proteinuria responses = 35.0 %; Proteinuria responses = 14.0 %.
Cross-trial comparisons require caution. Population, prior therapy, baseline risk, endpoint definition, follow-up and analysis set can all change the apparent signal. The strategic value lies in identifying what each readout resolves—and which uncertainty remains.
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Asset and sponsor context
PatSnap Drug & Asset records add mechanism and global development status for the sampled programs, including Civorebrutinib (Phase 2; BTK), BAT-4406F (NDA/BLA; CD20). Company & Deal Intelligence records identify sponsor context for Everest Medicines Ltd. (1952), Kyorin University, Bio-Thera Solutions, Ltd. (688177). Together, those layers show whether a study sits inside a scaled portfolio, an emerging specialist strategy or an academic development path.
Where the white space is
- Active-comparator trials on top of contemporary standard of care.
- Hard cardiovascular, kidney or liver outcomes linked to earlier biomarker change.
- Evidence in underrepresented populations and patients with multiple comorbidities.
- Durability, adherence and post-discontinuation outcomes.
Strategic implications
For sponsors, differentiation is more credible when the evidence package resolves a known decision gap: an active comparator, a better-defined responder population, a safer or easier delivery model, a clinically meaningful outcome, or a defensible sequencing strategy. Business-development teams can use the same landscape to separate crowded mechanisms from differentiated evidence architectures. Investors should track endpoint maturity and operational feasibility alongside nominal phase.
What to monitor next
Track status changes, protocol amendments, primary-completion dates, newly indexed results, ownership changes and multinational expansion. Re-run the MCP queries on a schedule and compare deltas. Pay particular attention when a program moves from a surrogate endpoint to a clinical outcome or when a specialist sponsor adds a scaled development partner.
Bottom line
Focal Segmental Glomerulosclerosis has meaningful clinical activity and equally meaningful evidence gaps. A useful landscape connects trial design, results, mechanism and sponsor rather than listing studies in isolation.
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