Heart Failure with Preserved Ejection Fraction Clinical Landscape Report 2026: Trials, Readouts and White Space
Turn fragmented clinical intelligence into a decision-ready landscape. This report was assembled with PatSnap MCP Servers for Clinical Trials, Drug & Asset, and Company & Deal Intelligence. Explore the PatSnap MCP Marketplace to reproduce the workflow in your own AI research stack.
Data snapshot: 16 July 2026. This report is a strategic research view, not medical advice. Trial status and timing can change; confirm records before making development or investment decisions.
Executive view
Heart Failure with Preserved Ejection Fraction remains an active clinical development field. Development is moving beyond single surrogate measures toward integrated cardiometabolic, renal and clinical-outcome evidence, with convenience and persistence becoming major differentiators. The PatSnap evidence set used here contains 371 matched trial records and 210 indexed result records before the decision-focused sample below was selected.
How PatSnap MCP built this report
The workflow used Clinical Trials MCP search to define the landscape, then clinical_trial_fetch to retrieve trial design, phase, status, sponsor, geography, endpoints and timing. It separately called clinical_trial_result_fetch for indexed readouts. Drug & Asset drug_fetch supplied target and global development status, while Company & Deal Intelligence organization_fetch supplied sponsor context. This keeps trial-, asset- and company-level claims distinct and traceable.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Expected readout |
|---|---|---|---|---|---|---|
| ChiCTR2600128169 | Intervention not normalized | Not Applicable; Not yet recruiting | Xiangya Hospital Central South University | China | Coronary perivascular fat attenuation index (FAI) (At baseline (single assessment, based on coronary CTA images already acquired…); Major adverse cardiovascular events (MACE) (Baseline, and at 6, 12, 18, and 24 months after enrollment (follow-up time…) | 2029-09-30 |
| ChiCTR2600128166 | Henagliflozein Proline | Phase not listed; Not yet recruiting | Xijing Hospital | China | Kansas City Cardiomyopathy Quality of Life Questionnaire Score | 2027-11-30 |
| NCT07701876 | Intervention not normalized | Not Applicable; Recruiting | Sponsor not listed | China | Change in Left Ventricular Ejection Fraction (LVEF) from Baseline to 12 Months (Baseline and 12 Months) | 2028-08-31 |
| NCT07696975 | Intervention not normalized | Not Applicable; Not yet recruiting | V-Wave Ltd. | Geography not listed | Primary Safety (From enrollment at the intervention procedure through 30 days.); Primary Effectiveness (The Primary analysis will be conducted after the final enrolled participant…) | 2029-03-31 |
The table is designed for competitive decisions: endpoint selection, geographic reach and readout timing appear beside phase and sponsor. Phase alone does not reveal evidence maturity; a small study may answer a near-term biomarker question while a large pivotal program can leave a multi-year readout gap.
What indexed results say
- SOTA-P-CARDIA Trial: A Randomized Trial of Sotagliflozin in HFpEF Patients Without Diabetes (Phase 4): the indexed record reports Changes in Left Ventricular Mass in CMRI(Mean) = 5.7 grams (95% Confidence Interval, 2.1 - 9.2); Changes in Left Ventricular Mass in CMRI(Mean) = -8.6 grams (95% Confidence Interval, -11.9 to -5.3); -.
- Cost-effectiveness of finerenone in heart failure with mildly reduced or preserved ejection fraction – Insights from FINEARTS-HF (Phase 3): the indexed record reports ICER(32-month, US) = 473.0 USD.
- A Bayesian analysis of finerenone in heart failure with mildly reduced and preserved ejection fraction: a pre-specified analysis of FINEARTS-HF (Phase 3): the indexed record reports all-cause mortality: HR = 0.94(95.0% CI, 0.83 - 1.06); all-cause mortality: HR = 0.94(95.0% CI, 0.83 - 1.06).
Cross-trial comparisons require caution. Population, prior therapy, baseline risk, endpoint definition, follow-up and analysis set can all change the apparent signal. The strategic value lies in identifying what each readout resolves—and which uncertainty remains.
Build a living clinical map: connect to PatSnap MCP Servers and combine trial design, result, asset and organization records without manually reconciling separate databases.
Asset and sponsor context
PatSnap Drug & Asset records add mechanism and global development status for the sampled programs, including Henagliflozein Proline (Approved; SGLT2). Company & Deal Intelligence records identify sponsor context for Xiangya Hospital Central South University, Xijing Hospital, V-Wave Ltd.. Together, those layers show whether a study sits inside a scaled portfolio, an emerging specialist strategy or an academic development path.
Where the white space is
- Active-comparator trials on top of contemporary standard of care.
- Hard cardiovascular, kidney or liver outcomes linked to earlier biomarker change.
- Evidence in underrepresented populations and patients with multiple comorbidities.
- Durability, adherence and post-discontinuation outcomes.
Strategic implications
For sponsors, differentiation is more credible when the evidence package resolves a known decision gap: an active comparator, a better-defined responder population, a safer or easier delivery model, a clinically meaningful outcome, or a defensible sequencing strategy. Business-development teams can use the same landscape to separate crowded mechanisms from differentiated evidence architectures. Investors should track endpoint maturity and operational feasibility alongside nominal phase.
What to monitor next
Track status changes, protocol amendments, primary-completion dates, newly indexed results, ownership changes and multinational expansion. Re-run the MCP queries on a schedule and compare deltas. Pay particular attention when a program moves from a surrogate endpoint to a clinical outcome or when a specialist sponsor adds a scaled development partner.
Bottom line
Heart Failure with Preserved Ejection Fraction has meaningful clinical activity and equally meaningful evidence gaps. A useful landscape connects trial design, results, mechanism and sponsor rather than listing studies in isolation.
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