CHT-105 NCT07517536 Clinical Landscape 2026

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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.

Data snapshot: 18 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.

Not Applicable

Clinical phase

Enrolling by invitation

Recruitment status

14

Planned enrollment

2028-01-01

Primary-completion proxy

Executive view

NCT07517536 evaluates CHT-105 in Lupus Nephritis. The disclosed sponsor is Nanjing Drum Tower Hospital, the design is Interventional, and the geographic footprint is China. The first listed primary endpoint is Safety of CHT105 Injection in Subjects with Refractory Lupus Nephritis, assessed over From enrollment to the end of treatment at 52 weeks.

The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.

PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.

How the MCP evidence stack was assembled

Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07517536 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Lupus Nephritis landscape. Drug & Asset MCP drug_fetch was queried for CHT-105, while Company & Deal Intelligence MCP organization_fetch was queried for Nanjing Drum Tower Hospital.

This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.

Trial landscape table

Trial	Asset / intervention	Phase / status	Sponsor	Geography	Primary endpoint	Readout proxy
NCT07517536	CHT-105	Not Applicable / Enrolling by invitation	Nanjing Drum Tower Hospital	China	Safety of CHT105 Injection in Subjects with Refractory Lupus Nephritis From enrollment to the end of treatment at 52 weeks	2028-01-01
NCT07516639	ISH-0613	Phase 1 / Not yet recruiting	Sunho (China) Biopharmaceutical Co., Ltd.	China	Number of participants with treatment-emergent adverse events as assessed by CTCAE v6.0 baseline through day 57	2026-12-31
NCT07512947	YK012	Phase 1 / Not yet recruiting	Wuhan Xiehe Hospital Tower	China	Incidence of Dose-Limiting Toxicities (DLTs) From first dose through Day 35	2028-03-30
NCT07507201	Universal allogeneic anti-CD19/BCMA CAR T-cells(The Children's Hospital of Zhejiang University School of Medicine)	Early Phase 1 / Recruiting	The Children's Hospital of Zhejiang University School of Medicine	China	Incidence of Dose-Limiting Toxicities (DLTs) Day 0 to Day 28 post-infusion.	2028-12-01
NCT07491900	CD19/CD20/FCGR trispecific antibody(Hinge Bio)	Phase 1 / Recruiting	Hinge Bio, Inc.	Australia	Number of participants experiencing treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs) Day 1, Day 8, Day 14, Day 29	2027-10-24

The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.

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Protocol design and endpoint interpretation

NCT07517536 is a Not Applicable, enrolling by invitation study with 14 planned participants. Allocation is N/A, masking is None (Open Label), and the intervention model is Single Group Assignment.

The primary endpoint is “Safety of CHT105 Injection in Subjects with Refractory Lupus Nephritis” over “From enrollment to the end of treatment at 52 weeks.” The retrieved endpoint description is: * Types and incidence of dose-limiting toxicities (DLTs); * Types, severity, and frequency of adverse events (AEs); * Incidence and grading of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS)..

Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 14 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.

No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.

Indexed readouts in the surrounding landscape

5 recent result records were selected as contextual evidence for Lupus Nephritis. These records do not establish direct evidence for NCT07517536 unless the registration number matches.

A PHASE 2, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE CLINICAL EFFECT, PHARMACODYNAMIC, PHARMACOKINETIC AND SAFETY PROFILE OF PF 06823859 IN A…

Phase 2; n=8; Change From Baseline in Type 1 Interferon (IFN) Gene Signature (GS) Score in Lesional Skin at Week 12(Least Squares Mean): Least Square Mean Difference = 0.5(90% CI, -3.7 to 4.6), P-Value = 0.8243; Change From Baseline in Type 1 Interferon (IFN) Gene Signature (GS) Score in Lesional Skin at Week 12(Least Squares Mean): Least Square Mean Difference = 0.5(90% CI, -3.7 to 4.6), P-Value = 0.8243 Source: https://clinicaltrials.gov/ct2/show/results/NCT05879718

A Phase 2a, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of MK-6194 in Adult Participants With Systemic Lupus Erythematosus

Phase 2; n=149; Number of Participants Achieving Systemic Lupus Erythematosus Responder Index (SRI-4) Response at Week 28 = 10 Participants ; Number of Participants Achieving Systemic Lupus Erythematosus Responder Index (SRI-4) Response at Week 28 = 15 Participants Source: https://clinicaltrials.gov/ct2/show/results/NCT06161116

Dapagliflozin in lupus nephritis: renal and hematologic outcomes from a randomized controlled trial

Phase 2; n=79; eGFR = -2.0 ml/min/1.73 m2 Source: https://pubmed-ncbi-nlm-nih-gov.libproxy1.nus.edu.sg/42549085/

Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.

Asset and sponsor context

CHT-105 is indexed as CAR-T with CD19 x CD70 biology and a global stage of Clinical. The asset profile lists Nanjing Drum Tower Hospital as an originator or developer.

Nanjing Drum Tower Hospital is indexed in China with the website http://www.njglyy.com. Nanjing Drum Tower Hospital specializes in training and diganosis treatment. The record lists 25 development-stage drug assets.

For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.

Development white space

Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
Sequencing white space. Clarify whether CHT-105 is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.

White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.

Strategic implications and next readouts

For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.

For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.

Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.

Source trail and bottom line

Anchor trial: NCT07517536
Protocol source: https://clinicaltrials.gov/study/NCT07517536
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 18 September 2026.

CHT-105 in Lupus Nephritis is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Safety of CHT105 Injection in Subjects with Refractory Lupus Nephritis and 2028-01-01 the leading decision points.

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