Semaglutide (Novo Nordisk) in Metabolic Dysfunction Associated Steatohepatitis: NCT06764056 Clinical Landscape Report 2026
Explore the PatSnap Life Sciences MCP marketplace
This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.
Data snapshot: 18 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.
Not Applicable
Clinical phase
Not yet recruiting
Recruitment status
120
Planned enrollment
2026-05-01
Primary-completion proxy
Executive view
NCT06764056 evaluates Semaglutide (Novo Nordisk) in Metabolic Dysfunction Associated Steatohepatitis. The disclosed sponsor is Institut universitaire de cardiologie et de pneumologie, the design is Interventional, and the geographic footprint is Canada. The first listed primary endpoint is Liver Steatosis, assessed over From enrollment to the end of the clinical trial at 12 months (for 4 visits).
The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.
PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.
How the MCP evidence stack was assembled
Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT06764056 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Metabolic Dysfunction Associated Steatohepatitis landscape. Drug & Asset MCP drug_fetch was queried for Semaglutide (Novo Nordisk), while Company & Deal Intelligence MCP organization_fetch was queried for Institut universitaire de cardiologie et de pneumologie.
This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Readout proxy |
|---|---|---|---|---|---|---|
| NCT06764056 | Semaglutide (Novo Nordisk) | Not Applicable / Not yet recruiting | Institut universitaire de cardiologie et de pneumologie | Canada | Liver Steatosis From enrollment to the end of the clinical trial at 12 months (for 4… | 2026-05-01 |
| NCT07214870 | NNC-4005-0001 | Phase 1 / Recruiting | Novo Nordisk A/S | Canada | Number of Treatment-emergent adverse event (TEAEs) From dosing (day 1) until compeletion of end of study (EOS) visit on… | 2027-05-14 |
| NCT07198386 | CS-060380 | Phase 2 / Recruiting | Cascade Pharmaceuticals, Inc. | China | MRI-PDFF D85 | 2026-07-24 |
| NCT07185932 | Rifaximin | Early Phase 1 / Recruiting | Shanghai Changzheng Hospital | China | The change in liver fat content measured by MRI at 24 weeks of treatment. From enrollment to the end of treatment at 24 weeks | 2027-12-31 |
| NCT07180745 | Atorvastatin Calcium | Phase 4 / Not yet recruiting | Badr University In Cairo | Egypt | The controlled attenuation parameter (CAP). After 3 months | 2026-02-01 |
The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.
Reproduce the trial-to-asset workflow with PatSnap MCP
Protocol design and endpoint interpretation
NCT06764056 is a Not Applicable, not yet recruiting study with 120 planned participants. Allocation is Randomized, masking is None (Open Label), and the intervention model is Parallel Assignment.
The primary endpoint is “Liver Steatosis” over “From enrollment to the end of the clinical trial at 12 months (for 4 visits).” The retrieved endpoint description is: Transient elastography is an ultrasound-based modality that is non-invasive and measures the degree of steatosis with the controlled attenuation parameter (CAP; dB/m) and liver stiffness (kPa).This method will be used at each visit to follow the progression and the efficiency of the interventions. The following ranges will be use to classify hepatic steatosis based on CAP (dB/m) (specific to FibroScan®): S0 (\ 337)..
Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 120 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.
No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.
Indexed readouts in the surrounding landscape
5 recent result records were selected as contextual evidence for Metabolic Dysfunction Associated Steatohepatitis. These records do not establish direct evidence for NCT06764056 unless the registration number matches.
A Placebo-controlled, Proof-of-concept Study to Evaluate the Safety and Efficacy of Lanifibranor Alone and in Combination With the Sodium-glucose Transport Protein 2 (SGLT2) Inhib…
Phase 2; n=39; Absolute Change in HbA1c(Least Squares Mean) = 0.16 percentage of glycosylated hemoglobin (95% Confidence Interval, -0.32 to 0.63); Absolute Change in HbA1c(Least Squares Mean) = -1.11 percentage of glycosylated hemoglobin (95% Confidence Interval, -1.6 to -0.62) Source: https://clinicaltrials.gov/ct2/show/results/NCT05232071
Role of Lisinopril in Preventing The Progression of Non-Alcoholic Fatty Liver Disease (NAFLD): Relief-NAFLD
Phase 2; n=35; Pre-Treatment(Mean) = 48 ng/mL (Standard Deviation, 17) Source: https://clinicaltrials.gov/ct2/show/results/NCT04550481
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steato…
Phase 2; n=213; ADR = 10 Participants ; ADR = 8 Participants Source: https://clinicaltrials.gov/ct2/show/results/NCT05039450
Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.
Asset and sponsor context
Semaglutide (Novo Nordisk) is indexed as Recombinant polypeptide with GLP-1R biology and a global stage of Approved. The asset profile lists Novo Nordisk A/S as an originator or developer.
Institut universitaire de cardiologie et de pneumologie is indexed in Canada with the website https://iucpq.qc.ca/en. Institut Universitaire de Cardiologie et de Pneumologie de Quebec offers specialized care in the treatment of cardiorespiratory diseases. The record lists an unreported number of development-stage drug assets.
For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.
Development white space
- Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
- Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
- Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
- Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
- Sequencing white space. Clarify whether Semaglutide (Novo Nordisk) is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.
White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.
Strategic implications and next readouts
For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.
For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.
Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.
Source trail and bottom line
Anchor trial: NCT06764056
Protocol source: https://clinicaltrials.gov/study/NCT06764056
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 18 September 2026.
Semaglutide (Novo Nordisk) in Metabolic Dysfunction Associated Steatohepatitis is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Liver Steatosis and 2026-05-01 the leading decision points.
Build and refresh clinical landscape reports with PatSnap MCP
