TolDC(University Hospital Antwerp) in Multiple Sclerosis, Chronic Progressive: NCT07020715 Clinical Landscape Report 2026
Explore the PatSnap Life Sciences MCP marketplace
This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.
Data snapshot: 15 October 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.
Phase 2
Clinical phase
Not yet recruiting
Recruitment status
not reported
Planned enrollment
2029-09-30
Primary-completion proxy
Executive view
NCT07020715 evaluates TolDC(University Hospital Antwerp) in Multiple Sclerosis, Chronic Progressive. The disclosed sponsor is UZA, the design is Interventional, and the geographic footprint is Belgium, Spain. The first listed primary endpoint is Efficacy (Change in EDSS score), assessed over 62 weeks.
The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.
PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.
How the MCP evidence stack was assembled
Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07020715 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Multiple Sclerosis, Chronic Progressive landscape. Drug & Asset MCP drug_fetch was queried for TolDC(University Hospital Antwerp), while Company & Deal Intelligence MCP organization_fetch was queried for UZA.
This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Readout proxy |
|---|---|---|---|---|---|---|
| NCT07020715 | TolDC(University Hospital Antwerp) | Phase 2 / Not yet recruiting | UZA | Belgium, Spain | Efficacy (Change in EDSS score) 62 weeks | 2029-09-30 |
| NCT07138833 | Dimethyl fumarate | Phase 4 / Not yet recruiting | Qilu Pharmaceutical Co., Ltd. | Geography not reported | Annualized Relapse Rate at Week 48 48 weeks | 2028-04-01 |
| NCT07139743 | Obecabatagene autoleucel | Phase 1 / Recruiting | Autolus Ltd. | United States, United Kingdom, Spain | Percentage of participants receiving obe-cel who experience dose-limiting toxicities (DLTs)) Up to Day 28 | 2029-08-15 |
| LBCTR2020030186 | Ocrelizumab | Phase 3 / Complete | Sponsor not reported | Lebanon, Bosnia and Herzegovina, Brazil, Canada, Colombia, Costa Rica, Czechia, Denmark, Egypt, France, Guatemala, Hungary, Ireland, Italy, Mexico, Morocco, Netherlands, Panama, Poland, Russia, Spain, United Arab Emirates, United States | Timing not reported | |
| NCT07085507 | VT-7208 | Phase 1/2 / Recruiting | Vidya Therapeutics, Inc. | Australia | Incidence, nature, and severity of treatment emergent adverse events (TEAEs) and serious adverse events (SAEs) of VT720… Up to 8 days | 2026-10-30 |
The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.
Reproduce the trial-to-asset workflow with PatSnap MCP
Protocol design and endpoint interpretation
NCT07020715 is a Phase 2, not yet recruiting study with not reported planned participants. Allocation is N/A, masking is None (Open Label), and the intervention model is Single Group Assignment.
The primary endpoint is “Efficacy (Change in EDSS score)” over “62 weeks.” The retrieved endpoint description is: To evaluate the efficacy of tolDC administration, the change in Expanded Disability Severity Scale (EDSS) will be employed. The participants' disability level well be checked during every visit. The EDSS consists of a 10-point scale of disease severity ranging from 0, i.e. no disability, to 10, i.e. death from MS. The impact on disability progression will be analyzed by the proportion of participants free from confirmed disability progression, defined by sustained changes in the EDSS score. Disease progression criteria: * 1.0 point in participants with a screening EDSS of 0-5.0 * 0.5 point in those with a screen….
Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of not reported should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.
No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.
Indexed readouts in the surrounding landscape
100 recent result records were selected as contextual evidence for Multiple Sclerosis, Chronic Progressive. These records do not establish direct evidence for NCT07020715 unless the registration number matches.
Benefit–risk profile comparison between dupilumab and upadacitinib: a structured benefit–risk assessment of the Heads Up trial
Phase 3; n=385; Benefit-risk score = 61.0 point ; Benefit-risk score = 66.0 point Source: https://pubmed-ncbi-nlm-nih-gov.libproxy1.nus.edu.sg/42223292/
Real-world outcomes of deucravacitinib in Chinese plaque psoriasis patients: a 24-week prospective study
Phase 4; n=101; PASI75(24-week) = 77.2 % Source: https://pubmed-ncbi-nlm-nih-gov.libproxy1.nus.edu.sg/41769731/
Sustained on/off-treatment disease control with abrocitinib for moderate-to-severe atopic dermatitis
Phase 3; n=not reported; DLQI = 3.5 Point Source: https://pubmed-ncbi-nlm-nih-gov.libproxy1.nus.edu.sg/42165315/
Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.
Asset and sponsor context
TolDC(University Hospital Antwerp) is indexed as Therapeutic vaccine with target not reported biology and a global stage of Phase 2. The asset profile lists UZA as an originator or developer.
UZA is indexed in an unreported country with the website https://www.uza.be. UZA provides clinical , patient care, academic training, and scientific research services. The record lists 1 development-stage drug assets.
For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.
Development white space
- Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
- Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
- Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
- Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
- Sequencing white space. Clarify whether TolDC(University Hospital Antwerp) is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.
White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.
Strategic implications and next readouts
For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.
For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.
Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.
Source trail and bottom line
Anchor trial: NCT07020715
Protocol source: https://clinicaltrials.gov/study/NCT07020715
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 15 October 2026.
TolDC(University Hospital Antwerp) in Multiple Sclerosis, Chronic Progressive is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Efficacy (Change in EDSS score) and 2029-09-30 the leading decision points.
Build and refresh clinical landscape reports with PatSnap MCP
