NCT07451652 Gemcitabine Hydrochloride Diffuse large B-cell lymphoma recurrent Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook
Turn a newly registered trial into a decision-ready clinical landscape. This report examines NCT07451652 using PatSnap Clinical Trials MCP for protocol design and endpoint evidence, with Drug & Asset MCP and Company & Deal Intelligence MCP used as the companion asset and sponsor enrichment workflow. Explore PatSnap MCP Servers to reproduce the research sequence inside an AI workflow.
MCP evidence snapshot: 27 August 2026. Trial records, recruitment status and projected dates can change after the snapshot and should be rechecked before operational decisions.
Why NCT07451652 is a hot trial to watch
Diffuse large B-cell lymphoma recurrent is being segmented by mechanism, treatment setting, geography and endpoint architecture. NCT07451652 is notable because it evaluates Gemcitabine Hydrochloride in a Phase 2 design sponsored by Hospital Universitario. Dr. José Eleuterio González. The main development question is whether the protocol can translate its rationale into a clinically interpretable and operationally credible readout.
Trial landscape snapshot
| Field | Indexed detail |
|---|---|
| Registration | NCT07451652 |
| Official title | Low Dose Epcoritamab Plus GemOx in R/R DLBCL |
| Phase / status | Phase 2 / Recruiting |
| Intervention | Gemcitabine Hydrochloride |
| Sponsor | Hospital Universitario. Dr. José Eleuterio González |
| Geography | Mexico |
| Enrollment | 10 |
| Primary endpoint | Determine ORR and CR after GemOx plus low-dose Epcoritamab |
| Endpoint time frame | From enrollment to the end of treatment at 14 weeks |
| Primary completion / readout proxy | 2027-09-01 |
Protocol design and endpoint interpretation
In this study, researchers are looking to determine whether Gemcitabine/Oxaliplatin plus a lower dose of Epcoritamab (12 mg) works to treat subjects with relapsed/refractory diffuse large B-cell lymphoma, who are candidates to autologous stem cell transplantation.
Allocation is N/A, masking is None (Open Label), and the intervention model is Single Group Assignment. Planned enrollment of 10 participants across Mexico shapes statistical precision, execution risk and external validity. Interpretation should account for baseline risk, prior therapy, assessment schedule, missing-data handling and clinical relevance—not only statistical significance.
- Determine ORR and CR after GemOx plus low-dose Epcoritamab (From enrollment to the end of treatment at 14 weeks) — Determine ORR and CR after 3 cycles of GemOx plus low-dose Epcoritamab based on PET-CT
Readout outlook and evidence gap
The current protocol points to 2027-09-01 as the best available readout proxy. Because this is an active or newly posted study, a trial-specific result citation is not included until a normalized clinical-trial-result record becomes available. That gap is itself operationally important: teams should monitor first result indexing, conference abstracts, protocol amendments and changes to the primary-completion date.
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Asset and sponsor context
Drug & Asset MCP profile: Gemcitabine Hydrochloride is indexed as No normalized modality returned, with target No normalized target returned, mechanism No normalized mechanism returned, and global highest development status No normalized global status returned.
Company & Deal Intelligence MCP profile: Hospital Universitario. Dr. José Eleuterio González is resolved to a normalized organization record in Mexico. The organization workflow adds identity, location, portfolio and partnering context where available.
The sponsor profile matters because scientific rationale alone does not determine development value. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can determine whether a positive signal becomes a competitive asset.
White space around this program
- Sharper patient selection: prospective biomarker or phenotype definitions that identify who is most likely to benefit.
- Clinically interpretable endpoints: outcomes connecting activity with function, symptoms, survival or treatment burden.
- Comparator relevance: evidence against the most decision-relevant contemporary standard of care.
- Broader external validity: evidence across additional geographies, demographic groups and real-world settings.
- Operational differentiation: a development path that closes the readout gap without sacrificing safety or durability.
What to monitor next
Monitor recruitment, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. A change in endpoint, population or ownership can alter the probability of success before a headline data release.
Bottom line
NCT07451652 provides a focused lens on Diffuse large B-cell lymphoma recurrent development. Its value will be determined by whether Gemcitabine Hydrochloride can convert the current Phase 2 design into evidence that is clinically meaningful, operationally credible and differentiated from competing programs.
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