NCT07517419 Doxorubicin Hydrochloride Neoplasm Metastasis Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook
Turn a newly registered trial into a decision-ready clinical landscape. This report examines NCT07517419 using PatSnap Clinical Trials MCP for protocol design and endpoint evidence, with Drug & Asset MCP and Company & Deal Intelligence MCP used as the companion asset and sponsor enrichment workflow. Explore PatSnap MCP Servers to reproduce the research sequence inside an AI workflow.
MCP evidence snapshot: 24 August 2026. Trial records, recruitment status and projected dates can change after the snapshot and should be rechecked before operational decisions.
Why NCT07517419 is a hot trial to watch
Neoplasm Metastasis is being segmented by mechanism, treatment setting, geography and endpoint architecture. NCT07517419 is notable because it evaluates Doxorubicin Hydrochloride in a Phase 2 design sponsored by The Chinese University of Hong Kong. The main development question is whether the protocol can translate its rationale into a clinically interpretable and operationally credible readout.
Trial landscape snapshot
| Field | Indexed detail |
|---|---|
| Registration | NCT07517419 |
| Official title | PIPAC in Gastric Peritoneal Metastasis |
| Phase / status | Phase 2 / Enrolling by invitation |
| Intervention | Doxorubicin Hydrochloride |
| Sponsor | The Chinese University of Hong Kong |
| Geography | Hong Kong |
| Enrollment | [object Object] |
| Primary endpoint | Mortality |
| Endpoint time frame | From recruitment up to five years / death |
| Primary completion / readout proxy | [object Object] |
Protocol design and endpoint interpretation
This is a pilot study aiming at evaluating the effects of PIPAC with Doxorubicin + Cisplastin on patients with PM of gastric cancer. All patients who are diagnosed with gastric cancer with peritoneal metastases in the Prince of Wales Hospital (PWH), HK will be screened for eligibility. There are two aims for this study: 1. To evaluate safety and efficacy of the procedure together with postoperative outcomes and long term overall and progression free survival. 2. Aim at obtaining tissue samples for molecular analysis and for potential tissue organoids and biobank.
Allocation is N/A, masking is None (Open Label), and the intervention model is Single Group Assignment. Planned enrollment of [object Object] participants across Hong Kong shapes statistical precision, execution risk and external validity. Interpretation should account for baseline risk, prior therapy, assessment schedule, missing-data handling and clinical relevance—not only statistical significance.
- Mortality (From recruitment up to five years / death) — We aim to recruit 30 patients or until 5 years has been reached. The patients will then be followed-up to up to 5 years or death. A first report regarding the safety and feasibility would be generated after 15 patients complete the 6-month follow-up.
Readout outlook and evidence gap
The current protocol points to [object Object] as the best available readout proxy. Because this is an active or newly posted study, a trial-specific result citation is not included until a normalized clinical-trial-result record becomes available. That gap is itself operationally important: teams should monitor first result indexing, conference abstracts, protocol amendments and changes to the primary-completion date.
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Asset and sponsor context
Drug & Asset MCP profile: Doxorubicin Hydrochloride is indexed as No normalized modality returned, with target No normalized target returned, mechanism No normalized mechanism returned, and global highest development status No normalized global status returned.
Company & Deal Intelligence MCP profile: The Chinese University of Hong Kong is resolved to a normalized organization record in Hong Kong SAR, China. The organization workflow adds identity, location, portfolio and partnering context where available.
The sponsor profile matters because scientific rationale alone does not determine development value. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can determine whether a positive signal becomes a competitive asset.
White space around this program
- Sharper patient selection: prospective biomarker or phenotype definitions that identify who is most likely to benefit.
- Clinically interpretable endpoints: outcomes connecting activity with function, symptoms, survival or treatment burden.
- Comparator relevance: evidence against the most decision-relevant contemporary standard of care.
- Broader external validity: evidence across additional geographies, demographic groups and real-world settings.
- Operational differentiation: a development path that closes the readout gap without sacrificing safety or durability.
What to monitor next
Monitor recruitment, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. A change in endpoint, population or ownership can alter the probability of success before a headline data release.
Bottom line
NCT07517419 provides a focused lens on Neoplasm Metastasis development. Its value will be determined by whether Doxorubicin Hydrochloride can convert the current Phase 2 design into evidence that is clinically meaningful, operationally credible and differentiated from competing programs.
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