NCT07579429 Nicotinamide riboside CCUS Clonal Cytopenia of Undetermined Significance Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook
Turn a newly registered trial into a decision-ready clinical landscape. This report examines NCT07579429 using PatSnap Clinical Trials MCP for protocol design and endpoint evidence, with Drug & Asset MCP and Company & Deal Intelligence MCP used as the companion asset and sponsor enrichment workflow. Explore PatSnap MCP Servers to reproduce the research sequence inside an AI workflow.
MCP evidence snapshot: 24 July 2026. Trial records, recruitment status and projected dates can change after the snapshot and should be rechecked before operational decisions.
Why NCT07579429 is a hot trial to watch
CCUS Clonal Cytopenia of Undetermined Significance is being segmented by mechanism, treatment setting, geography and endpoint architecture. NCT07579429 is notable because it evaluates Nicotinamide riboside in a Phase 2 design sponsored by University of Colorado Denver. The main development question is whether the protocol can translate its rationale into a clinically interpretable and operationally credible readout.
Trial landscape snapshot
| Field | Indexed detail |
|---|---|
| Registration | NCT07579429 |
| Official title | Research On Nicotinamide Riboside Supplement Support in MDS (ROSS Trial) (ROSS) |
| Phase / status | Phase 2 / Recruiting |
| Intervention | Nicotinamide riboside |
| Sponsor | University of Colorado Denver |
| Geography | United States |
| Enrollment | [object Object] |
| Primary endpoint | Preliminary Efficacy: Cytopenia Improvement |
| Endpoint time frame | 24 weeks |
| Primary completion / readout proxy | [object Object] |
Protocol design and endpoint interpretation
This is an open-label, phase 2 study for lower risk MDS and high risk CCUS patients who are transfusion independent. There will be two cohorts enrolled at the same time to measure the effect of nicotinamide riboside and pterostilbene at different doses. The primary goals of the study are: * to assess if study drug improves cytopenias in patients * to determine safety of the study drug in patients
Allocation is Non-Randomized, masking is None (Open Label), and the intervention model is Parallel Assignment. Planned enrollment of [object Object] participants across United States shapes statistical precision, execution risk and external validity. Interpretation should account for baseline risk, prior therapy, assessment schedule, missing-data handling and clinical relevance—not only statistical significance.
- Preliminary Efficacy: Cytopenia Improvement (24 weeks) — To assess efficacy of nicotinamide riboside and pterostilbene supplementation by assessing whether it increased hemoglobin by 1g/dL in 24 weeks.
Readout outlook and evidence gap
The current protocol points to [object Object] as the best available readout proxy. Because this is an active or newly posted study, a trial-specific result citation is not included until a normalized clinical-trial-result record becomes available. That gap is itself operationally important: teams should monitor first result indexing, conference abstracts, protocol amendments and changes to the primary-completion date.
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Asset and sponsor context
Drug & Asset MCP profile: Nicotinamide riboside is indexed as Small molecule drug, with target NAD+, mechanism NAD+ modulators, and global highest development status Phase 2.
Company & Deal Intelligence MCP profile: University of Colorado Denver is resolved to a normalized organization record in DENVER COUNTY, United States. The organization workflow adds identity, location, portfolio and partnering context where available.
The sponsor profile matters because scientific rationale alone does not determine development value. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can determine whether a positive signal becomes a competitive asset.
White space around this program
- Sharper patient selection: prospective biomarker or phenotype definitions that identify who is most likely to benefit.
- Clinically interpretable endpoints: outcomes connecting activity with function, symptoms, survival or treatment burden.
- Comparator relevance: evidence against the most decision-relevant contemporary standard of care.
- Broader external validity: evidence across additional geographies, demographic groups and real-world settings.
- Operational differentiation: a development path that closes the readout gap without sacrificing safety or durability.
What to monitor next
Monitor recruitment, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. A change in endpoint, population or ownership can alter the probability of success before a headline data release.
Bottom line
NCT07579429 provides a focused lens on CCUS Clonal Cytopenia of Undetermined Significance development. Its value will be determined by whether Nicotinamide riboside can convert the current Phase 2 design into evidence that is clinically meaningful, operationally credible and differentiated from competing programs.
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