NCT07661602 Folic Acid Anemia Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook

Turn a newly registered trial into a decision-ready landscape. This focused report examines NCT07661602—How Precision Diets, Through Gut Bacteria, Affect Anemia in Nepalese Adolescent—using PatSnap Clinical Trials MCP for protocol design and endpoint evidence, Drug & Asset MCP for mechanism and development context, and Company & Deal Intelligence MCP for sponsor background. Explore PatSnap MCP Servers to reproduce the workflow inside an AI research process.

MCP evidence snapshot: 20 July 2026; publication date: 20 July 2026. Trial records can change after the snapshot and should be rechecked before operational decisions.

Why NCT07661602 is a hot trial to watch

Anemia is increasingly segmented by mechanism, biomarker, treatment setting, geography and endpoint architecture. NCT07661602 is notable because it evaluates Folic Acid in a Phase 3 design while The main measure of whether the intervention successfully treats anemia. Hemoglobin will be measured using the cyanmethemoglobin method at baseline and after the 12-week intervention period. The study is powered to detect a minimum clinically important difference of 1.2 g/dL, representing a shift from moderate to mild anemia classification per WHO criteria. serves as the main decision variable. The critical question is whether the protocol can convert its rationale into a clinically interpretable and operationally credible readout.

PatSnap Clinical Trials MCP makes protocol fields machine-readable, while the companion asset and organization servers add development-status, target and sponsor context.

Trial landscape snapshot

Design and endpoint interpretation

The phase label is only the starting point. Allocation is Randomized, masking is Single, and the intervention model is Parallel Assignment. Planned enrollment of 60 participants across Nepal shapes statistical precision, execution risk and external validity. Interpretation should account for baseline risk, prior therapy, assessment schedule, missing-data handling and clinical relevance—not only statistical significance.

• Primary: The main measure of whether the intervention successfully treats anemia. Hemoglobin will be measured using the cyanmethemoglobin method at baseline and after the 12-week intervention period. The study is powered to detect a minimum clinically important difference of 1.2 g/dL, representing a shift from moderate to mild anemia classification per WHO criteria. (12 weeks)
• Secondary: Measures iron stores in the body. Will be assessed using electrochemiluminescence immunoassay (ECLIA) and adjusted for inflammation status (CRP and AGP) using BRINDA project recommendations to obtain accurate iron deficiency classification (12 weeks)
• Secondary: An additional marker of iron status that reflects tissue iron deficiency, particularly useful when inflammation is present. Measured by ELISA. (12 weeks)
• Secondary: Assesses folate status to identify megaloblastic anemia and evaluate whether goat liver (rich in natural folates) improves folate levels compared to synthetic folic acid tablets. Measured by chemiluminescent immunoassay. Deficiency defined as \<3 ng/mL (\<6.8 nmol/L) per WHO guidelines. (12 weeks)
• Secondary: Exploratory/secondary outcome. 16S rRNA gene sequencing of the V4 hypervariable region will assess: alpha diversity (Shannon index, observed ASVs, Faith's phylogenetic diversity); beta diversity (Bray-Curtis and weighted UniFrac distances); and differential abundance of specific taxa (using DESeq2). Stool samples collected using OMNIgene-GUT tubes. (12 weeks)

Benchmark readouts in the surrounding field

• A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of RDX-002 on Postprandial Triglycerides in Patients Discontinuing the Glucagon-like Peptide-1 (GLP-1) Agonists, Semaglutide, or Tirzepatide for the Treatment of Obesity (Phase 2): Incremental Postprandial Triglycerides (TG)(Mean) = 43.81 percent change (Standard Deviation, 92.373); Incremental Postprandial Triglycerides (TG)(Mean) = -51.91 percent change (Standard Deviation, 72.293)
• A Phase II Study to Evaluate the Delay in Ovulation Following Oral Levonorgestrel Plus Meloxicam Compared to Placebo in Obese But Normal Menstruating Women (Phase 2): Interval From First Dose to Evidence of Ovulation.(Mean) = 2.67 Number of days (Standard Deviation, 1.53); Interval From First Dose to Evidence of Ovulation.(Mean) = 4.0 Number of days (Standard Deviation, 0)
• A Phase 2, Parallel-Group, Double-Blind Study to Investigate Weight Management With LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight (Phase 2): Percent Change From Baseline in Body Weight at Week 48(Least Squares Mean) = -0.4 percent change (Standard Error, 0.91); Percent Change From Baseline in Body Weight at Week 48(Least Squares Mean) = -9.4 percent change (Standard Error, 1.60)

These indexed results are contextual benchmarks, not direct head-to-head evidence. Population, treatment line, endpoint definitions, follow-up and analysis sets may differ. Their value is to clarify the type and magnitude of evidence already visible in the competitive landscape.

Build a living trial monitor: connect to PatSnap MCP Servers and track status changes, endpoint revisions, primary-completion dates and newly indexed results without manually reconciling separate databases.

Asset and sponsor context

Drug & Asset context: Folic Acid (Approved; Folate receptor)

Company & Deal Intelligence context: Southern Medical University — China — https://www.smu.edu.cn

The sponsor profile matters because scientific rationale alone does not determine development value. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can decide whether a positive signal becomes a competitive asset.

White space around this program

• Sharper patient selection: prospective biomarker or phenotype definitions that identify who is most likely to benefit.
• Clinically interpretable endpoints: outcomes connecting activity with function, symptoms, survival or treatment burden.
• Sequencing evidence: comparative data after the most relevant contemporary standard of care.
• Broader external validity: evidence across additional geographies, demographic groups and real-world settings.
• Operational differentiation: a development path that closes the readout gap without sacrificing safety or durability.

What to monitor next

Monitor recruitment, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. A change in endpoint, population or ownership can alter probability of success before a headline data release.

Bottom line

NCT07661602 is a focused lens on Anemia development. Its value will be determined by whether Folic Acid can convert the current design into evidence that is clinically meaningful, operationally credible and differentiated from indexed benchmark readouts.

Ready to reproduce this analysis? Explore PatSnap MCP Servers and combine Clinical Trials, Drug & Asset, and Company & Deal Intelligence as reusable building blocks for trial monitoring and SEO-ready clinical reports.