NCT07672860 Ursodiol Kidney Neoplasms Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook

Turn a newly registered trial into a decision-ready landscape. This focused report examines NCT07672860—Perioperative Ursodeoxycholic Acid for Renal Protection in Adults Undergoing Partial Nephrectomy for Renal Tumors (PURIFY)—using PatSnap Clinical Trials MCP for protocol design and endpoint evidence, Drug & Asset MCP for mechanism and development context, and Company & Deal Intelligence MCP for sponsor background. Explore PatSnap MCP Servers to reproduce the workflow inside an AI research process.

MCP evidence snapshot: 20 July 2026; publication date: 20 July 2026. Trial records can change after the snapshot and should be rechecked before operational decisions.

Why NCT07672860 is a hot trial to watch

Kidney Neoplasms is increasingly segmented by mechanism, biomarker, treatment setting, geography and endpoint architecture. NCT07672860 is notable because it evaluates Ursodiol in a Phase 2 design while Defined according to the serum creatinine criterion of the KDIGO criteria serves as the main decision variable. The critical question is whether the protocol can convert its rationale into a clinically interpretable and operationally credible readout.

PatSnap Clinical Trials MCP makes protocol fields machine-readable, while the companion asset and organization servers add development-status, target and sponsor context.

Trial landscape snapshot

Design and endpoint interpretation

The phase label is only the starting point. Allocation is Randomized, masking is Quadruple, and the intervention model is Parallel Assignment. Planned enrollment of 146 participants across China shapes statistical precision, execution risk and external validity. Interpretation should account for baseline risk, prior therapy, assessment schedule, missing-data handling and clinical relevance—not only statistical significance.

• Primary: Defined according to the serum creatinine criterion of the KDIGO criteria (From baseline to 48 hours after surgery.)
• Secondary: Defined according to either the serum creatinine or urine output criterion of the KDIGO criteria (From baseline to 48 hours after surgery.)
• Secondary: This endpoint will be assessed using an analysis of covariance model (From baseline to 24 hours after surgery.)
• Secondary: This endpoint will be assessed using an analysis of covariance model (From baseline to 48 hours after surgery.)
• Secondary: Maximum absolute increase = highest postoperative serum creatinine within 48 hours - baseline serum creatinine (From baseline to 48 hours after surgery.)

Benchmark readouts in the surrounding field

• A Randomized, Dose-ranging, Open-label, Parallel Group Study to Assess the Efficacy, Safety and Pharmacokinetics of Palonosetron HCl Buccal Film Versus IV Palonosetron 0.25 mg for the Prevention of CINV in Cancer Patients Receiving MEC (Phase 2): Complete Acute Response = 4 Participants ; Complete Acute Response = 3 Participants
• Fixed-Dose Netupitant and Palonosetron for Chronic Nausea and Vomiting in Cancer Patients (Phase 2/3): Change in Nausea Numerical Rating Scale (NRS) Between Day 5 and Day 15(Mean): P-Value = 0.98; Change in Nausea Numerical Rating Scale (NRS) Between Day 5 and Day 15(Mean): P-Value = 0.98
• A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of RDX-002 on Postprandial Triglycerides in Patients Discontinuing the Glucagon-like Peptide-1 (GLP-1) Agonists, Semaglutide, or Tirzepatide for the Treatment of Obesity (Phase 2): Incremental Postprandial Triglycerides (TG)(Mean) = 43.81 percent change (Standard Deviation, 92.373); Incremental Postprandial Triglycerides (TG)(Mean) = -51.91 percent change (Standard Deviation, 72.293)

These indexed results are contextual benchmarks, not direct head-to-head evidence. Population, treatment line, endpoint definitions, follow-up and analysis sets may differ. Their value is to clarify the type and magnitude of evidence already visible in the competitive landscape.

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Asset and sponsor context

Drug & Asset context: Ursodiol (Approved; FXR)

Company & Deal Intelligence context: Not reported

The sponsor profile matters because scientific rationale alone does not determine development value. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can decide whether a positive signal becomes a competitive asset.

White space around this program

• Sharper patient selection: prospective biomarker or phenotype definitions that identify who is most likely to benefit.
• Clinically interpretable endpoints: outcomes connecting activity with function, symptoms, survival or treatment burden.
• Sequencing evidence: comparative data after the most relevant contemporary standard of care.
• Broader external validity: evidence across additional geographies, demographic groups and real-world settings.
• Operational differentiation: a development path that closes the readout gap without sacrificing safety or durability.

What to monitor next

Monitor recruitment, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. A change in endpoint, population or ownership can alter probability of success before a headline data release.

Bottom line

NCT07672860 is a focused lens on Kidney Neoplasms development. Its value will be determined by whether Ursodiol can convert the current design into evidence that is clinically meaningful, operationally credible and differentiated from indexed benchmark readouts.

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