NCT07684235 Maridebart Cafraglutide Obesity Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook
Turn a newly registered trial into a decision-ready clinical landscape. This report examines NCT07684235 using PatSnap Clinical Trials MCP for protocol design and endpoint evidence, with Drug & Asset MCP and Company & Deal Intelligence MCP used as the companion asset and sponsor enrichment workflow. Explore PatSnap MCP Servers to reproduce the research sequence inside an AI workflow.
MCP evidence snapshot: 21 July 2026. Trial records, recruitment status and projected dates can change after the snapshot and should be rechecked before operational decisions.
Why NCT07684235 is a hot trial to watch
Obesity is being segmented by mechanism, treatment setting, geography and endpoint architecture. NCT07684235 is notable because it evaluates Maridebart Cafraglutide in a Phase 3 design sponsored by Amgen, Inc.. The main development question is whether the protocol can translate its rationale into a clinically interpretable and operationally credible readout.
Trial landscape snapshot
| Field | Indexed detail |
|---|---|
| Registration | NCT07684235 |
| Official title | Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION) |
| Phase / status | Phase 3 / Not yet recruiting |
| Intervention | Maridebart Cafraglutide |
| Sponsor | Amgen, Inc. |
| Geography | Not reported in the indexed record |
| Enrollment | 3200 |
| Primary endpoint | Percent Change in Body Weight from Baseline of the Parent Trial (20210181) |
| Endpoint time frame | Baseline of parent trial (20210181) to Week 48 of current trial |
| Primary completion / readout proxy | 2027-12-26 |
Protocol design and endpoint interpretation
The primary objective of this trial is to evaluate the long-term efficacy, safety, and tolerability of maridebart cafraglutide in participants with obesity or overweight. Trial 20250197 is an extension of trial 20210181 (NCT06858839).
Allocation is Randomized, masking is Double, and the intervention model is Parallel Assignment. Planned enrollment of 3200 participants across Not reported in the indexed record shapes statistical precision, execution risk and external validity. Interpretation should account for baseline risk, prior therapy, assessment schedule, missing-data handling and clinical relevance—not only statistical significance.
- Percent Change in Body Weight from Baseline of the Parent Trial (20210181) (Baseline of parent trial (20210181) to Week 48 of current trial)
- Number of Participants Experiencing Treatment-emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs) (Baseline of current trial up to 60 weeks)
Readout outlook and evidence gap
The current protocol points to 2027-12-26 as the best available readout proxy. Because this is an active or newly posted study, a trial-specific result citation is not included until a normalized clinical-trial-result record becomes available. That gap is itself operationally important: teams should monitor first result indexing, conference abstracts, protocol amendments and changes to the primary-completion date.
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Asset and sponsor context
Trial-sourced asset: Maridebart Cafraglutide. The Drug & Asset MCP enrichment step is designed to add normalized targets, modality and global development status when an exact asset match is available.
Trial-sourced sponsor: Amgen, Inc.. Company & Deal Intelligence MCP is the companion workflow for resolving organization identity, corporate profile and partnering context.
The sponsor profile matters because scientific rationale alone does not determine development value. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can determine whether a positive signal becomes a competitive asset.
White space around this program
- Sharper patient selection: prospective biomarker or phenotype definitions that identify who is most likely to benefit.
- Clinically interpretable endpoints: outcomes connecting activity with function, symptoms, survival or treatment burden.
- Comparator relevance: evidence against the most decision-relevant contemporary standard of care.
- Broader external validity: evidence across additional geographies, demographic groups and real-world settings.
- Operational differentiation: a development path that closes the readout gap without sacrificing safety or durability.
What to monitor next
Monitor recruitment, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. A change in endpoint, population or ownership can alter the probability of success before a headline data release.
Bottom line
NCT07684235 provides a focused lens on Obesity development. Its value will be determined by whether Maridebart Cafraglutide can convert the current Phase 3 design into evidence that is clinically meaningful, operationally credible and differentiated from competing programs.
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