NCT07696871 Cannabidiol Major Depressive Disorder Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook

Move from a broad disease map to a decision-ready trial dossier. This focused report examines NCT07696871—Cannabidiol Oil for Treatment-Resistant Major Depression (ANANDA)—using PatSnap Clinical Trials, Drug & Asset, and Company & Deal Intelligence MCP evidence. Explore PatSnap MCP Servers to reproduce the workflow inside an AI research process.

MCP evidence snapshot: 16 July 2026; publication date: 17 July 2026. Trial records can change after the snapshot and should be rechecked before operational decisions.

Why NCT07696871 is a hot trial to watch

Major Depressive Disorder is no longer one homogeneous development market. The most consequential programs increasingly compete through a specific mechanism, biomarker, treatment line, delivery strategy or endpoint architecture. NCT07696871 is notable because it tests Cannabidiol in a Phase 1/2 design with Change in Depressive Symptom Severity Assessed by the Hamilton Depression Rating Scale (HAM-17) as a primary decision variable. The wider PatSnap topic query returned 1,478 trial records and 796 result records, so differentiation depends on evidence quality rather than activity alone.

PatSnap Clinical Trials MCP makes the protocol fields machine-readable, while the companion asset and organization servers add mechanism and sponsor context.

Trial landscape snapshot

Design and endpoint interpretation

The design should be read as an evidence architecture, not just a phase label. The primary endpoint—Change in Depressive Symptom Severity Assessed by the Hamilton Depression Rating Scale (HAM-17)—determines what uncertainty this study can resolve. The reported time frame is Baseline, Week 4, and Week 12. Enrollment of 120 participants and geography in Brazil shape statistical precision, operational risk and external validity. A strong readout will need to be interpreted against baseline risk, prior treatment, assessment schedule, missing-data handling and the clinical relevance of the observed effect.

Benchmark readouts in the same clinical field

• A Phase 3, Multicenter, Randomized, Double-Blind, Placebo- Controlled Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment of Major Depressive Disorder (The RELIANCE-II Study) (Phase 3): Change From Baseline to Day 28 in MADRS Total Score(Least Squares Mean) = -13.9 Scores on a scale (MADRS10) (Standard Error, 1.01); Change From Baseline to Day 28 in MADRS Total Score(Least Squares Mean) = -14.81 Scores on a scale (MADRS10) (Standard Error, 1.00); -; -; -.
• A Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as an Adjunctive Treatment for Major Depressive Disorder (RELIGHT) (Phase 3): Change From Baseline to Day 28 in Montgomery-Åsberg Depression Rating Scale (MADRS) Total Score(Mean) = -13.4 Scores on a scale (MADRS10) (Standard Deviation, 9.55); Change From Baseline to Day 28 in Montgomery-Åsberg Depression Rating Scale (MADRS) Total Score(Mean) = -16.8 Scores on a scale (MADRS10) (Standard Deviation, 7.62); -; -; -.
• A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Design, Phase 2 Study to Assess the Efficacy and Safety of CLE-100 as an Adjunctive Treatment for Major Depressive Disorder Patients With Inadequate Response to Standard Antidepressants (Phase 2): Change From Baseline in Montgomery-Asberg Depression Rating Scale (MADRS) Score(Least Squares Mean) = -8.70 units on a scale (Standard Error, 1.55); Change From Baseline in Montgomery-Asberg Depression Rating Scale (MADRS) Score(Least Squares Mean) = -11.66 units on a scale (Standard Error, 1.50); Change From Baseline in Montgomery-Asberg Depression Rating Scale (MADRS) Score(Least Squares Mean): Least square (LS) mean difference = -2.96(95% CI, -7.01 to 1.09), P-Value = 0.15; Change From Baseline in Montgomery-Asberg Depression Rating Scale (MADRS) Score(Least Squares Mean): Least square (LS) mean difference = -2.96(95% CI, -7.01 to 1.09), P-Value = 0.15; Change From Baseline in Montgomery-Asberg Depression Rating Scale (MADRS) Score(Least Squares Mean): Least square (LS) mean difference = -2.96(95% CI, -7.01 to 1.09), P-Value = 0.15.

These result records are contextual benchmarks rather than direct head-to-head evidence. Cross-trial comparisons can be distorted by population, line of therapy, endpoint definition, follow-up and analysis set. Their value is to clarify what magnitude and type of evidence the market already recognizes.

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Asset and sponsor context

Drug & Asset context: Cannabidiol (Approved; target not reported).

Company & Deal Intelligence context: Universidade Do Sul De Santa Catarina — https://www.unisul.br.

The sponsor profile matters because a trial's strategic value depends on more than scientific rationale. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can determine whether a positive signal becomes a competitive asset.

White space around this program

1. Sharper patient selection: prospective biomarker definitions that identify who is most likely to benefit.
2. Clinically interpretable endpoints: outcomes that connect biological activity with function, symptoms, survival or treatment burden.
3. Sequencing evidence: randomized data after the most relevant contemporary standard of care.
4. Broader external validity: evidence across additional geographies, demographic groups and real-world care settings.
5. Operational differentiation: a development path that closes the readout gap without sacrificing safety monitoring or durability.

What to monitor next

Monitor recruitment status, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. The most important inflection point is not always the headline data release; a change in endpoint, population or ownership can alter probability of success months earlier.

Bottom line

NCT07696871 is a focused lens on Major Depressive Disorder development. Its value will be determined by whether Cannabidiol can convert the current design into evidence that is clinically meaningful, operationally credible and differentiated from topic-level benchmark readouts.

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