NCT07716618 SAL0120 Chronic Kidney Diseases Clinical Landscape Report 2026: Design, Endpoints, Sponsor and Readout Outlook
Turn a newly registered trial into a decision-ready clinical landscape. This report examines NCT07716618 using PatSnap Clinical Trials MCP for protocol design and endpoint evidence, with Drug & Asset MCP and Company & Deal Intelligence MCP used as the companion asset and sponsor enrichment workflow. Explore PatSnap MCP Servers to reproduce the research sequence inside an AI workflow.
MCP evidence snapshot: 3 August 2026. Trial records, recruitment status and projected dates can change after the snapshot and should be rechecked before operational decisions.
Why NCT07716618 is a hot trial to watch
Chronic Kidney Diseases is being segmented by mechanism, treatment setting, geography and endpoint architecture. NCT07716618 is notable because it evaluates SAL0120 in a Phase 2 design sponsored by Shenzhen Salubris Pharmaceuticals Co., Ltd.. The main development question is whether the protocol can translate its rationale into a clinically interpretable and operationally credible readout.
Trial landscape snapshot
| Field | Indexed detail |
|---|---|
| Registration | NCT07716618 |
| Official title | A Phase II Clinical Trial of the Safety and Efficacy of SAL0120 in Patients With Chronic Kidney Disease (CKD) |
| Phase / status | Phase 2 / Active, not recruiting |
| Intervention | SAL0120 |
| Sponsor | Shenzhen Salubris Pharmaceuticals Co., Ltd. |
| Geography | China |
| Enrollment | [object Object] |
| Primary endpoint | The baseline relative change in UACR；The change from baseline in UACR across SAL0120 dose groups |
| Endpoint time frame | at 12 weeks |
| Primary completion / readout proxy | [object Object] |
Protocol design and endpoint interpretation
This study is a multicenter, randomized, double-blind, placebo-controlled, parallel-design clinical trial designed to investigate the efficacy and safety of different doses of sal0120 tablets in patients with CKD.
Allocation is Randomized, masking is Quadruple, and the intervention model is Parallel Assignment. Planned enrollment of [object Object] participants across China shapes statistical precision, execution risk and external validity. Interpretation should account for baseline risk, prior therapy, assessment schedule, missing-data handling and clinical relevance—not only statistical significance.
- The baseline relative change in UACR；The change from baseline in UACR across SAL0120 dose groups (at 12 weeks) — At 12 weeks of treatment, the changes in UACR (urinary albumin/creatinine ratio) relative to baseline were compared in each group; the differences in the changes in UACR relative to baseline among different dose groups of SAL0120 tablets were assessed.
Readout outlook and evidence gap
The current protocol points to [object Object] as the best available readout proxy. Because this is an active or newly posted study, a trial-specific result citation is not included until a normalized clinical-trial-result record becomes available. That gap is itself operationally important: teams should monitor first result indexing, conference abstracts, protocol amendments and changes to the primary-completion date.
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Asset and sponsor context
Drug & Asset MCP profile: SAL0120 is indexed as Small molecule drug, with target ETA, mechanism ETA antagonists, and global highest development status Phase 2.
Company & Deal Intelligence MCP profile: Shenzhen Salubris Pharmaceuticals Co., Ltd. is resolved to a normalized organization record in Shenzhen, China. The organization workflow adds identity, location, portfolio and partnering context where available.
The sponsor profile matters because scientific rationale alone does not determine development value. Manufacturing readiness, portfolio fit, geographic reach, partnering capacity and the ability to fund confirmatory development can determine whether a positive signal becomes a competitive asset.
White space around this program
- Sharper patient selection: prospective biomarker or phenotype definitions that identify who is most likely to benefit.
- Clinically interpretable endpoints: outcomes connecting activity with function, symptoms, survival or treatment burden.
- Comparator relevance: evidence against the most decision-relevant contemporary standard of care.
- Broader external validity: evidence across additional geographies, demographic groups and real-world settings.
- Operational differentiation: a development path that closes the readout gap without sacrificing safety or durability.
What to monitor next
Monitor recruitment, enrollment changes, protocol amendments, endpoint hierarchy, primary-completion timing, first result indexing, asset ownership and sponsor partnerships. A change in endpoint, population or ownership can alter the probability of success before a headline data release.
Bottom line
NCT07716618 provides a focused lens on Chronic Kidney Diseases development. Its value will be determined by whether SAL0120 can convert the current Phase 2 design into evidence that is clinically meaningful, operationally credible and differentiated from competing programs.
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