Isoquercetin in Ovarian Serous Tumor: NCT07303894 Clinical Landscape Report 2026
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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.
Data snapshot: 15 October 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.
Phase 2
Clinical phase
Recruiting
Recruitment status
not reported
Planned enrollment
2032-01-01
Primary-completion proxy
Executive view
NCT07303894 evaluates Isoquercetin in Ovarian Serous Tumor. The disclosed sponsor is Memorial Sloan Kettering Cancer Center, the design is Interventional, and the geographic footprint is United States. The first listed primary endpoint is Level of PDI-sensitive, platelet-dependent thrombin generation measured as compared to baseline, assessed over up to 6 weeks from baseline.
The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.
PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.
How the MCP evidence stack was assembled
Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07303894 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Ovarian Serous Tumor landscape. Drug & Asset MCP drug_fetch was queried for Isoquercetin, while Company & Deal Intelligence MCP organization_fetch was queried for Memorial Sloan Kettering Cancer Center.
This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Readout proxy |
|---|---|---|---|---|---|---|
| NCT07303894 | Isoquercetin | Phase 2 / Recruiting | Memorial Sloan Kettering Cancer Center | United States | Level of PDI-sensitive, platelet-dependent thrombin generation measured as compared to baseline up to 6 weeks from baseline | 2032-01-01 |
| NCT07460180 | Olaparib | Phase 1/2 / Recruiting | Netherlands Cancer Insitute | Netherlands | Safety and toxicity of combining PARP-inhibitors with HIPEC 4 years | 2027-05-01 |
| ISRCTN15843444 | Doxorubicin Hydrochloride | Not Applicable / No longer recruiting | Sponsor not reported | Russia | Primary endpoint not reported Time frame not reported | 2025-01-15 |
| NCT07455071 | YS-247 | Not Applicable / Not yet recruiting | Peking University Third Hospital | Geography not reported | Evaluate the safety and tolerability of YS247 in study participants with HRD-negative epithelial ovarian cancer, and to… 12 months | 2027-09-30 |
| NCT07435701 | SK-NK | Phase 1/2 / Recruiting | Cancer Hospital Chinese Academy of Medical Sciences | China | Incidence of Adverse Events and Dose-Limiting Toxicities From baseline up to 28 days post-infusion for DLT; safety follow-up t… | 2026-01-23 |
The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.
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Protocol design and endpoint interpretation
NCT07303894 is a Phase 2, recruiting study with not reported planned participants. Allocation is Randomized, masking is Double, and the intervention model is Parallel Assignment.
The primary endpoint is “Level of PDI-sensitive, platelet-dependent thrombin generation measured as compared to baseline” over “up to 6 weeks from baseline.” The retrieved endpoint description is: The primary endpoint is the maximal inhibition of PDI-sensitive, platelet-dependent thrombin generation measured at either 3 or 6 weeks (relative to baseline)..
Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of not reported should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.
No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.
Indexed readouts in the surrounding landscape
0 recent result records were selected as contextual evidence for Ovarian Serous Tumor. These records do not establish direct evidence for NCT07303894 unless the registration number matches.
Indexed evidence status
No directly comparable result record was retrieved for this disease query. This is a monitoring gap, not evidence of absence.
Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.
Asset and sponsor context
Isoquercetin is indexed as Small molecule drug with STAT3 biology and a global stage of Phase 3. The asset profile lists originator not reported as an originator or developer.
Memorial Sloan Kettering Cancer Center is indexed in an unreported country with the website http://www.mskcc.org. Memorial Sloan - Kettering Cancer Center develops health-related apps and educational programs for mobile platforms. The record lists 151 development-stage drug assets.
For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.
Development white space
- Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
- Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
- Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
- Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
- Sequencing white space. Clarify whether Isoquercetin is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.
White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.
Strategic implications and next readouts
For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.
For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.
Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.
Source trail and bottom line
Anchor trial: NCT07303894
Protocol source: https://clinicaltrials.gov/study/NCT07303894
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 15 October 2026.
Isoquercetin in Ovarian Serous Tumor is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Level of PDI-sensitive, platelet-dependent thrombin generation measured as compared to baseline and 2032-01-01 the leading decision points.
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