ES502 NCT07649928 Clinical Landscape 2026

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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.

Data snapshot: 18 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.

Early Phase 1

Clinical phase

Recruiting

Recruitment status

24

Planned enrollment

2028-12-01

Primary-completion proxy

Executive view

NCT07649928 evaluates ES502 in Pancreatic Cancer. The disclosed sponsor is Ruijin Hospital, the design is Interventional, and the geographic footprint is China. The first listed primary endpoint is To evaluate the safety and tolerability of ES502 in subjects with advanced solid tumors, assessed over 2 years.

The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.

PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.

How the MCP evidence stack was assembled

Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07649928 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Pancreatic Cancer landscape. Drug & Asset MCP drug_fetch was queried for ES502, while Company & Deal Intelligence MCP organization_fetch was queried for Ruijin Hospital.

This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.

Trial landscape table

Trial	Asset / intervention	Phase / status	Sponsor	Geography	Primary endpoint	Readout proxy
NCT07649928	ES502	Early Phase 1 / Recruiting	Ruijin Hospital	China	To evaluate the safety and tolerability of ES502 in subjects with advanced solid tumors 2 years	2028-12-01
NCT07699757	Albumin-Bound Paclitaxel	Phase 1 / Not yet recruiting	Haisco Pharmaceutical Group Co., Ltd.	China	DLTs 21 days for NSCLC cohorts; 28 days for PDAC cohorts	2029-04-01
NCT07683221	Ipilimumab	Phase 2 / Not yet recruiting	Shandong First Medical University Affiliated Tumor Hospital (Shandong Cancer Research Institute Shandong Tumor Hospital)	China	Progression-Free Survival (PFS) From initiation of study treatment until disease progression or death…	2029-07-15
NCT07650357	CLSP-5282	Phase 1 / Not yet recruiting	Clasp Therapeutics, Inc.	United States	Part A Monotherapy Dose Escalation 28 days after infusion	2029-05-01
NCT07645651	Samuraciclib hydrochloride	Phase 1 / Recruiting	University of Washington	United States	Change in ribonucleic acid polymerase II serine levels Within 72 hours post versus pre-samuraciclib treatment	2027-07-14

The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.

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Protocol design and endpoint interpretation

NCT07649928 is a Early Phase 1, recruiting study with 24 planned participants. Allocation is N/A, masking is None (Open Label), and the intervention model is Single Group Assignment.

The primary endpoint is “To evaluate the safety and tolerability of ES502 in subjects with advanced solid tumors” over “2 years.” The retrieved endpoint description is: DLT, and incidence and severity of adverse effects..

Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 24 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.

No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.

Indexed readouts in the surrounding landscape

5 recent result records were selected as contextual evidence for Pancreatic Cancer. These records do not establish direct evidence for NCT07649928 unless the registration number matches.

Phase II Trial Evaluating the Safety and Efficacy of Atezolizumab in Combination With Cabozantinib for the Treatment of Metastatic, Refractory Pancreatic Cancer

Phase 2; n=32; ORR = 0.06 Proportion of participants (95% Confidence Interval, 0.00 - 0.27) Source: https://clinicaltrials.gov/ct2/show/results/NCT04820179

A Pilot Study of Pembrolizumab and Liver-Directed Therapy or Peptide Receptor Radionuclide Therapy for Patients With Well-Differentiated Neuroendocrine Tumors and Symptomatic and/…

Phase 2; n=32; Proportion of Participants With an Overall Response = 0.35 proportion of participants (90% Confidence Interval, 0.20 - 0.52); Proportion of Participants With an Overall Response = 0 proportion of participants (90% Confidence Interval, 0 - 0.63) Source: https://clinicaltrials.gov/ct2/show/results/NCT03457948

A Phase 2 Multi-center, Open-label, Single Arm Study of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pan…

Phase 2; n=12; Percentage of Participants With Objective Response Rate = 8.3 Percent of participants (95% Confidence Interval, 0.2 - 38.5) Source: https://clinicaltrials.gov/ct2/show/results/NCT05997056

Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.

Asset and sponsor context

ES502 is indexed as Antibody fusion proteins with KRAS G12V biology and a global stage of IND Approval. The asset profile lists Shanghai Essight Bio Co.,Ltd as an originator or developer.

Ruijin Hospital is indexed in China with the website http://www.rjh.com.cn/chpage/c1352. The organization record is used to resolve sponsor identity. The record lists 37 development-stage drug assets.

For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.

Development white space

Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
Sequencing white space. Clarify whether ES502 is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.

White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.

Strategic implications and next readouts

For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.

For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.

Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.

Source trail and bottom line

Anchor trial: NCT07649928
Protocol source: https://clinicaltrials.gov/study/NCT07649928
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 18 September 2026.

ES502 in Pancreatic Cancer is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes To evaluate the safety and tolerability of ES502 in subjects with advanced solid tumors and 2028-12-01 the leading decision points.

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