Peripheral T-Cell Lymphoma Clinical Landscape Report 2026: Trials, Readouts and White Space
Turn fragmented clinical intelligence into a decision-ready landscape. This report was assembled with PatSnap MCP Servers for Clinical Trials, Drug & Asset, and Company & Deal Intelligence. Explore the PatSnap MCP Marketplace to reproduce the workflow in your own AI research stack.
Data snapshot: 16 July 2026. This report is a strategic research view, not medical advice. Trial status and timing can change; confirm records before making development or investment decisions.
Executive view
Peripheral T-Cell Lymphoma remains an active clinical development field. The competitive center of gravity is moving toward biomarker-defined populations, rational combinations, earlier treatment lines and evidence that can survive active-comparator scrutiny. The PatSnap evidence set used here contains 245 matched trial records and 383 indexed result records before the decision-focused sample below was selected.
How PatSnap MCP built this report
The workflow used Clinical Trials MCP search to define the landscape, then clinical_trial_fetch to retrieve trial design, phase, status, sponsor, geography, endpoints and timing. It separately called clinical_trial_result_fetch for indexed readouts. Drug & Asset drug_fetch supplied target and global development status, while Company & Deal Intelligence organization_fetch supplied sponsor context. This keeps trial-, asset- and company-level claims distinct and traceable.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Expected readout |
|---|---|---|---|---|---|---|
| NCT07691450 | Fludeoxyglucose F-18 + Pralatrexate + Belinostat | Phase 1; Not yet recruiting | City of Hope National Medical Center | United States | Occurrence of dose-limiting toxicities (DLT) (Arm A) (Prior to cycle 2 day 1 (cycle length = 28 days)); Occurrence of DLT (Arm B) (Prior to cycle 2 day 1 (cycle length = 21 days)) | 2029-11-24 |
| NCT07676175 | Cyclophosphamide + Prednisone + Doxorubicin Hydrochloride | Phase 2; Not yet recruiting | BeBetter Med, Inc. | China | Overall Response Rate (ORR) (Up to 24 months) | 2028-01-31 |
| NCT07657572 | Intervention not normalized | Not Applicable; Not yet recruiting | Ruijin Hospital | Geography not listed | Progression-free survival (Baseline up to data cut-off (up to approximately 4 years)) | 2029-12-01 |
| NCT07639879 | TR115 | Phase 3; Not yet recruiting | Tarapeutics Science Inc | China | Progression-Free Survival (PFS) (From randomization to disease progression or death from any cause, whichever…) | 2029-07-30 |
The table is designed for competitive decisions: endpoint selection, geographic reach and readout timing appear beside phase and sponsor. Phase alone does not reveal evidence maturity; a small study may answer a near-term biomarker question while a large pivotal program can leave a multi-year readout gap.
What indexed results say
- A Phase 1/2 Study of the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Relatlimab Plus Nivolumab in Pediatric and Young Adult Participants With Recurrent or Refractory Classical Hodgkin Lymphoma and Non-Hodgkin Lymphoma (Phase 1/2): the indexed record reports Number of Participants With Dose-Limiting Toxicities (DLTs) - Part A = 0 Participants; Number of Participants With Dose-Limiting Toxicities (DLTs) - Part A = 0 Participants; -.
- A Phase 2, Single-Arm, Open-Label, Multicenter Study of Brentuximab Vedotin in Combination With Cyclophosphamide, Doxorubicin (Hydroxydaunorubicin), Prednisone (CHP) in the Frontline Treatment of Chinese Patients With CD30-Positive (CD30+) Peripheral T-Cell Lymphomas (PTCL) (Phase 2): the indexed record reports -; Overall Response Rate (ORR) by Independent Review Facility (IRF) Assessment Per Revised Response Criteria for Malignant Lymphoma = 96.2 percentage of participants (95% Confidence Interval, 86.8 - 99.5); -.
- First-in-human dual-epitope nanobody anti-CD5 CAR-T for relapsed/refractory T-ALL/PTCL: Phase I dose-escalation and expansion results from the CONQUER trial. (Phase 1): the indexed record reports RP2D = 2.0 ×10^6 CAR-T cells/kg.
Cross-trial comparisons require caution. Population, prior therapy, baseline risk, endpoint definition, follow-up and analysis set can all change the apparent signal. The strategic value lies in identifying what each readout resolves—and which uncertainty remains.
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Asset and sponsor context
PatSnap Drug & Asset records add mechanism and global development status for the sampled programs, including Fludeoxyglucose F-18 (Approved), Pralatrexate (Approved; DHFR), Belinostat (Approved; HDACs), Cyclophosphamide (Approved; DNA), Prednisone (Approved; GR). Company & Deal Intelligence records identify sponsor context for City of Hope National Medical Center, BeBetter Med, Inc. (688759), Ruijin Hospital, Tarapeutics Science Inc. Together, those layers show whether a study sits inside a scaled portfolio, an emerging specialist strategy or an academic development path.
Where the white space is
- Prospective biomarker thresholds that predict benefit rather than simply confirm target presence.
- Randomized sequencing evidence after prior targeted therapy, immunotherapy or antibody–drug conjugates.
- Endpoints that connect response depth with durability, quality of life and overall survival.
- Geographically broader development programs with harmonized molecular testing.
Strategic implications
For sponsors, differentiation is more credible when the evidence package resolves a known decision gap: an active comparator, a better-defined responder population, a safer or easier delivery model, a clinically meaningful outcome, or a defensible sequencing strategy. Business-development teams can use the same landscape to separate crowded mechanisms from differentiated evidence architectures. Investors should track endpoint maturity and operational feasibility alongside nominal phase.
What to monitor next
Track status changes, protocol amendments, primary-completion dates, newly indexed results, ownership changes and multinational expansion. Re-run the MCP queries on a schedule and compare deltas. Pay particular attention when a program moves from a surrogate endpoint to a clinical outcome or when a specialist sponsor adds a scaled development partner.
Bottom line
Peripheral T-Cell Lymphoma has meaningful clinical activity and equally meaningful evidence gaps. A useful landscape connects trial design, results, mechanism and sponsor rather than listing studies in isolation.
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