Pentoxifylline NCT07626788 Clinical Landscape 2026

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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.

Data snapshot: 16 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.

Not Applicable

Clinical phase

Not yet recruiting

Recruitment status

140

Planned enrollment

2027-03-01

Primary-completion proxy

Executive view

NCT07626788 evaluates Pentoxifylline in Plaque psoriasis. The disclosed sponsor is University of Phayao, the design is Interventional, and the geographic footprint is Thailand. The first listed primary endpoint is Proportion of Participants Achieving PASI 50, assessed over Week 12.

The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.

PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.

How the MCP evidence stack was assembled

Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07626788 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Plaque psoriasis landscape. Drug & Asset MCP drug_fetch was queried for Pentoxifylline, while Company & Deal Intelligence MCP organization_fetch was queried for University of Phayao.

This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.

Trial landscape table

Trial	Asset / intervention	Phase / status	Sponsor	Geography	Primary endpoint	Readout proxy
NCT07626788	Pentoxifylline	Not Applicable / Not yet recruiting	University of Phayao	Thailand	Proportion of Participants Achieving PASI 50 Week 12	2027-03-01
NCT07746479	Lecankitug	Phase 3 / Completed	Livzon Pharmaceutical Group, Inc.	China	PASI100 response rate At week 12	2026-01-26
NCT07744191	Clopidogrel Bisulfate	Phase 4 / Not yet recruiting	NYU Langone Health	United States	Mean change in the composite endothelial pro-inflammatory transcript expression Baseline, Follow-up Visit 1 (Week 4)	2031-09-01
ACTRN12626000951358	Semaglutide (Novo Nordisk)	Not Applicable / Not yet recruiting	Bayside Health	Australia		Timing not reported
NCT07733089	ZP-9830	Phase 1 / Recruiting	Zealand Pharma A/S	Netherlands	Number of Treatment Emergent Adverse Events (TEAEs) From baseline (Day 1, predose) to follow-up (Day 85)	2027-04-01

The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.

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Protocol design and endpoint interpretation

NCT07626788 is a Not Applicable, not yet recruiting study with 140 planned participants. Allocation is Randomized, masking is Double, and the intervention model is Parallel Assignment.

The primary endpoint is “Proportion of Participants Achieving PASI 50” over “Week 12.” The retrieved endpoint description is: Proportion of participants who achieve at least a 50% reduction from baseline in Psoriasis Area and Severity Index (PASI) score. PASI is a physician-assessed measure of psoriasis severity based on erythema, induration, scaling, and affected body surface area..

Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 140 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.

No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.

Indexed readouts in the surrounding landscape

5 recent result records were selected as contextual evidence for Plaque psoriasis. These records do not establish direct evidence for NCT07626788 unless the registration number matches.

Real-world outcomes of deucravacitinib in Chinese plaque psoriasis patients: a 24-week prospective study

Phase 4; n=101; PASI75(24-week) = 77.2 % Source: https://pubmed-ncbi-nlm-nih-gov.libproxy1.nus.edu.sg/41769731/

A Phase 3, Multicenter, Open-Label Extension Study of the Long-Term Safety of ARQ-151 Cream 0.3% in Subjects With Chronic Plaque Psoriasis

Phase 3; n=337; Percentage of Participants With ≥1 Treatment-Emergent Adverse Events (TEAEs) = 26.1 percentage of participants ; Percentage of Participants With ≥1 Treatment-Emergent Adverse Events (TEAEs) = 33.3 percentage of participants Source: https://clinicaltrials.gov/ct2/show/results/NCT04286607

Multi-Center, Double-Blind, Randomized, Vehicle-Controlled, Parallel-Group Study to Compare Padagis' Roflumilast Cream 0.3% to Arcutis's Zoryve™ (Roflumilast Cream 0.3%) Cream and…

Phase 3; n=416; IGA = 78 Participants ; IGA = 79 Participants Source: https://clinicaltrials.gov/ct2/show/results/NCT05763082

Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.

Asset and sponsor context

No exact Drug & Asset MCP profile was returned for the protocol wording “Pentoxifylline.” The report therefore avoids inferring modality, target or global development stage from the name alone.

No exact Company & Deal Intelligence profile was returned for University of Phayao. Sponsor identity is retained from the trial protocol without adding unsupported corporate claims.

For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.

Development white space

Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
Sequencing white space. Clarify whether Pentoxifylline is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.

White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.

Strategic implications and next readouts

For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.

For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.

Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.

Source trail and bottom line

Anchor trial: NCT07626788
Protocol source: https://clinicaltrials.gov/study/NCT07626788
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 16 September 2026.

Pentoxifylline in Plaque psoriasis is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Proportion of Participants Achieving PASI 50 and 2027-03-01 the leading decision points.

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