Atezolizumab in Recurrent Glioblastoma: NCT06069726 Clinical Landscape Report 2026
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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.
Data snapshot: 15 October 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.
Phase 2
Clinical phase
Recruiting
Recruitment status
not reported
Planned enrollment
2028-01-01
Primary-completion proxy
Executive view
NCT06069726 evaluates Atezolizumab in Recurrent Glioblastoma. The disclosed sponsor is Duke University, the design is Interventional, and the geographic footprint is United States. The first listed primary endpoint is Median survival within the low and high TMB groups, assessed over Day 1 of atezolizumab treatment until death or off study due to any other reason whichever comes first, assessed for up to 24 months. If the patient is alive at the time of analysis, survival will be censored at the time of last follow-up..
The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.
PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.
How the MCP evidence stack was assembled
Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT06069726 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Recurrent Glioblastoma landscape. Drug & Asset MCP drug_fetch was queried for Atezolizumab, while Company & Deal Intelligence MCP organization_fetch was queried for Duke University.
This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Readout proxy |
|---|---|---|---|---|---|---|
| NCT06069726 | Atezolizumab | Phase 2 / Recruiting | Duke University | United States | Median survival within the low and high TMB groups Day 1 of atezolizumab treatment until death or off study due to any o… | 2028-01-01 |
| NCT06703255 | Temozolomide | Phase 1/2 / Recruiting | Hangzhou Hansi Biological Pharmaceutical Co., Ltd. | China | Part I: Number of participants experiencing Adverse Events (AEs) All AEs up to 28(±7)days after the last dose of study treatment | 2026-12-31 |
| NCT06691308 | WL-276 (Imunopharm) | Early Phase 1 / Not yet recruiting | Beijing Imunopharm Technology Co., Ltd. | Geography not reported | Evaluate the safety（Adverse event incidence rate、Incidence rate of abnormal laboratory test results） and tolerability（D… Within 28 days after infusion | 2027-05-31 |
| NCT06687681 | Allogenic NK cell(Kian Immune Cell Company) | Phase 2 / Recruiting | Kian immune Cell Company | Iran | To measure tumor response after infusion of intrathecal NK cells From enrollment to the end of treatment at 12 months | 2025-11-25 |
| NCT06672575 | Ivonescimab | Phase 1/2 / Recruiting | The University of Texas MD Anderson Cancer Center | United States | Safety and Adverse Events (AEs) Through study completion; an average of 1 year | 2028-01-31 |
The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.
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Protocol design and endpoint interpretation
NCT06069726 is a Phase 2, recruiting study with not reported planned participants. Allocation is N/A, masking is None (Open Label), and the intervention model is Single Group Assignment.
The primary endpoint is “Median survival within the low and high TMB groups” over “Day 1 of atezolizumab treatment until death or off study due to any other reason whichever comes first, assessed for up to 24 months. If the patient is alive at the time of analysis, survival will be censored at the time of last follow-up..” The retrieved endpoint description is: Survival of the prospectively treated patient is defined as the time between initiation of atezolizumab and death. If the patient is alive at the time of analysis, survival will be censored at the time of last follow-up..
Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of not reported should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.
No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.
Indexed readouts in the surrounding landscape
0 recent result records were selected as contextual evidence for Recurrent Glioblastoma. These records do not establish direct evidence for NCT06069726 unless the registration number matches.
Indexed evidence status
No directly comparable result record was retrieved for this disease query. This is a monitoring gap, not evidence of absence.
Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.
Asset and sponsor context
Atezolizumab is indexed as Monoclonal antibody with PDL1 biology and a global stage of Approved. The asset profile lists Genentech, Inc. as an originator or developer.
Duke University is indexed in an unreported country with the website https://www.dukeems.org. Duke University is a private research university providing undergraduate and postgraduate education in medicine and other disciplines. The record lists 65 development-stage drug assets.
For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.
Development white space
- Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
- Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
- Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
- Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
- Sequencing white space. Clarify whether Atezolizumab is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.
White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.
Strategic implications and next readouts
For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.
For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.
Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.
Source trail and bottom line
Anchor trial: NCT06069726
Protocol source: https://clinicaltrials.gov/study/NCT06069726
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 15 October 2026.
Atezolizumab in Recurrent Glioblastoma is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Median survival within the low and high TMB groups and 2028-01-01 the leading decision points.
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