Curcumin Liposomal in Relapse multiple myeloma: NCT07456605 Clinical Landscape Report 2026
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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.
Data snapshot: 18 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.
Phase 1
Clinical phase
Recruiting
Recruitment status
20
Planned enrollment
2028-03-02
Primary-completion proxy
Executive view
NCT07456605 evaluates Curcumin Liposomal in Relapse multiple myeloma. The disclosed sponsor is University Health Network, the design is Interventional, and the geographic footprint is Canada. The first listed primary endpoint is Number of participants who experience Grade 4 neutropenia lasting more than 10 days despite use of growth factors, assessed over 2 years.
The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.
PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.
How the MCP evidence stack was assembled
Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07456605 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Relapse multiple myeloma landscape. Drug & Asset MCP drug_fetch was queried for Curcumin Liposomal, while Company & Deal Intelligence MCP organization_fetch was queried for University Health Network.
This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.
Trial landscape table
| Trial | Asset / intervention | Phase / status | Sponsor | Geography | Primary endpoint | Readout proxy |
|---|---|---|---|---|---|---|
| NCT07456605 | Curcumin Liposomal | Phase 1 / Recruiting | University Health Network | Canada | Number of participants who experience Grade 4 neutropenia lasting more than 10 days despite use of growth factors 2 years | 2028-03-02 |
| NCT07581704 | Sirolimus | Phase 1 / Recruiting | University of Iowa | United States | Phase Ib: Dose limiting toxicities (DLTs) as measured by NCI Common Terminology Criteria for Adverse Events (CTCAE) ver… From treatment initiation through 30 days post last dose of study tre… | 2029-06-01 |
| NCT07577206 | [68Ga]Ga-R54 | Early Phase 1 / Recruiting | National Cancer Institute | Italy | Quantitative analysis of the uptake (pharmacodynamics) of [68Ga]Ga-R54 in the neoplastic lesion by measuring the "maxim… Single time point at PET/CT imaging (Day 1) | 2027-01-01 |
| NCT07558915 | RO-7851624 | Phase 1 / Recruiting | Genentech, Inc. | Australia | Percentage of Participants With Adverse Events (AEs) Up to approximately 2 years | 2030-07-01 |
| NCT07541391 | KMA.CAR T(HaemaLogiX) | Phase 1 / Recruiting | Peter MacCallum Cancer Institute | Australia | To evaluate the safety of autologous PMCC-COE-KMA in patients with RR MM following lymphodepletion, identifying the max… From enrollment to the first 28 days after the PMCC-COE-KMA infusion | 2028-09-01 |
The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.
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Protocol design and endpoint interpretation
NCT07456605 is a Phase 1, recruiting study with 20 planned participants. Allocation is Non-Randomized, masking is None (Open Label), and the intervention model is Sequential Assignment.
The primary endpoint is “Number of participants who experience Grade 4 neutropenia lasting more than 10 days despite use of growth factors” over “2 years.” No additional primary-endpoint description was returned in the selected field set.
Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 20 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.
No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.
Indexed readouts in the surrounding landscape
5 recent result records were selected as contextual evidence for Relapse multiple myeloma. These records do not establish direct evidence for NCT07456605 unless the registration number matches.
Open Label, Phase 2, Single-Arm Study of Selinexor, Daratumumab, Carfilzomib and Dexamethasone for High-Risk, Relapsed and Relapsed/Refractory Multiple Myeloma Patients Who Have R…
Phase 2; n=8; ORR = 75.0 percentage of participants (95% Confidence Interval, 34.9 - 96.8) Source: https://clinicaltrials.gov/ct2/show/results/NCT04756401
MATCH Treatment Subprotocol Z1E: Larotrectinib (LOXO-101) in Patients With Tumors With NTRK Fusions
Phase 2; n=16; ORR = 75 percentage of participants (90% Confidence Interval, 47.3 - 92.8) Source: https://clinicaltrials.gov/ct2/show/results/NCT06390852
A Phase III Randomized, Controlled, Multicenter, Open-label Study of ATG-010, Bortezomib, and Dexamethasone (SVd) Versus Bortezomib and Dexamethasone (Vd) in Patients With Relapse…
Phase 3; n=154; PFS(Median) = 6.34 month (95% Confidence Interval, 5.55 - 11.79); PFS(Median) = 8.11 month (95% Confidence Interval, 6.28 - 11.99) Source: https://clinicaltrials.gov/ct2/show/results/NCT04939142
Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.
Asset and sponsor context
Curcumin Liposomal is indexed as Small molecule drug with DNMT1 x RBM3 x TGF-β x TLR4 x VEGF biology and a global stage of Pending. The asset profile lists SignPath Pharma, Inc. as an originator or developer.
University Health Network is indexed in Canada with the website http://www.uhn.ca. Operates as a research and teaching hospital network that provide health care and medical services The record lists 19 development-stage drug assets.
For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.
Development white space
- Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
- Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
- Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
- Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
- Sequencing white space. Clarify whether Curcumin Liposomal is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.
White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.
Strategic implications and next readouts
For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.
For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.
Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.
Source trail and bottom line
Anchor trial: NCT07456605
Protocol source: https://clinicaltrials.gov/study/NCT07456605
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 18 September 2026.
Curcumin Liposomal in Relapse multiple myeloma is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Number of participants who experience Grade 4 neutropenia lasting more than 10 days despite use of growth factors and 2028-03-02 the leading decision points.
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