Vorolanib NCT06577961 Clinical Landscape 2026

Explore the PatSnap Life Sciences MCP marketplace

This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.

Data snapshot: 15 October 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.

Phase 1/2

Clinical phase

Not yet recruiting

Recruitment status

not reported

Planned enrollment

2027-08-31

Primary-completion proxy

Executive view

NCT06577961 evaluates Vorolanib in Renal Cell Carcinoma. The disclosed sponsor is Cancer Hospital Chinese Academy of Medical Sciences, the design is Interventional, and the geographic footprint is Geography not reported. The first listed primary endpoint is Objective Response Rate assessed by RECIST 1.1, assessed over 12 months.

The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.

PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.

How the MCP evidence stack was assembled

Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT06577961 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Renal Cell Carcinoma landscape. Drug & Asset MCP drug_fetch was queried for Vorolanib, while Company & Deal Intelligence MCP organization_fetch was queried for Cancer Hospital Chinese Academy of Medical Sciences.

This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.

Trial landscape table

Trial	Asset / intervention	Phase / status	Sponsor	Geography	Primary endpoint	Readout proxy
NCT06577961	Vorolanib	Phase 1/2 / Not yet recruiting	Cancer Hospital Chinese Academy of Medical Sciences	Geography not reported	Objective Response Rate assessed by RECIST 1.1 12 months	2027-08-31
NCT06708949	Ipilimumab	Phase 2 / Active, not recruiting	M.D. Anderson International España SA	United States	Safety and Averse events (AEs) Through study completion; an average of 1 year	2028-12-15
NCT06699602	Cemiplimab-RWLC	Phase 2 / Recruiting	Memorial Sloan Kettering Cancer Center	United States	response 1 year	2028-02-01
NCT06690697	Toripalimab	Phase 2 / Recruiting	Fudan University	China	Overall Response Rate (ORR) 2 years	2026-06-30
NCT06680089	[18F]RCCB6	Phase 2 / Recruiting	Sponsor not reported	China	Biodistribution of [18F]RCCB6 1 day from injection of the tracer	2026-11-01

The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.

Reproduce the trial-to-asset workflow with PatSnap MCP

Protocol design and endpoint interpretation

NCT06577961 is a Phase 1/2, not yet recruiting study with not reported planned participants. Allocation is N/A, masking is None (Open Label), and the intervention model is Single Group Assignment.

The primary endpoint is “Objective Response Rate assessed by RECIST 1.1” over “12 months.” The retrieved endpoint description is: ORR, per RECIST 1.1 calculated as the proportion of patients with a best overall response defined as complete response (CR) or partial response (PR)..

Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of not reported should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.

No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.

Indexed readouts in the surrounding landscape

100 recent result records were selected as contextual evidence for Renal Cell Carcinoma. These records do not establish direct evidence for NCT06577961 unless the registration number matches.

A mixed inflammatory peripheral signature defines clinical outcomes in a phase II trial combining pembrolizumab with paclitaxel and carboplatin in melanoma

Phase 2; n=30; AE(Grade 3 and higher) = 50.0 % Source: https://pubmed-ncbi-nlm-nih-gov.libproxy1.nus.edu.sg/41732954/

Immune Checkpoint Inhibitor Myositis, Myocarditis, and Myasthenia Gravis: a comparison of overall survival using real world data

Not Applicable; n=318391; Median time from ICI initiation to irAE onset = 42.1 Day ; Median time from ICI initiation to irAE onset = 230.2 Day Source: https://acrabstracts.org/abstract/immune-checkpoint-inhibitor-myositis-myocarditis-and-myasthenia-gravis-a-comparison-of-overall-survival-using-real-world-data/

Rheumatoid Arthritis does not negatively impact overall survival in patients with Renal Cell Carcinoma treated with Immune Checkpoint Inhibitors- a real-world data study

Not Applicable; n=27394; DMARD use = 0.1 % ; DMARD use = 14.0 % Source: https://acrabstracts.org/abstract/rheumatoid-arthritis-does-not-negatively-impact-overall-survival-in-patients-with-renal-cell-carcinoma-treated-with-immune-checkpoint-inhibitors-a-real-world-data-study/

Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.

Asset and sponsor context

Vorolanib is indexed as Small molecule drug with PDGFRs x VEGFR biology and a global stage of Approved. The asset profile lists Tyrogenex, Inc. as an originator or developer.

Cancer Hospital Chinese Academy of Medical Sciences is indexed in an unreported country with the website https://www.cicams.ac.cn. The organization record is used to resolve sponsor identity. The record lists 27 development-stage drug assets.

For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.

Development white space

Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
Sequencing white space. Clarify whether Vorolanib is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.

White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.

Strategic implications and next readouts

For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.

For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.

Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.

Source trail and bottom line

Anchor trial: NCT06577961
Protocol source: https://clinicaltrials.gov/study/NCT06577961
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 15 October 2026.

Vorolanib in Renal Cell Carcinoma is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Objective Response Rate assessed by RECIST 1.1 and 2027-08-31 the leading decision points.

Build and refresh clinical landscape reports with PatSnap MCP