Bio Sequence

Contemporary Competitive Scenario: Analyzing Roche's Emergent Product, Trontinemab

27 October 2023
3 min read

A year prior, Roche publicly announced at an Alzheimer's disease conference held in San Francisco that its prospective gantenerumab - an antibody developed against amyloid protein, displayed no significant improvement in cognitive decline as per a pivotal study involving 2,000 patients. The experiment's results, showing a lower-than-anticipated removal of the amyloid protein, led Roche to suspend additional research on this medication.

However, Roche remained undeterred in pursuing groundbreaking research and development within this disease domain. At this year's Clinical Trials on Alzheimer's Disease (CTAD) conference, Roche gathered initial data on a refined antibody deriving from gantenerumab. This transformed version, however, was designed to permeate the protective blood-brain barrier with more ease than its predecessor.

That new drug, called trontinemab, displays an eight-fold increase in concentration within the cerebrospinal fluid compared to gantenerumab. At the conference, Roche announced that after 28 weeks, 75% of the patients who were administered the highest dosage among three different dosages exhibited amyloid protein levels beneath the average detection level.

A Panoramic View of Trontinemab’s Top 10 Patent Assignees

图表

低可信度描述已自动生成

Source, Patsnap Bio

Evolution of the Layout of Top 10 Patent Assignees over the years, the Competitive landscape over time

Exploring the changes occurring within the application structure amongst Trontinemab's top 10 patent assignees over time delivers insights into the competitive landscape's evolution.

Source, Patsnap Bio

So, How Can You Access Comprehensive Data on Trontinemab Sequence Patents at No Cost?

Firstly, establish a free account with Patsnap Bio Sequence Database. Proceed to the homepage's "standard search," and enter the Trontinemab sequence or directly input the drug name, Trontinemab, in the "Drug/Gene index. This single action will unravel extensive details of Trontinemab's sequence, patent, literature, data from diversified sources, and a visually competitive landscape of patents.

图形用户界面, 文本, 应用程序

描述已自动生成

图形用户界面, 应用程序

描述已自动生成

图形用户界面, 文本, 应用程序, 电子邮件

描述已自动生成

The left panel's search result details page is equipped with an exhaustive range of filters, enabling you to pinpoint specific data accurately, thereby boosting your search experience and overall efficiency. Clicking on each data point will unfold a rich and detailed data set and a host of advantageous and practical tools to support your research process.

It is important to note that Patsnap Bio is the most extensive sequence search platform for the Patsnap database. It incorporates AI with human-curated data for comprehensive handling of protein and nucleotide sequence data plucked from global patents, biological periodicals, and public repositories. Essential biological sequences are manually annotated, illuminating structural modifications to provide the most accurate sequence data and boost sequence retrieval efficiency.

Free registration is available for the Bio biological sequence database: https://bio-patsnap-com.libproxy1.nus.edu.sg. Act now to expedite your sequence search tasks.

The marketing application for Huadong Medicine's FRα ADC Mirvetuximab Soravtansine Injection has been accepted
Latest Hotspot
3 min read
The marketing application for Huadong Medicine's FRα ADC Mirvetuximab Soravtansine Injection has been accepted
27 October 2023
On Oct 25, 2023, Huadong Medicine's subsidiary, Hangzhou Zhongmeihuadong Pharmaceutical, was granted a "Notice of Acceptance" by the NMPA for their marketing application for Mirvetuximab Soravtansine Injection (IMGN853, HDM2002), co-developed with ImmunoGen.
Read →
Biological Glossary | What are Complementarity-determining regions (CDRs)?
Bio Sequence
2 min read
Biological Glossary | What are Complementarity-determining regions (CDRs)?
27 October 2023
Complementarity-determining regions (CDRs) are essential components of the variable chains found in immunoglobulins (antibodies) and T cell receptors.
Read →
Celltrion's Infliximab (subcutaneous formulation) receives FDA approval for the treatment of inflammatory bowel disease
Latest Hotspot
3 min read
Celltrion's Infliximab (subcutaneous formulation) receives FDA approval for the treatment of inflammatory bowel disease
27 October 2023
On Oct 25, 2023, Celltrion reported US FDA approval of Zymfentra (infliximab) for continued treatment of adult ulcerative colitis (UC) and Crohn's disease (CD) after intravenous infliximab treatment.
Read →
Biological Glossary | What is Attenuator?
Bio Sequence
3 min read
Biological Glossary | What is Attenuator?
27 October 2023
Attenuator in biotechnology refers to a nucleotide sequence in DNA that can lead to premature termination of transcription, a process found in bacteria and archaea.
Read →
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.