2-Deoxyglucose Drug Asset Due Diligence Report 2026

This 2-Deoxyglucose Drug Asset Due Diligence Report was built with PatSnap Life Sciences MCP workflows. Drug & Asset MCP establishes identity, ownership and stage; Clinical Trials MCP checks design, endpoints and readouts; Company & Deal Intelligence MCP reconstructs transaction precedent. Explore the MCP servers used in this report.

Decision date: 23 July 2026. Currency fields are presented in US$ millions as returned by the deal dataset. This is a screening memorandum, not legal, medical, patent or investment advice.

Approved

Highest phase

Registered trials

Result records

Matched deals

Executive recommendation: GO

Decision memo

Advance diligence: development maturity and available evidence support continued investment, subject to indication-specific safety, IP, and commercial gates.

The central underwriting question is whether 2-Deoxyglucose can convert its Small molecule drug profile and HK2 biology into clinically meaningful differentiation while preserving an investable safety, IP and commercial position.

1. Asset identity and development status

Asset	2-Deoxyglucose (query alias: 2-Deoxyglucose)
Modality / target	Small molecule drug; HK2; HK2 inhibitors, Glycolysis inhibitors, Virus replication inhibitors
Highest global status	Approved
Originator	University of Wisconsin-Madison
Active developers	Korea Institute of Radiological & Medical Sciences, Third Military Medical University, The University of Miami Leonard M. Miller School of Medicine

The MCP disease footprint includes COVID-19, Acute Myeloid Leukemia, Hepatocellular Carcinoma. The highest-phase flag is a useful orientation point, but the licensing case depends on indication-level evidence and rights, not the global label alone.

2. Clinical program: design and endpoint audit

Registry	Phase	Status	Enrollment	Lead primary endpoint
NCT06375772	Phase 2	Terminated	64	The difference in the rate of rhinovirus-associated illness between 2-DG and placebo
NCT05605301	Phase 2	Completed	9	Area Under the Curve From Time Zero to Last Observed Time Point (AUClast)
ACTRN12624001290583	Phase 1	Not yet recruiting	18	Not disclosed

The trial set should be diligenced for randomization, comparator relevance, endpoint hierarchy, analysis population, multiplicity, geographic mix and readout timing. For early-stage studies, safety and dose selection can be as decision-critical as response rate.

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3. Clinical readouts: what is known

Pharmacokinetics Study of Oral 2-Deoxy-D-Glucose (2DG) in Subjects With a Confirmed Diagnosis of Epilepsy

Phase 2; n=9; evaluation: not stated. Reported fields: Area Under the Curve From Time Zero to Last Observed Time Point (AUClast)(Mean) = 2.81 hour*ug/mL (Standard Deviation, 0.49); -; Area Under the Curve From Time Zero to Last Observed Time Point (AUClast)(Mean) = 2.93 hour*ug/mL (Standard Deviation, 1.13)

A Phase I/II Trial of 2-Deoxyglucose (2DG) for the Treatment of Advanced Cancer and Hormone Refractory Prostate Cancer

Phase 1/2; n=12; evaluation: not stated. Reported fields: -; -; PFS = 9 Participants

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

Phase 1; n=not disclosed; evaluation: not stated. Reported fields: MTD(maximum tolerated dose) = 63 mg/kg/day

These fields are structured evidence signals, not a substitute for statistical review. The next diligence pass should reconcile denominators, confidence intervals, follow-up, censoring, dose cohorts and treatment-emergent toxicity against the original abstract, registry and protocol.

4. Market and competitive position

2-Deoxyglucose addresses COVID-19, Acute Myeloid Leukemia, Hepatocellular Carcinoma. Commercial attractiveness rests on addressable biomarker-positive patients, treatment-line placement, duration, administration burden, pricing and displacement of entrenched standards. The modality—Small molecule drug—must demonstrate a benefit large enough to offset class-specific safety and operational costs.

The strongest market-validation signal in this screen is partner behavior: 1 matched transaction record(s) indicate that sophisticated counterparties have assigned strategic value to the asset or its rights. That does not establish net present value; probability of success, remaining R&D spend, royalties, cost sharing and territorial scope still need modeling.

5. Transaction precedent and economics

Date	Transaction	Phase at deal	Disclosed economics
2021-07-29	Dr. Reddy's and INMAS collaborate to develop 2-deoxy-D-glucose for COVID-19.	Approved	Financial terms not disclosed

Headline values are not directly comparable. Diligence should normalize upfront cash, equity, development and sales milestones, tiered royalties, opt-in mechanics, cost sharing, change-of-control clauses and geography.

6. IP and freedom-to-operate screen

No asset-specific patent-application milestone appeared in the returned milestone slice. That absence is not a freedom-to-operate conclusion; a dedicated family, claim, ownership, expiry, and legal-status search remains mandatory before signing.

The claim chart should separately test composition or sequence coverage, formulation and dosing, indication and biomarker claims, combinations, manufacturing know-how, prosecution history, term extensions and third-party blocking rights. Confirm that licensed patents, data and know-how track every granted territory and field.

7. Principal risks and diligence gates

Therapeutic index across KRAS/BRAF mutation subgroups
On-target toxicity and adaptive MAPK resistance
Lack of matched efficacy results in the current MCP result set

Cross-functional diligence should also test CMC comparability, supply chain, pharmacovigilance, regulatory correspondence, data integrity, investigator concentration, partner obligations and change-of-control restrictions.

8. Final go/no-go memorandum

GO