IMA-402 Drug Asset Due Diligence Report 2026: Clinical, IP, Market, Deals, and Go/No-Go
This IMA-402 Drug Asset Due Diligence Report was built with PatSnap Life Sciences MCP workflows. Drug & Asset MCP establishes identity, ownership and stage; Clinical Trials MCP checks design, endpoints and readouts; Company & Deal Intelligence MCP reconstructs transaction precedent. Explore the MCP servers used in this report.
Decision date: 11 September 2026. Currency fields are presented in US$ millions as returned by the deal dataset. This is a screening memorandum, not legal, medical, patent or investment advice.
Executive recommendation: CONDITIONAL GO
Decision memo
Advance with milestone-based economics while efficacy durability, safety differentiation, patent scope, and market positioning are validated.
The central underwriting question is whether IMA-402 can convert its Bispecific T-cell Engager (BiTE) profile and CD3 x PRAME biology into clinically meaningful differentiation while preserving an investable safety, IP and commercial position.
1. Asset identity and development status
| Asset | IMA-402 (query alias: IMA-402) |
|---|---|
| Modality / target | Bispecific T-cell Engager (BiTE); CD3 x PRAME; CD3 stimulants, PRAME modulators, T lymphocytes stimulants |
| Highest global status | Phase 1/2 |
| Originator | Immatics Biotechnologies GmbH |
| Active developers | Immatics Biotechnologies GmbH |
The MCP disease footprint includes Refractory Cancer, Solid tumor. The highest-phase flag is a useful orientation point, but the licensing case depends on indication-level evidence and rights, not the global label alone.
2. Clinical program: design and endpoint audit
| Registry | Phase | Status | Enrollment | Lead primary endpoint |
|---|---|---|---|---|
| NCT05958121 | Phase 1/2 | Recruiting | 400 | Primary endpoint not disclosed in English source |
The trial set should be diligenced for randomization, comparator relevance, endpoint hierarchy, analysis population, multiplicity, geographic mix and readout timing. For early-stage studies, safety and dose selection can be as decision-critical as response rate.
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3. Clinical readouts: what is known
Immatics Achieves Clinical Proof-of-Concept of its Next-Generation TCR Bispecific (TCER®) Pipeline with Data on IMA402 (PRAME) and IMA401 (MAGEA4/8) and Announces Next Development Steps
Phase 1; n=80; evaluation: Positive. Reported fields: cORR = 4 Pts ; cORR = 2 Pts
Immatics Announces Third Quarter 2024 Financial Results, Business Update and First Clinical Data on TCER® IMA402 Targeting PRAME
Phase 1; n=33; evaluation: Positive. Reported fields: TS(Proportion of patients) = 14 % ; TS(Proportion of patients) = 25 %
753P - Targeting solid tumors with IMA402, a next-generation bispecific T cell engaging receptor against PRAME
Phase 1; n=not disclosed; evaluation: Not stated in English source. Reported fields: In vitro anti-tumor activity = picomolar concentration
These fields are structured evidence signals, not a substitute for statistical review. The next diligence pass should reconcile denominators, confidence intervals, follow-up, censoring, dose cohorts and treatment-emergent toxicity against the original abstract, registry and protocol.
4. Market and competitive position
IMA-402 addresses Refractory Cancer, Solid tumor. Commercial attractiveness rests on addressable patients, treatment-line placement, duration, administration burden, pricing and displacement of entrenched standards. The modality—Bispecific T-cell Engager (BiTE)—must demonstrate a benefit large enough to offset class-specific safety and operational costs.
The MCP screen returned 140 matched transaction record(s) under the scope “target-level comparable: CD3 x PRAME.” Partner activity is a market-validation signal, but it does not establish net present value.
5. Transaction precedent and economics
Transaction-scope note: No direct asset-specific transaction was returned. The table below shows target-level comparable: CD3 x PRAME records as comparable precedents only.
| Date | Transaction | Phase at deal | Disclosed economics |
|---|---|---|---|
| 2026-09-01 | Simcere Zaiming Enters Exclusive License Agreement with Roche for SIM0660 Global Development | Preclinical | US$75.0M upfront; US$1,530.0M stated total |
| Not disclosed | IASO Bio Completes Acquisition of Singapore's MediSix Therapeutics to Expand Cell Therapy Platform | Preclinical | Financial terms not disclosed |
| 2026-07-29 | AbCellera Announces Collaboration with Vertex to Discover Multispecific T-Cell Engagers for Autoimmune Diseases and Other Conditions | Discovery | US$28.0M upfront |
Headline values are not directly comparable. Diligence should normalize upfront cash, equity, development and sales milestones, tiered royalties, opt-in mechanics, cost sharing, change-of-control clauses and geography.
6. IP and freedom-to-operate screen
No asset-specific patent-application milestone appeared in the returned milestone slice. That absence is not a freedom-to-operate conclusion; a dedicated family, claim, ownership, expiry, and legal-status search remains mandatory before signing.
The claim chart should separately test composition or sequence coverage, formulation and dosing, indication and biomarker claims, combinations, manufacturing know-how, prosecution history, term extensions and third-party blocking rights.
7. Principal risks and diligence gates
- Cytokine-release syndrome, neurotoxicity, infection, and treatment logistics
- Durability of response and antigen escape
- Manufacturing scalability, release testing, and site readiness
Cross-functional diligence should also test CMC comparability, supply chain, pharmacovigilance, regulatory correspondence, data integrity, investigator concentration, partner obligations and change-of-control restrictions.
8. Final go/no-go memorandum
CONDITIONAL GO
Advance with milestone-based economics while efficacy durability, safety differentiation, patent scope, and market positioning are validated.
Required pre-signing gates: reproduce key efficacy analyses; complete an indication-specific safety review; run a full patent-family and freedom-to-operate search; model risk-adjusted economics by territory; and reconcile all rights, sublicenses and encumbrances.
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Data provenance: PatSnap Drug & Asset MCP, Clinical Trials MCP, and Company & Deal Intelligence MCP; accessed 2026-09-11. Counts and status fields may change as source records update.
