Pharma Pioneer

Nanobiotix Concludes Phase 1 Dose Escalation, Determines Phase 2 Dose for NBTXR3 in Re-Irradiation-Eligible Recurrent Lung Cancer

17 May 2024
2 min read

April 2, 2024 — NANOBIOTIX, a late-clinical stage biotechnology company, has completed the dose escalation phase of a Phase 1 study evaluating NBTXR3, a potential first-in-class radioenhancer, for patients with inoperable, recurrent non-small cell lung cancer (NSCLC) who have previously received definitive radiation therapy. The study, conducted by The University of Texas MD Anderson Cancer Center, established the recommended Phase 2 dose of NBTXR3 and confirmed the injection's feasibility and favorable safety profile, indicating potential for later stage development.
The dose expansion part of the Phase 1 study is currently ongoing to further assess the safety and evaluate early signals of efficacy. NBTXR3 is composed of functionalized hafnium oxide nanoparticles administered via one-time intratumoral injection and activated by radiotherapy. It has shown potential to induce significant tumor cell death when activated by radiotherapy and trigger an adaptive immune response.
The primary objectives of the study include assessing the safety of re-irradiation in patients with inoperable, recurrent NSCLC and determining the recommended Phase 2 dose of NBTXR3. The re-irradiation safety assessment and dose-finding parts of the study have been completed, with an expansion part evaluating additional signals of safety, feasibility, anti-tumor response, and time-to-event outcomes currently in progress.
NBTXR3 has received a European CE mark for the treatment of patients with soft tissue sarcoma and is being evaluated across multiple solid tumor indications, both as a single agent and in combination with anti-PD-1 immune checkpoint inhibitors. NANOBIOTIX is a clinical biotechnology company focused on pioneering physics-based therapeutic approaches to improve treatment outcomes for cancer patients. The company's lead product candidate, NBTXR3, has achieved market authorization in Europe under the brand name Hensify®.

How to obtain the latest research advancements in the field of biopharmaceuticals?

In the Synapse database, you can keep abreast of the latest research and development advances in drugs, targets, indications, organizations, etc., anywhere and anytime, on a daily or weekly basis. Click on the image below to embark on a brand new journey of drug discovery!

图形用户界面, 文本, 应用程序, 聊天或短信

描述已自动生成

Corbus Commences U.S. Phase 1 Trial with First Patient Dosed for Next-Gen Nectin-4 ADC CRB-701
Pharma Pioneer
2 min read
Corbus Commences U.S. Phase 1 Trial with First Patient Dosed for Next-Gen Nectin-4 ADC CRB-701
17 May 2024
Corbus Pharmaceuticals, a precision oncology firm, has initiated a Phase 1 clinical trial in the U.S. for CRB-701 (SYS6002)
Read →
Verve Therapeutics Pauses Gene-Editing Clinical Trial Following Patient's Adverse Reaction
Pharma Pioneer
2 min read
Verve Therapeutics Pauses Gene-Editing Clinical Trial Following Patient's Adverse Reaction
17 May 2024
A clinical trial for a gene-editing treatment by Verve Therapeutics, known as VERVE-101, has been halted after a participant experienced severe side effects.
Read →
Ractigen Commences Phase I Clinical Trial with First Patient Treated for NMIBC Using RAG-01
Pharma Pioneer
2 min read
Ractigen Commences Phase I Clinical Trial with First Patient Treated for NMIBC Using RAG-01
17 May 2024
In a significant medical advancement, Ractigen Therapeutics has initiated its first-ever human clinical trial for RAG-01, a novel small activating RNA (saRNA) treatment for NMIBC.
Read →
Verismo Submits FDA Application for IND Approval of SynKIR™-310 for Treating Recurrent or Refractory B-cell NHL
Pharma Pioneer
2 min read
Verismo Submits FDA Application for IND Approval of SynKIR™-310 for Treating Recurrent or Refractory B-cell NHL
17 May 2024
Verismo Therapeutics, a company specializing in CAR T-cell therapies, is progressing with its second clinical trial using the SynKIR™ platform.
Read →
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.