Infertility, Male

Conduit also appoints prominent intellectual property attorney Jeffrey Lindeman as a Consultant Leadership additions underscore Conduit’s commitment to strengthening and broadening its intellectual property portfolio through solid-form technology to maximize future value SAN DIEGO and LONDON, March 19, 2024 (GLOBE NEWSWIRE) -- Conduit Pharmaceuticals Inc. (Nasdaq: CDT) ("Conduit Pharmaceuticals" or "Conduit" or the “Company”) today announced the appointment of Dr. Joanne Holland as Chief Scientific Officer. Dr. Holland brings over 20 years of experience to the CSO role at Conduit, having amassed expertise across the entire development spectrum. This includes a deep knowledge base in identifying drugs that can be applied across multiple disease states, combining research and commercial skills to advance drugs to market, and working with premier scientific thought leaders. She has a specific focus in solid-form technology and its associated intellectual property, having held leadership positions at publicly traded companies in this space, as well as consulting roles for several pharmaceutical companies on all matters relating to solid-form technology. She has successfully shepherded multiple solid-form candidates from discovery stage into the clinic, and is the author of over 50 solid-form intellectual property patents. Dr. Holland earned a PhD in chemistry from the University of Leeds, UK, which was sponsored by Pfizer, Inc., before starting her career at companies including Millennium Pharmaceuticals and Stylacats Limited. In addition, Conduit has engaged Dr. Jeff Lindeman to consult on intellectual property strategies as part of the Company’s research and development of its solid-form candidates. An international speaker, Dr. Lindeman has authored book chapters on patent strategies relating to pharmaceutical solid-state forms. Prior to opening his consulting firm Two Notch Solutions, LLC, in 2009, Dr. Lindeman founded and then successfully sold J.A. Lindeman & Co. PLLC (now Raphael Bellum PLLC) and has over 30 years of intellectual property law experience, including as an adjunct patent law professor at American University and as a United States patent examiner. His role with the Company is as a consultant, not legal counsel. “The appointment of Jo as Chief Scientific Officer underscores Conduit’s commitment to optimizing the value of our current intellectual property assets, while concurrently fostering the creation of new intellectual property,” said Dr. David Tapolczay, Chief Executive Officer. “Jo and Jeff have over 20 years of experience working together, and their new leadership roles will significantly enhance our intellectual property state, strategically positioning Conduit for future out-licensing opportunities.” About Conduit Pharmaceuticals Conduit Pharmaceuticals (Nasdaq: CDT) have developed a unique business model to bring medicines to patients. Its novel approach addresses unmet medical need and lengthens the intellectual property for its existing assets through cutting-edge solid-form technology and then commercializes these products with life science companies. Conduit is led by a highly experienced team of pharmaceutical executives, including CEO, Dr. David Tapolczay, former Chief Executive Officer of UK-based medical research charity LifeArc; and the Chair of our Board, Dr. Freda Lewis-Hall, former Chief Medical Officer of Pfizer, Inc. Our Phase II ready pipeline, which consists of a HK4 Glucokinase Activator targeting auto-immune diseases and an MPO Inhibitor which we believe has the potential to treat Idiopathic Male Infertility, has undergone 20+ Phase I trials in over 1,000 patients. Forward-Looking Statements This press release contains certain forward-looking statements within the meaning of the federal securities laws. All statements other than statements of historical facts contained in this press release, including statements regarding Conduit's future results of operations and financial position, Conduit's business strategy, prospective product candidates, product approvals, research and development costs, timing and likelihood of success, plans and objectives of management for future operations, future results of current and anticipated studies and business endeavours with third parties, and future results of current and anticipated product candidates, are forward-looking statements. These forward-looking statements generally are identified by the words "believe," "project," "expect," "anticipate," "estimate," "intend," "strategy," "future," "opportunity," "plan," "may," "should," "will," "would," "will be," "will continue," "will likely result," and similar expressions. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including, but not limited to; the inability to maintain the listing of Conduit's securities on Nasdaq; the ability to recognize the anticipated benefits of the business combination completed in September 2023, which may be affected by, among other things, competition; the ability of the combined company to grow and manage growth economically and hire and retain key employees; the risks that Conduit's product candidates in development fail clinical trials or are not approved by the U.S. Food and Drug Administration or other applicable authorities on a timely basis or at all; changes in applicable laws or regulations; the possibility that Conduit may be adversely affected by other economic, business, and/or competitive factors; and other risks and uncertainties to be identified in the proxy statement/prospectus (as amended and supplemented) relating to the business combination completed in September 2023, including those under "Risk Factors" therein, and in other filings made by Conduit with the U.S. Securities and Exchange Commission. Moreover, Conduit operates in a very competitive and rapidly changing environment. Because forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified and some of which are beyond Conduit's control, you should not rely on these forward-looking statements as predictions of future events. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and except as required by law, Conduit assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. Conduit gives no assurance that it will achieve its expectations. Media: Sean Leous ICR Westwicke Sean.Leous@westwicke.com +1.646.866.4012 Investors: Bill Begien Conduit Pharmaceuticals Inc. bb@conduitpharma.com

-- CEO Kathy Lee-Sepsick and Chief Medical Officer James Liu to Join Jones Trading Analyst Catherine Novack in a Conversation on Current Treatment Options in Infertility Including FemaSeed® at 1PM ET -- ATLANTA, March 13, 2024 (GLOBE NEWSWIRE) -- Femasys Inc. (NASDAQ: FEMY), a biomedical company focused on meeting the significant unmet needs for women worldwide with a broad portfolio of in-office, accessible and innovative therapeutic and diagnostic products, announces it will participate in a Fireside Chat with Jones Trading Analyst Catherine Novack to discuss the current treatment landscape for infertility treatment in women. Those interested in attending the event, which will be held virtually on March 21, 2024 at 1PM ET, may register here. Femasys CEO Kathy Lee-Sepsick and Chief Medical Officer James Liu, M.D. will focus on the current treatment options in the infertility services market, including Femasys’ FDA-authorized FemaSeed device for intratubal insemination. During the event, speakers will also examine emerging trends and technology that have contributed to the growing utilization of assisted reproductive technology (ART), as well as headwinds such as rising costs of IVF in the current climate. Ms. Lee-Sepsick is the founder of Femasys and has nearly three decades of experience as a senior executive in the medical technology industry. She is the lead inventor of the technologies at Femasys and remains committed to advancing much needed technology in women’s health. Prior to his role at Femasys, Dr. Liu has served as Chairman, Department of Obstetrics and Gynecology at University Hospital Health System, the Chair, Department of Reproductive Biology at Case Western Reserve University, and the Division Head, Reproductive Endocrinology and Infertility at the University of Cincinnati. About FemaSeed FemaSeed® is an innovative infertility treatment designed to deliver sperm to the fallopian tube where conception occurs. It is intended to enhance natural fertilization and provide a first-line treatment option for those seeking pregnancy. FemaSeed is less invasive and more affordable than assisted reproduction procedures, such as IVF or ICSI. FemaSeed achieved U.S. FDA clearance (September 2023) and regulatory approval in Canada (April 2023) for patients seeking insemination. At the end of the fourth quarter of 2023, Femasys completed a pivotal clinical trial (LOCAL trial) for those seeking intratubal insemination with a specific focus on male factor infertility, a contributing factor in approximately 40-50% of infertility cases. Top-line data from this study is planned for release first quarter 2024 and will support the commercial launch targeted for the first half of 2024. About Femasys Femasys is a biomedical company focused on meeting significant unmet needs for women worldwide with a broad portfolio of in-office, accessible solutions, including a lead revolutionary product candidate and FDA-cleared, innovative therapeutic and diagnostic products. Femasys’ FemBloc® permanent birth control in late-stage clinical development is the first and only non-surgical, in-office, permanent birth control method intended to be a safer option for women at substantially less cost than the long-standing surgical alternative. Femasys’ FemaSeed® Intratubal Insemination, an innovative infertility treatment designed to deliver sperm directly where conception occurs, is FDA-cleared and has received regulatory approval in Canada. The Company has developed diagnostic products that are complementary for which it has achieved regulatory approvals to market in the U.S., Canada, and other ex-U.S. territories, and which are commercial-ready due to its in-house manufacturing capabilities. The Company’s diagnostic products include FemVue® for fallopian tube assessment by ultrasound, which can be used in conjunction with FemCath®, an intrauterine catheter for selective fallopian tube evaluation, and FemCerv®, an endocervical tissue sampler for cervical cancer diagnosis. Learn more at , or follow us on X, Facebook and LinkedIn. Forward-Looking Statements This press release contains forward-looking statements that are subject to substantial risks and uncertainties. Forward-looking statements can be identified by terms such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “pending,” “intend,” “believe,” “potential,” “hope,” or “continue” or the negative of these terms or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements are based on our current expectations and are subject to inherent uncertainties, risks and assumptions, many of which are beyond our control, difficult to predict and could cause actual results to differ materially from what we expect. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Factors that could cause actual results to differ include, among others: our ability to develop and advance our current product candidates and programs into, and successfully initiate, enroll and complete, clinical trials; the ability of our clinical trials to demonstrate safety and effectiveness of our product candidates and other positive results; estimates regarding the total addressable market for our product candidates; our ability to commercialize our product candidates, or the effect of delays in commercializing; our business model and strategic plans for our products, technologies and business, including our implementation thereof; and those other risks and uncertainties described in the section titled "Risk Factors" in our Annual Report on Form 10-K for the year ended December 31, 2022 and other reports as filed with the SEC. Forward-looking statements contained in this press release are made as of this date, and Femasys undertakes no duty to update such information except as required under applicable law. Contacts: Investors: Gene Mannheimer IR@femasys.com Media Contact: Kati Waldenburg Media@femasys.com

A new study from UCLA and MicroGenDX shows that bacteria may be one of the factors holding back male fertility ORLANDO, FL / ACCESSWIRE / January 31, 2024 / A groundbreaking study conducted by researchers at the University of California Los Angeles (UCLA) and MicroGenDX unveils a potential link between bacterial profiles and male infertility. The collaborative effort, highlighted in the study Semen microbiota are dramatically altered in men with abnormal sperm parameters by Osadchiy et al., sheds crucial light on microbial variations associated with abnormal sperm parameters. This significant discovery not only deepens our comprehension of male infertility, but also provides a new exploratory avenue for treatments facilitated by MicroGenDX's advanced testing. Figure 3 From Study Differential Relative Abundance. Only statistically significant differences are shown. Figure 1A-C, represent the comparisons of groups 1, 2 and 3, respectively. While pollution and other environmental factors have long been recognized as contributors to declining sperm counts, the revelation of bacterial involvement poses a new challenge in the battle against male infertility. Male fertility concerns have historically weighed heavily on individuals whose aspirations of fatherhood are jeopardized by factors often beyond their control. As eloquently expressed in The Guardian, one interviewee lamented, "It's like a judgment on your masculinity… you do feel like less of a man." Yet, amidst these challenges, there emerges a new avenue of treatments that some men can take advantage of, offering renewed optimism to individuals grappling with infertility issues. Recent advancements in microbiome research have revealed the intricate role of microbial communities in human health and disease. Despite significant progress, the etiology of abnormal semen analysis (SA) parameters remains elusive in 30% of cases. This study, however, sheds light on microbial alterations associated with abnormal sperm parameters, potentially bridging gaps in understanding male factor infertility. Through meticulous analysis of semen samples using MicroGenDX NGS technologies and RTL Genomics biostatistics consulting, Osadchiy et al. identified key microbial signatures associated with abnormal sperm parameters. The study involved a cohort of men undergoing fertility evaluation or vasectomy consultation, providing comprehensive data on semen microbiota composition and sperm parameters. Key findings include: - Men with abnormally low sperm motility exhibited a higher abundance of Lactobacillus iners compared to those with normal sperm motility. - Abnormal sperm concentration was associated with increased abundance of Pseudomonas stutzeri and Pseudomonas fluorescens, while Pseudomonas putida was less abundant compared to men with normal sperm concentration. These results suggest that specific microorganisms may play critical roles in perturbations of sperm parameters, paving the way for potential therapeutic interventions to improve male fertility. Notably, Lactobacillus iners, previously studied in the context of female fertility, emerged as a significant factor in male fertility as well. MicroGenDX has plans for continued investigation into the impact of the urogenital microbiome on infertility and is conceiving new testing solutions to provide actionable results for those struggling with fertility issues. A recent Japanese study has found that treatment of microbial imbalance in women has led to an increase in fertility evidenced by success rates in pregnancy. These tests are still in development, but MicroGenDX hopes that testing those struggling with fertility and treating these imbalances will help increase fertility in both men and women. This groundbreaking research, made possible by MicroGenDX's expertise in NGS testing, contributes valuable insights to the field of male fertility and underscores the company's commitment to driving innovation in microbiome analysis. For more information about MicroGenDX and its research initiatives, please visit About MicroGenDX Founded in 2008, MicroGenDX has become the industry leader in the rapid turnaround and affordability of comprehensive Next-Generation Sequencing (NGS) and qPCR testing for clinical diagnostics. MicroGenDX is a CLIA-licensed and CAP-accredited laboratory and has been the trusted research partner for the CDC, U.S. Army, NASA, and the FDA. MicroGenDX has published over 70 clinical studies and is the most experienced molecular diagnostic laboratory, with more than 1.5 million samples processed. Contact Information: James Campagno Director of Marketing james.compgano@microgendx.com (407) 863-0043 SOURCE: MicroGenDX View the original press release on newswire.com.