Last update 08 May 2025

Hyperkeratosis Lenticularis Perstans

Basic Info

Synonyms
FLEGEL DISEASE, Flegel disease, Flegel's disease
+ [12]
Introduction
A rare skin disease characterized by usually asymptomatic, hyperkeratotic, reddish-brown papules primarily located on the lower extremities. Histological examination shows lamellar hyperkeratosis with abrupt peripheral basket-weave orthokeratosis, irregular acanthosis, and underlying lichenoid lymphocytic infiltrate. The condition may be sporadic or familial.

Analysis

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