Last update 01 Nov 2024

Persistent Polyclonal B-Cell Lymphocytosis

Last update 01 Nov 2024

Basic Info

Synonyms

PERSISTENT POLYCLONAL B-CELL LYMPHOCYTOSIS, PPBL, PPBL - persistent polyclonal B-cell lymphocytosis

+ [7]

Introduction

A rare generally benign lymphoproliferative haematological disease characterised by chronic, stable, persistent, polyclonal lymphocytosis of memory B-cell origin, the presence of binucleated lymphocytes in the peripheral blood, and a polyclonal increase in serum immunoglobulin M (IgM). Patients are most frequently asymptomatic or may present with mild splenomegaly.

Drugs associated with Persistent Polyclonal B-Cell Lymphocytosis

Clevudine

Target

HBV pol

Mechanism

HBV pol inhibitors

Active Org.

Guangxi Huibaoyuan Pharmaceutical Technology Co., Ltd. [+1]

Originator Org.

Bukwang Pharmaceutical Co., Ltd.

Active Indication

Hepatitis B [+1]

Inactive Indication

Complete atrioventricular block [+2]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date13 Jun 2001

Clinical Trials associated with Persistent Polyclonal B-Cell Lymphocytosis

NCT03296046 / CompletedNot ApplicableIIT

Epidemiologic Study of Persistent Polyclonal B-cell Lymphocytosis (PPBL) - Observatory 1990-2012

The main purpose of this study is the description of all French cases of PPBL and the establishment of minimal criteria for the pathology diagnosis and its follow-up.
The secondary objective is the immunologic and genetic characterization of lymphoid cells causing the disease.

Start Date13 Nov 2012

Sponsor / Collaborator

Centre Hospitalier Regional de Nancy

NCT00672867 / CompletedPhase 3

A Open Randomized Clinical Trial Comparing the Efficacy and Safety of Clevudine 30mg Versus Adefovir 10mg in Patients With LC-B

The purpose of this study is to compare the safety and antiviral activity of Clevudine Versus Adefovir dipivoxil in patients with LC-B.

Start Date01 Dec 2007

Sponsor / Collaborator

Bukwang Pharmaceutical Co., Ltd.

100 Clinical Results associated with Persistent Polyclonal B-Cell Lymphocytosis

100 Translational Medicine associated with Persistent Polyclonal B-Cell Lymphocytosis

0 Patents (Medical) associated with Persistent Polyclonal B-Cell Lymphocytosis

405

Literatures (Medical) associated with Persistent Polyclonal B-Cell Lymphocytosis

01 Nov 2024·Research in Veterinary Science

Screening for Japanese Black cattle herds at risk of bovine leukemia virus transmission based on the presence of persistent lymphocytosis

Article

Author: Akagami, Masataka ; Fujii, Yuki ; Hayama, Yoko ; Ouchi, Yoshinao

This study aimed to develop a screening method to identify Japanese Black (JB) cattle farms at high risk of bovine leukemia virus (BLV) transmission. We introduced a recently established lymphocyte count (LC) cut-off to detect cattle with persistent lymphocytosis (PL). To identify high-risk farms, we examined the relationship between the proportion of cattle with PL and the mean blood proviral loads (PVL) per farm. The results showed a strong correlation between the proportion of cattle with high LC, higher than the LC cut-off values for JB cattle, and the mean blood PVL per farm. This indicates that the mean blood PVL on a herd basis of JB cattle can be estimated from the proportion of cattle with high LC. Specifically, the mean blood PVL on farms with >30 % cattle having high LC was estimated to be greater than 100 copies/10 ng DNA. The higher the proportion of cattle with high LC per farm, the higher the proportion of cattle at risk as sources of BLV infection. The study demonstrated that the proportion of cattle with high LC, based on the new LC cut-off, serves as a practical index for screening high-risk farms with PL cattle that have high PVL. This finding is meaningful for prioritizing farms with a high proportion of cattle with high LC, necessitating BLV infection prevention measures, such as voluntary culling and segregation, in order to develop a regional, stepwise BLV eradication strategy.

01 Apr 2024·Transplantation and Cellular Therapy

Serial Evaluation of Preimmunization Antibody Titers in Lymphoma Patients Receiving Chimeric Antigen Receptor T Cell Therapy

Article

Author: Tosh, Pritish K ; Khurana, Arushi ; Paludo, Jonas ; Wilson, John ; Vergidis, Paschalis ; Villasboas, Jose C ; Bansal, Radhika ; Johnston, Patrick B ; Freeman, Catherine ; Bennani, N Nora ; Ansell, Stephen M ; Lin, Yi ; Wang, Yucai ; Hathcock, Matthew

Antibody titers and the potential need for immunization have not been formally studied in recipients of chimeric antigen receptor T cell therapy (CAR-T). Prior studies have shown that CD19-targeted CAR-T can induce persistent B cell aplasia but preserve plasma cells for humoral response. Aiming to assess the immune repertoire and antibody titer status of CAR-T recipients, we conducted a retrospective study of immune cell recovery and antibody titers to vaccines in anti-CD19 CAR-T recipients at Mayo Clinic, Rochester. In our cohort of 95 CAR-T recipients, almost one-half had low CD4 T and B cell counts prior to CAR-T that remained persistently low post-CAR-T. Prior to CAR-T, the seronegative rate was lowest for tetanus and highest for pneumococcus irrespective of prior transplantation status (within 2 years of CAR-T). At 3 months post-CAR-T, overall seronegativity rates were similar to pre-CAR-T rates for the prior transplantation and no prior transplantation groups. For patients who received IVIG, loss of seropositivity was seen for hepatitis A (1 of 7; 14%). No seroconversion was noted for pneumococcus. For patients who did not receive IVIG, loss of seropositivity was seen for pneumococcus (2 of 5; 40%) and hepatitis A (1 of 4; 25%). CAR-T recipients commonly experience T cell and B cell lymphopenia and might not have adequate antibody titers against vaccine-preventable diseases despite IVIG supplementation. Loss of antibody titers post-CAR-T is possible, highlighting the need for revaccination. Additional studies with long-term follow-up are needed to inform the optimal timing of immunization post-CAR-T.

01 Jan 2024·Journal of Veterinary Medical Science

Estimation of the proviral load in Japanese Black cattle infected with bovine leukemia virus by statistical modeling

Article

Author: Eitoku, Rikako ; Iino, Mei ; Koreeda, Terunori ; Iwamoto, Jiro ; Shibata, Shoichi

Enzootic bovine leukosis (EBL) is B-cell lymphoma in cattle caused by bovine leukemia virus (BLV) infection. The incidence of EBL has been increasing since 1998 in Japan, resulting in significant economic losses for farms. The BLV genome integrates with the host genome as provirus, leading to sustainably infection. Although most of the BLV-infected cattle are aleukemic, some cattle cause persistent lymphocytosis (PL) and subsequently develop EBL. Recent reports suggest the association between the risk for the transmission of BLV and the developing EBL and the proviral load (PVL) in BLV-infected cattle, which cannot measure readily in the field. This study aims to build a statistical model for predicting PVL of BLV-infected asymptomatic or PL cattle based on data accessible in the field. Five negative binomial regression models with different linear predictors were built and compared for the predictability of PVL. Consequently, the model with two explanatory variables (age in months and logarithm of lymphocyte count) was selected as the best model. The model can be used in the field as a cost-beneficial supporting tool to estimate the risk of transmission of BLV and developing EBL in infected cattle.

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Persistent Polyclonal B-Cell Lymphocytosis

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