Last update 01 Nov 2024

Adenocarcinoma of gallbladder with squamous metaplasia

Last update 01 Nov 2024

Basic Info

Synonyms

Adenocarcinoma of Gallbladder with Squamous Metaplasia, Adenocarcinoma of the Gallbladder with Squamous Metaplasia, Gallbladder Adenocarcinoma with Squamous Metaplasia

+ [9]

Introduction

An infiltrating adenocarcinoma of the gallbladder characterized by the presence of metaplastic changes of the malignant glandular cells to squamous cells.

Drugs associated with Adenocarcinoma of gallbladder with squamous metaplasia

Selumetinib sulfate

Target

MEK1 x MEK2

Mechanism

MEK1 inhibitors [+1]

Active Org.

National Cancer Institute [+11]

Originator Org.

Array BioPharma, Inc.

Active Indication

Neurofibromatoses [+53]

Inactive Indication

Acute Promyelocytic Leukemia [+65]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date10 Apr 2020

MK-2206

Target

Akt

Mechanism

Akt inhibitors

Active Org.

National Cancer Institute [+1]

Originator Org.

Merck Sharp & Dohme Corp.

Active Indication

Recurrent Prostate Carcinoma [+4]

Inactive Indication

Acute Erythroblastic Leukemia [+127]

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Adenocarcinoma of gallbladder with squamous metaplasia

NCT03909360 / Unknown statusNot ApplicableIIT

Role of Abdominal Drainage for Laparoscopic Cholecystectomy a Prospective Randomised Study

Surgeons usually choosing drainage tube for laparoscopic cholecystectomy according to their experiences but not guidelines. The investigators design a RCT to evaluate the role of drainage in LC surgery and compare the clinical results between drainage and no drainage.

Start Date14 Mar 2019

Sponsor / Collaborator

Second Affiliated Hospital Zhejiang University School of Medicine

NCT01859182 / WithdrawnPhase 2IIT

A Multicenter Phase II Study of the Combination of AZD6244 Hydrogen Sulfate and MK-2206 in Patients With Refractory Advanced Biliary Cancers

This phase II trial studies how well selumetinib and Akt inhibitor MK-2206 work in treating patients with refractory or advanced gallbladder or bile duct cancer that cannot be removed by surgery. Selumetinib and Akt inhibitor MK-2206 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Start Date01 Jan 2013

Sponsor / Collaborator

National Cancer Institute

NCT01093222 / CompletedPhase 2IIT

Phase II Study of Sorafenib (NSC-724772) and Erlotinib (NSC-718781) in Patients With Advanced Gallbladder Carcinoma or Cholangiocarcinoma

This phase II trial is studying how well giving sorafenib tosylate together with erlotinib hydrochloride works in treating patients with locally advanced, unresectable, or metastatic gallbladder cancer or cholangiocarcinoma. Sorafenib tosylate and erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor.

Start Date01 Apr 2010

Sponsor / Collaborator

National Cancer Institute

100 Clinical Results associated with Adenocarcinoma of gallbladder with squamous metaplasia

100 Translational Medicine associated with Adenocarcinoma of gallbladder with squamous metaplasia

0 Patents (Medical) associated with Adenocarcinoma of gallbladder with squamous metaplasia

281

Literatures (Medical) associated with Adenocarcinoma of gallbladder with squamous metaplasia

01 Oct 2024·BMJ Case Reports

Cholecystocolonic fistula: an incidental intraoperative discovery managed laparoscopically

Article

Author: Anand, Felix ; Selvam, Pavithra ; Thariq Ajmal, Imran ; Muralidhar, Venkiteswaran

Cholecystoenteric fistula is a rare complication of cholelithiasis, occurring in 3%–5% of patients with cholelithiasis. The symptoms are typically minimal and vague, with either acute or subacute presentations, rarely leading to bowel obstruction, and occasionally manifesting as chronic abdominal pain. In this case, a male patient in his early 30s presented with epigastric and right hypochondrial pain. On evaluation, he was diagnosed with gallstone disease and adenomyomatosis of the gallbladder. During laparoscopic cholecystectomy, a cholecystocolonic fistula was unexpectedly discovered. The fistula was managed laparoscopically using ENDOLOOP (prelooped chromic catgut ligature) ligation of the fistulous tract. The patient recovered without complications and was discharged on the third postoperative day. This case emphasises the importance of intraoperative vigilance and demonstrates a successful minimally invasive management approach.

01 Sep 2024·Radiology Case Reports

Isolated tubercular cholecystitis: A rare diagnostic challenge

Article

Author: Kumar, Shruti ; Ahuja, Sana ; Ahluwalia, Charanjeet ; Khan, Adil Aziz

Abdominal tuberculosis, particularly affecting the hepatobiliary system, presents a diagnostic challenge due to its rarity and its tendency to mimic neoplastic conditions. Tuberculosis of the gallbladder, especially in the absence of pulmonary infection, is exceedingly rare. We present a case of isolated tubercular cholecystitis in a 41-year-old female initially suspected to have neoplastic etiology. Radiological imaging revealed thickened gallbladder wall with heterogenous enhancement extending into the subcutaneous plane. Histopathological examination post-cholecystectomy confirmed tubercular etiology with epithelioid cell granulomas and focal necrosis, alongside the presence of acid-fast bacilli. Such cases pose diagnostic dilemmas due to overlapping clinical and radiological features with gallbladder carcinoma. This report emphasizes the importance of considering tuberculosis in differentials, particularly in endemic regions like India, even without pulmonary symptoms. Treatment involves postoperative administration of anti-tubercular drugs, with the preoperative diagnosis being challenging and rarely achieved due to the avoidance of invasive procedures like fine needle aspiration in suspected carcinoma cases. The rarity of isolated gallbladder tuberculosis underscores the necessity for comprehensive diagnostic evaluations and awareness among clinicians in endemic regions.

01 Apr 2023·Journal of International Medical Research

Gastric schwannoma coexisting with tubular adenoma of the gallbladder: a rare combination

Article

Author: Zhou, Chang ; Chen, Xiaodi ; Peng, Yang ; Liu, Yufei ; Cai, Meng

We report a case of a man in his early 50 s who was admitted to our hospital for anorexia. An imaging examination led to a preoperative diagnosis of a gastrointestinal stromal tumor and gallbladder stones. He underwent treatment by laparoscopic cholecystectomy and distal partial gastrectomy with lymph node dissection. The final histopathological diagnosis was gastric schwannoma and tubular adenoma of the gallbladder. Gastric schwannoma accounts for only 0.2% of all gastric tumors, and tubular adenoma constitutes only 2.2% of gallbladder tumors. This report describes the diagnosis and treatment process for this combination of tumors, thus providing a reference for similar cases.

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Adenocarcinoma of gallbladder with squamous metaplasia

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