Q1 · MEDICINE
Article
Author: Ho, Cheng-Ying ; Mobley, Bret C. ; Gordish-Dressman, Heather ; Vanden Bussche, Christopher J. ; Mason, Gary E. ; Bornhorst, Miriam ; Esbenshade, Adam J. ; Tehrani, Mahtab ; Orr, Brent A. ; LaFrance, Delecia R. ; Devaney, Joseph M. ; Meltzer, Beatrix W. ; Hofherr, Sean E. ; Burger, Peter C. ; Packer, Roger J. ; Rodriguez, Fausto J.
Among brain tumors, the BRAF (V600E) mutation is frequently associated with pleomorphic xanthoastrocytomas (PXAs) and gangliogliomas (GGs). This oncogenic mutation is also detected in ~5 % of other pediatric low-grade gliomas (LGGs) including pilocytic astrocytomas (PAs) and diffuse astrocytomas. In the current multi-institutional study of 56 non-PXA/non-GG diencephalic pediatric LGGs, the BRAF (V600) mutation rate is 36 %. V600-mutant tumors demonstrate a predilection for infants and young children (