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Last update 23 Jan 2025

Schistosomiasis Haematobia

Last update 23 Jan 2025

Basic Info

Synonyms

Bilharzia infection, Bilharzial cystitis, Bilharz住血吸虫症

+ [67]

Introduction

A human disease caused by the infection of parasitic worms SCHISTOSOMA HAEMATOBIUM. It is endemic in AFRICA and parts of the MIDDLE EAST. Tissue damages most often occur in the URINARY TRACT, specifically the URINARY BLADDER.

Drugs associated with Schistosomiasis Haematobia

Praziquantel

Target

CYP11B1

Mechanism

CYP11B1 inhibitors

Active Org.

Hunan Er-Kang Pharmaceutical Co., Ltd. [+2]

Originator Org.

Bayer AG

Active Indication

Clonorchiasis [+3]

Inactive Indication

Female genital tract infection [+3]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date29 Dec 1982

Sh28GST

Target-

Mechanism

Immunostimulants

Active Org.

Originator Org.

Active Indication

Inactive Indication

Drug Highest PhasePhase 3

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Sm-14

Target-

Mechanism

Immunostimulants

Active Org.

Orygen Biotecnologia Ltda.

Originator Org.

Orygen Biotecnologia Ltda.

Active Indication

Schistosomiasis

Inactive Indication

Schistosomiasis Haematobia [+1]

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Schistosomiasis Haematobia

ISRCTN59331501

/ RecruitingNot ApplicableIIT

Resistance Evaluation and Surveillance Initiative for Schistosomiasis Treatment

Start Date01 Nov 2024

Sponsor / Collaborator

Swiss Tropical & Public Health Institute

NCT05941884

/ Not yet recruitingNot ApplicableIIT

Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases.

Schistosomiasis is the second most common parasitic infection affecting humans, endemic in the Middle East, especially Egypt (1), and in 42 African countries (2).
There are 5 main species infecting humans: S. mansoni, S. haematobium, S. japonicum, S. intercalatum, and S. mekongi. S. haematobium is responsible for chronic urogenital infections that may cause serious complications (3). Urinary schistosomiasis is mostly borne in rural and agricultural communities, according to WHO (4)

Start Date01 Oct 2023

Sponsor / Collaborator

Assiut University

PACTR202402599048090

/ RecruitingPhase 2IIT

Efficacy and safety of pyronaridine/artesunate and pyronaridine/artesunate/praziquantel for treatment of uncomplicated Schistosoma haematobium infection in Gabonese adolescents and children

Start Date01 Sep 2023

Sponsor / Collaborator-

100 Clinical Results associated with Schistosomiasis Haematobia

100 Translational Medicine associated with Schistosomiasis Haematobia

0 Patents (Medical) associated with Schistosomiasis Haematobia

2,804

Literatures (Medical) associated with Schistosomiasis Haematobia

01 Apr 2025·International Journal of Infectious Diseases

Safety and efficacy of praziquantel in pregnant women infected with Schistosoma haematobium

Letter

Author: Okwu, Dearie Glory ; Amoako, Yaw Ampem ; Mischlinger, Johannes ; Holtfreter, Martha ; Schleenvoigt, Benjamin T ; Bohnes, Tina

01 Jan 2025·Acta Tropica

Schistosomiasis status and health impact in preschool-aged children in hard-to-reach areas and populations of Homa Bay County, Kenya

Article

Author: Isaiah, Phyllis Munyiva ; Nyawanda, Bryan ; Oloo, Joseph Otieno ; Steinmann, Peter ; Okoyo, Collins

Pediatric schistosomiasis in hard-to-reach communities is poorly understood, hampering tailored interventions. This study investigated the prevalence, intensity, health impact, and risk factors for schistosomiasis in preschool-aged children (PSAC) residing in hard-to-reach areas and populations of Homa Bay County, Kenya. A cross-sectional study was conducted among 476 PSAC aged 2-5 years across 6 islands in Lake Victoria, Homa Bay County, Kenya. Kato-Katz and urine filtration techniques diagnosed Schistosoma mansoni and S. haematobium infections respectively. Fecal occult blood (FOB) was tested to assess morbidity, and questionnaires captured sociodemographic and household water, sanitation, and hygiene data. Logistic regression models explored risk factors. The overall prevalence of S. mansoni was 26.0 %, varying considerably between islands; Ringiti had the highest prevalence (62.1 %), while Sukru had the lowest (7.7 %). No S. haematobium infections were diagnosed. Light infections were most common (15.4 %), followed by moderate (8.5 %) and heavy infections (2.2 %). Significantly increased odds for infection were observed in children aged four (aOR = 4.4, 95 % CI: 1.7-11.2) and five years (aOR = 5.6, 95 % CI: 2.2-14.5), in girls (aOR = 2.5, 95 % CI: 1.3-4.8), and in children living in Ringiti (aOR = 6.1, 95 % CI: 1.8-15.0). We noted a strong association between S. mansoni infection and FOB (aOR= 3.3, 95 % CI: 1.6-7.0). We found a high burden of schistosomiasis among PSAC in hard-to-reach communities of Homa Bay County, emphasizing the urgent need to include them in control programs. FOB could be a promising indicator for assessing schistosomiasis-related morbidity in this age group.

01 Jan 2025·The Lancet HIV

Sex as a biological variable in HIV-1 and schistosome co-infection

Review

Author: Maganga, Jane K ; Changalucha, John M ; Downs, Jennifer A ; Pham, Khanh

The sex of people living with HIV-1 infection, schistosome infection, or both, is a fundamental determinant of their clinical outcomes and of how these two infections interact in the host. Data from longitudinal and cross-sectional human studies and animal models indicate that males with HIV-1 and schistosome co-infection excrete fewer schistosome eggs and might have higher HIV-1 RNA viral loads and greater liver damage. Females with schistosome infection appear to have higher risk of HIV-1 acquisition than females without, particularly in Schistosoma haematobium infection, and a greater risk of death in HIV-1 and schistosome co-infection. Greater transmission of HIV-1 to partners has been shown in both sexes in those with schistosome infection. Biological sex is a consequential factor affecting pathophysiological and clinical responses in HIV-1 and schistosome co-infection. Designing future analyses to incorporate sex is vital to optimise research and care for people living with HIV-1, schistosomes, and HIV-1 and schistosome co-infection.

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