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Last update 23 Jan 2025

Meige Syndrome

Last update 23 Jan 2025

Basic Info

Synonyms

Blepharospasm - oromandibular dystonia, Blepharospasm Oromandibular Dyskinesia, Blepharospasm Oromandibular Dystonia

+ [46]

Introduction

A syndrome characterized by orofacial DYSTONIA; including BLEPHAROSPASM; forceful jaw opening; lip retraction; platysma muscle spasm; and tongue protrusion. It primarily affects older adults, with an incidence peak in the seventh decade of life. (From Adams et al., Principles of Neurology, 6th ed, p108)

Drugs associated with Meige Syndrome

AbobotulinumtoxinA (Ipsen Biopharm Ltd)

Target

SNAP25

Mechanism

SNAP25 inhibitors

Active Org.

Ipsen SA [+2]

Originator Org.

Ipsen Biopharm Ltd.

Active Indication

Facial Dermatoses [+7]

Inactive Indication

Low Back Pain [+9]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date28 Jan 2009

Clinical Trials associated with Meige Syndrome

NCT06292559

/ RecruitingNot ApplicableIIT

A Randomized Prospective Study Between STN-DBS and GPi-DBS in Meige Syndrome

Deep-brain stimulation (DBS) is an effective treatment for patients with Meige syndrome. The globus pallidus interna (GPi) and the subthalamic nucleus (STN) are both accepted targets for this treatment. Researchers designed this study to compare the 12-month outcomes for patients who undergo bilateral stimulation of the GPi or STN.

Start Date30 Nov 2023

Sponsor / Collaborator

Qilu Hospital of Shandong University

ChiCTR2400093942

/ RecruitingNot ApplicableIIT

A prospective study on the efficacy and safety of STN-DBS compared to GPi-DBS in the treatment of Meige syndrome

Start Date07 Oct 2023

Sponsor / Collaborator

China-Japan Friendship Hospital

ChiCTR2000033481

/ SuspendedEarly Phase 1IIT

Evaluating the safety and technical effectiveness of bilateral facial and trigeminal nerve combing for the treatment of Meige's syndrome: a first-in-human multiple center clinical trial in China

Start Date01 Jul 2020

Sponsor / Collaborator-

100 Clinical Results associated with Meige Syndrome

100 Translational Medicine associated with Meige Syndrome

0 Patents (Medical) associated with Meige Syndrome

435

Literatures (Medical) associated with Meige Syndrome

01 Jan 2025·Neurological Sciences

Deep brain stimulation and pallidotomy in primary Meige syndrome: a prospective cohort study

Article

Author: Tan, Yao ; Ding, Hu ; Liu, Zhi ; Hao, Qing-Pei ; Qin, Guang-Biao ; Liu, Ru-En ; Liu, Ye-Zu ; Zhang, Zi-Hao ; Zheng, Wen-Tao

BACKGROUNDPrimary Meige syndrome (PMS) is a rare form of dystonia, and comparative analysis of globus pallidus internal deep brain stimulation (GPi-DBS), subthalamic nucleus deep brain stimulation (STN-DBS), and pallidotomy has been lacking. This study aims to compare the efficacy, safety, and psychiatric features of GPi-DBS, STN-DBS, and pallidotomy in patients with PMS.METHODSThis prospective cohort study was divided into three groups: GPi-DBS, STN-DBS, and pallidotomy. Clinical assessments, including motor and non-motor domains, were evaluated at baseline and at 1 year and 3 years after neurostimulation/surgery.RESULTSNinety-eight patients were recruited: 46 patients received GPi-DBS, 34 received STN-DBS, and 18 underwent pallidotomy. In the GPi-DBS group, the movement score of the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) improved from a mean (SE) of 13.8 (1.0) before surgery to 5.0 (0.7) (95% CI, -10.5 to -7.1; P < 0.001) at 3 years. Similarly, in the STN-DBS group, the mean (SE) score improved from 13.2 (0.8) to 3.5 (0.5) (95% CI, -10.3 to -8.1; P < 0.001) at 3 years, and in the pallidotomy group, it improved from 14.9 (1.3) to 6.0 (1.1) (95% CI, -11.3 to -6.5; P < 0.001) at 3 years. They were comparable therapeutic approaches for PMS that can improve motor function and quality of life without non-motor side effects.CONCLUSIONSDBS and pallidotomy are safe and effective treatments for PMS, and an in-depth exploration of non-motor symptoms may be a new entry point for gaining a comprehensive understanding of the pathophysiology.

01 Jan 2025·Asian Journal of Surgery

CT-guided facial nerve radiofrequency via unilateral stylomastoid Foramen to relieve unilateral facial expressive muscle spasms for a patient with Miege's syndrome

Letter

Author: Wang, Chunxiao ; Huang, Bing ; Li, Xue ; Huang, Hao

01 Jan 2025·Asian Journal of Surgery

Computed tomography-navigated radiofrequency ablation for Meige's syndrome: A game-changer in treatment

Article

Author: Du, Xindan ; Zhao, Xian ; Yao, Ming ; Ma, Ying ; Lin, Huidan ; Huang, Bing ; Li, Xue ; Zhou, Qinghe ; Huang, Hao

BACKGROUNDMeige's syndrome severely impacts quality of life. Current treatments struggle to balance cost, risk, and effectiveness.METHODSPatients with blepharospasm were treated with facial nerves partial radiofrequency ablation guided by CT. Treatment efficacy, complications, and recurrences were evaluated during follow-up.RESULTS116 facial nerves in 58 patients with Meige's syndrome were treated using CT guidance. The average temperature at the end of radiofrequency treatment was 77.93 ± 9.8 °C, and the procedure lasted an average of 30.79 ± 7.69 min. Spasms stopped after treatment, but mild facial paralysis remained. Follow-ups ranging from 12 to 57 months showed that facial paralysis improved in an average of 3.12 ± 0.94 months. Nine patients had unilateral recurrence within 6-13 months, and three had bilateral recurrence at 14, 18, and 22 months.CONCLUSIONSPartial radiofrequency ablation of the facial nerve through percutaneous access to the bilateral stylomastoid foramen using CT navigation is an effective, safe, promising treatment for blepharospasm in Meige's syndrome patients.

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Meige Syndrome

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