Last update 01 Nov 2024

Dens in Dente

Last update 01 Nov 2024

Basic Info

Synonyms

Dens in Dente, Dens in Dentes, Dens in dente

+ [21]

Introduction

Anomaly of the tooth, found chiefly in upper lateral incisors. It is characterized by invagination of the enamel at the incisal edge.

Drugs associated with Dens in Dente

Hydronidone

Target

TGF-β

Mechanism

TGF-β inhibitors [+1]

Active Org.

GNI Group Ltd. [+1]

Originator Org.

Shanghai Genomics, Inc.

Active Indication

Hepatitis B, Chronic [+3]

Inactive Indication

Chronic viral hepatitis [+1]

Drug Highest PhasePhase 3

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Dens in Dente

NCT05414019 / Enrolling by invitationNot ApplicableIIT

Evaluation of Root Resorption Following Different Mandibular Incisors Intrusive Mechanics : A Randomized Clinical Trial

Evaluation of root resorption following different mandibular incisors intrusive mechanics : A randomized clinical trial

Start Date15 Mar 2024

Sponsor / Collaborator

Al-Azhar University

NCT04139174 / Unknown statusNot ApplicableIIT

Assessment of Root Parallelism Following Orthodontic Treatment in Adolescent vs Adult Patients Treated With Maxillary First Premolar Extraction: Observational -Analytical Study

Panoramic radiographs of finished orthodontic cases will be collected after fulfilling the inclusion and exclusion criteria. Then the collected data will be divided into two groups according to age either adolescent (12-18 years old) or adult group (after 18 years old).
in the panoramic views the long axes of canines and second premolar will be traced digitally using Digital softwares (microDicom vierwer Simeo Antonov Stoykov 0.7.7) & (IC Measure 2.0.0.161).
The objective of this study is to assess the root parallelism between maxillary canines and second premolars in adolescents versus adults group of patients requiring maxillary first premolar extraction during the orthodontic treatment.

Start Date01 Nov 2019

Sponsor / Collaborator

Cairo University

NCT04162821 / CompletedPhase 1

Clinical Pharmacokinetics of Hydroxynitone Capsules in Healthy Chinese Subjects

To evaluate the pharmacokinetic characteristics of hydronidone capsules (specification: 30 mg/ pill) in healthy subjects And the effect of feeding on pharmacokinetics to provide evidence for phase II/III clinical trial protocols.

Start Date30 Oct 2019

Sponsor / Collaborator

Beijing Kangdini Pharmaceutical Co., Ltd.

100 Clinical Results associated with Dens in Dente

100 Translational Medicine associated with Dens in Dente

0 Patents (Medical) associated with Dens in Dente

345

Literatures (Medical) associated with Dens in Dente

01 Oct 2024·Oral Radiology

Correction: Radiologic evaluation of associated symptoms and fractal analysis of unilateral dens invaginatus cases

Author: Koc, Alaettin ; Kaya, Sema

01 Oct 2024·Journal of Endodontics

Dens invaginatus Type II in an Immature Lateral Incisor With Apical Periodontitis Treated With Regenerative and Strategic Antimicrobial Procedures: A Case Report

Article

Author: Martin, Gabriela ; Siqueira, José F ; Cires, Florencia ; Alberdi, Jorge ; Bonnin, Claudia ; Rourera, Cecilia I ; Rôças, Isabela N

Dens invaginatus is a developmental dental anomaly that can predispose the tooth to pulp and periradicular disease. Management of this condition can be challenging because of anatomic and microbiologic issues. This case report describes the regenerative endodontic treatment using a strategic antimicrobial protocol for management of an immature maxillary lateral incisor with type-II dens invaginatus associated with apical periodontitis in a 13-year-old patient. The tooth presented with a complex anatomy and was associated with an active sinus tract. Because the true root canal was not negotiable in its coronal part due to the presence of the dens invaginatus, the closed end of the invagination (pseudocanal) was perforated to permit access to the apical segment of the true root canal for cleaning and disinfection. Both the invagination and the true canal were treated using an antimicrobial regimen based on chemomechanical preparation with sodium hypochlorite irrigation, supplementary disinfection with passive ultrasonic irrigation and interappointment calcium hydroxide medication. After 2 exchanges of calcium hydroxide medication, the sinus tract did not disappear, then the antimicrobial protocol was changed to include an antibiotic solution for irrigation and antibiotic paste for intracanal medication. After signs and symptoms disappeared, regenerative endodontic treatment was performed by inducing blood clot formation within the root canal. The coronal canal segment including the invagination was filled with Biodentine. Follow-up including cone-beam computed tomography examination showed complete healing of the apical periodontitis lesion and mineralized tissue formation at the apical portion of the true root canal.

01 Oct 2024·Oral Radiology

Radiologic evaluation of associated symptoms and fractal analysis of unilateral dens invaginatus cases

Article

Author: Koc, Alaettin ; Kaya, Sema

OBJECTIVEThe aim of this study is to determine the age-based prevalence of dens invaginatus cases and to learn the radiologic findings. In addition, fractal analysis of the periapical regions of unilateral dens invaginatus cases and contralateral teeth was performed to determine the effect of possible microleakage on fractal dimension.METHODSA total of 136 patients (170 teeth) identified in panoramic radiographs taken for diagnostic purposes between January 2018 and December 2023 at our Department of Oral and Maxillofacial Radiology were included in the study. Data were analysed using IBM SPSS V23. The Chi-square test was used for comparing categorical variables between groups. The relationship between the FD values calculated around the apexes of the teeth with unilateral dens invaginatus and the contralateral teeth was analyzed by paired t test. A significance level of p < 0.050 was adopted.RESULTSThe mean age of the cases was calculated as 28.1 (8-63) years. 66 (48.5%) of the cases were female, and 70 (51.1%) were male. The lateral incisor was the most affected tooth among these cases. Bilateral cases were observed in 34 patients. Type 2 was detected in 93 patients, Type 1 in 35 patients, and Type 3 dens invagination in 8 patients. Dens invaginatus cases were observed in 134 maxillary and 2 mandibular teeth. Periapical lesions were seen in 22 of these cases.CONCLUSIONSDens invaginatus cases are a congenital anomaly encountered at any age. Early diagnosis is crucial to prevent the loss of pulp vitality due to these invaginations. It should be noted that these invaginations can affect both jaws. However, due to the prevalence of occurrence in the maxillary anterior teeth and asymptomatic nonvitality, particular attention should be paid to evaluating this region.

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