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Last update 08 May 2025

Paragonimiasis

Last update 08 May 2025

Basic Info

Synonyms

DISTOMIASIS, PULMONARY, Endemic haemoptysis, Endemic hemoptysis

+ [47]

Introduction

Infection with TREMATODA of the genus PARAGONIMUS.

Drugs associated with Paragonimiasis

Praziquantel

Target

CYP11B1

Mechanism

CYP11B1 inhibitors

Active Org.

Hunan Er-Kang Pharmaceutical Co., Ltd. [+1]

Originator Org.

Bayer AG

Active Indication

Clonorchiasis [+2]

Inactive Indication

Genital Diseases, Female [+4]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

United States

First Approval Date29 Dec 1982

Clinical Trials associated with Paragonimiasis

NCT06278181

/ RecruitingNot ApplicableIIT

Risk of Malaria and Other Parasitic Infections in Individuals With Type 2 Diabetes With or Without Metabolic Syndrome in Cameroon.

Non-communicable diseases (NCDs) such as diabetes are increasing in countries where malaria transmission is common. This study aims to investigate the relationship between NCDs and parasitic infections in Cameroon. The investigators will assess the risk of malaria, as well as other parasitic diseases, in a prospectively followed group of adults with diabetes, compared with those without diabetes. Malaria parasites and intestinal worms will be tested using blood and stool collected at four time points during a one-year follow-up. In addition, this project will investigate how natural protection against malaria is affected by diabetes and other risk factors for heart diseases.

Start Date21 Sep 2023

Sponsor / Collaborator

Karolinska Institutet

[+2]

100 Clinical Results associated with Paragonimiasis

100 Translational Medicine associated with Paragonimiasis

0 Patents (Medical) associated with Paragonimiasis

888

Literatures (Medical) associated with Paragonimiasis

01 Oct 2025·Parasitology International

Diagnostic potentials of whole and fragmented major egg protein for human schistosomiasis

Article

Author: Goto, Yasuyuki ; Angeles, Jose Ma M ; Rivera, Pilarita T ; Dang-Trinh, Minh-Anh ; Kawazu, Shin-Ichiro ; Villacorte, Elena A

Heat shock proteins are known to be antigenic due to their high conservation. A 40 kDa heat shock protein, considered a major egg protein, was identified as a potential candidate antigen for diagnosing schistosomiasis. Consequently, this study aims to evaluate the diagnostic potential of SjMEP-40 for detecting human schistosomiasis. SjMEP-40 was fragmented into three distinct portions-SjMEP-40 N (N-terminal), SjMEP-40 M (middle), and SjMEP-40C (C-terminal)-to determine which segment provides the best diagnostic performance compared to the whole antigen (SjMEP-40 W) for both IgG and IgM detection. Enzyme-linked immunosorbent assay (ELISA) was used to analyze archived samples from various endemic areas in the Philippines, all previously confirmed either positive or negative for Schistosoma japonicum infection through microscopy or stool PCR. Additionally, cross-reactivity tests were conducted with other parasitic infections, including paragonimiasis, clonorchiasis, and opisthorchiasis. IgG ELISA results revealed that SjMEP-40 M has the sensitivity (82.24 %) and specificity (95.97 %). On the other hand, SjMEP-40 N showed the highest sensitivity (85.5 %) and positivity rates in IgM ELISA with both microscopy and PCR-positive samples. Overall, SjMEP-40 M showed the best diagnostic results for IgG evaluation, whereas SjMEP-40 N is the fragment responsible for antigen detection at the early stage of the disease, as shown by the IgM ELISA results. The fragmented antigens might be useful in differentiating early and chronic disease.

01 Mar 2025·Respirology Case Reports

Spontaneous Pneumothorax Secondary to Pulmonary Paragonimiasis: A Case Report Highlighting Diagnostic Delay in Eastern Nepal

Article

Author: Rupak, K. C. ; Sah, Sandip Kumar ; Adhikari, Bigyan ; Pokhrel, Ashit ; Mahato, Arun Kumar ; Shah, Sonu

ABSTRACTParagonimiasis, or oriental lung fluke, a zoonotic disease acquired by consuming raw or undercooked crustaceans such as crabs or snails, can mimic tuberculosis in endemic regions. There is a wide range of clinical symptoms depending on the parasite location, from non‐specific symptoms like diarrhoea, abdominal pain, rash, and fever to pleuropulmonary symptoms like cough, haemoptysis, chest pain, and dyspnoea. Pneumothorax is the rare clinical picture. We present a case of a 48‐year‐old male non‐smoker with a persistent cough for 3 months and who was treated for acute eosinophilic pneumonia initially at another centre. He then presented with symptoms of spontaneous pneumothorax at our centre and was treated with a chest tube. Revisiting the history, raw snail consumption was noted. Microscopic examination of a wet mount bronchoalveolar lavage (BAL) confirmed the diagnosis of Paragonimus westermani, and praziquantel was started; he improved significantly within 48 h.

01 Mar 2025·Infection, Genetics and Evolution

Considerable genetic diversity within Paragonimus heterotremus in Luang Prabang, northern Lao People's Democratic Republic

Article

Author: Maleewong, Wanchai ; Sanpool, Oranuch ; Nonthapa, Alongkorn ; Laymanivong, Sakhone ; Sadaow, Lakkhana ; Intapan, Pewpan M ; Boonroumkaew, Patcharaporn ; Banouvong, Virasack ; Rodpai, Rutchanee ; Blair, David ; Thanchomnang, Tongjit

Paragonimiasis, caused by infection with lung flukes of the genus Paragonimus, remains a significant public health concern in Southeast Asia. In Lao People's Democratic Republic (Lao PDR), information on the distribution and genetic diversity of Paragonimus species is limited. This study investigated Paragonimus metacercariae in freshwater (mountain) crabs and analyzed their genetic diversity and phylogenetic relationships. Thirty-six crabs (Indochinamon sp.) were received from Xiang Ngeun and Pak Ou in Luang Prabang Province, northern Lao PDR. Partial mitochondrial 16S rRNA sequences obtained from four crabs indicated a moderately close relationship with Indochinamon ou. A total of 81 metacercariae identified morphologically as Paragonimus heterotremus were found among 13 out of the 32 crabs dissected (40.6 %). Molecular analyses targeting the ribosomal ITS2 region and mitochondrial cytochrome c oxidase subunit 1 (cox1) gene were conducted on these metacercariae. Phylogenetic analyses revealed that P. heterotremus sequences from Lao PDR clustered with those from neighboring countries-China, Myanmar, Vietnam and Thailand-suggesting potential genetic connectivity among eastern Asian populations. Haplotype-network analysis demonstrated significant genetic diversity within P. heterotremus populations from Lao PDR, separating into two distinct haplotype groups, one of which was unique to this study. This is the first report that Indochinamon sp. crabs serve as key intermediate host for a member of the P. heterotremus complex in Luang Prabang Province and highlights the parasite's genetic diversity in this region.

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Paragonimiasis

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