Last update 01 Nov 2024

Lacrimal Duct Obstruction

Last update 01 Nov 2024

Basic Info

Synonyms

Blocked lacrimal canaliculus, Blocked tear duct, Canalicular obstruction

+ [55]

Introduction

Interference with the secretion of tears by the lacrimal glands. Obstruction of the LACRIMAL SAC or NASOLACRIMAL DUCT causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)

Drugs associated with Lacrimal Duct Obstruction

Besifloxacin Hydrochloride

Target

Bacterial DNA gyrase x Top II x Topoisomerase IV

Mechanism

Bacterial DNA gyrase inhibitors [+2]

Active Org.

Bausch & Lomb, Inc.

Originator Org.

Bausch & Lomb, Inc.

Active Indication

Conjunctivitis, Bacterial

Inactive Indication

acute bacterial conjunctivitis [+3]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date28 May 2009

Sodium Pertechnetate (99mTc)

Target-

Mechanism

SPECT

Active Org.

Curium US Holdings LLC [+4]

Originator Org.

PDRadiopharma, Inc.

Active Indication

Neoplasms [+8]

Inactive Indication

Vesico-Ureteral Reflux

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date23 Feb 1973

106

Clinical Trials associated with Lacrimal Duct Obstruction

ChiCTR2400084579 / SuspendedNot ApplicableIIT

A study on the correlation between differential expression of tear cytokines and the degree of tear sac fibrosis in patients with primary nasolacrimal duct obstruction

Start Date27 May 2024

Sponsor / Collaborator-

NCT06346561 / RecruitingNot ApplicableIIT

The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study

The most important symptoms of nasolacrimal duct obstruction are excessive tearing and mucoid discharge.
The proposed treatment in this regard is dacryocystorhinostomy (DCR) surgery. Therefore, hemostasis is of great significance in performing DCR surgery. In this regard, the reduction of controlled hypotension and the control of hemodynamic responses of the body to stress effectively reduce the bleeding volume during surgery.
Hence, there is no enough studies about controlled hypotension in DCR we decided to perform such a comparison between the effect of dexmedetomidine and labetalol in providing controlled hypotension during DCR surgery.

Start Date30 Mar 2024

Sponsor / Collaborator

Sohag University

NCT06226181 / RecruitingPhase 1IIT

Amniotic Membrane for External Dacryocystorhinostomy and Comparison of Success Rate With Conventional Surgery for Patients With Nasolacrimal Duct Obstruction

This study aims to compare the success rate of external dacryocystorhinostomy with and without amniotic membranes in patients with nasolacrimal duct obstruction.

Start Date01 Jan 2024

Sponsor / Collaborator-

100 Clinical Results associated with Lacrimal Duct Obstruction

100 Translational Medicine associated with Lacrimal Duct Obstruction

0 Patents (Medical) associated with Lacrimal Duct Obstruction

3,056

Literatures (Medical) associated with Lacrimal Duct Obstruction

01 Dec 2024·American Journal of Ophthalmology Case Reports

Pediatric dacryolith masquerading as congenital nasolacrimal duct obstruction

Article

Author: Ranjan, Ashish ; Ali, Mohammad Javed ; Pokal, Upasana

PurposeTo report a rare case of a pediatric dacryolith masquerading as congenital nasolacrimal duct obstruction (CNLDO).ObservationsA two-year-old male child presented with history of intermittent epiphora and discharge since the age of six months. Clinical evaluation demonstrated raised tear meniscus height and delayed fluorescein dye disappearance test in the right eye. Lacrimal irrigation of the right eye under general anesthesia demonstrated 90 % regurgitation (subjectively) of mucoid fluid with a hard stop. Nasal endoscopy examination demonstrated a dacryolith obstructing the opening of the nasolacrimal duct (NLD) in the inferior meatus. The dacryolith was teased out of the NLD and following its removal the lacrimal irrigation was freely patent. At six-months post operative follow up, epiphora resolved and the child was asymptomatic.Conclusions and importanceWhile cases of canaliculitis is uncommon in pediatric age group, it is rare to find a NLD dacryolith in a toddler. To the best of the authors' knowledge, there are few prior reports on pediatric NLD dacryolith masquerading as CNLDO in a toddler (1-3 years).

01 Dec 2024·American Journal of Ophthalmology Case Reports

Pediatric dacryolith masquerading as congenital nasolacrimal duct obstruction

Article

Author: Ranjan, Ashish ; Ali, Mohammad Javed ; Pokal, Upasana

01 Nov 2024·Indian journal of ophthalmology

Comparative study of the direct closure of surgical incision for external dacryocystorhinostomy using 6-0 Prolene versus Dermabond ®.

Article

Author: Peris-Martínez, Cristina ; Ortega-Evangelio, Leticia

PURPOSEIn this study, we aimed to compare closure of the incision for external dacryocystorhinostomy (ext-DCR) by suturing with 6-0 Prolene versus closure with 2-octyl cyanoacrylate and assess the results in terms of the aesthetic and functional aspects of the scar, operating time, postoperative symptoms and complications, and the economic cost of the two techniques.METHODSSixty-three patients with distal lacrimal obstruction and indication of ext-DCR were initially enrolled in a longitudinal prospective cohort study. Patients underwent ophthalmologic evaluations including lacrimal probing, external examination with photograph, measurement of the surgical wound, timing the cutaneous closure phase of the surgery, recording postoperative wound pain using visual analog scale (VAS), and recording the patient's and clinician's subjective satisfaction with the scar using Patient and Observer Scar Assessment Scale (POSAS) at 6 months postsurgery. The 63 eyes were divided into two groups: the wounds in group 1 were closed with 6-0 Prolene using continuous locking suture and the wounds in group 2 were closed with 2-octyl cyanoacrylate.RESULTSThere was no difference in baseline characteristics (age, sex, and race), and no statistically significant differences were found in wound length, POSAS score, VAS score, or serious complications of the wound between the two groups. There were differences in surgery time and economic cost for group 2 compared to group 1 of -2.39 min and -€5.37/operation, respectively.CONCLUSIONThis is the first study in the literature that compares 6-0 Prolene versus Dermabond ® . The latter one presents advantages compared to Prolene, given that it reduces the length of surgery, reduces costs, and allows for greater flexibility in postoperative follow-up visits.

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