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Last update 08 May 2025

Hairy Leukoplakia

Last update 08 May 2025

Basic Info

Synonyms

Hairy Leukoplakia, Hairy Leukoplakia of Mouth, Hairy Leukoplakia of Oral Mucosa

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Introduction

Epithelial hyperplasia of the oral mucosa associated with Epstein-Barr virus (HERPESVIRUS 4, HUMAN) and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy.

Clinical Trials associated with Hairy Leukoplakia

NCT00002026

/ CompletedNot Applicable

Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV)

To evaluate the efficacy of oral acyclovir for the treatment and suppression of Epstein-Barr virus (EBV) related hairy leukoplakia (HL). To determine the long-term safety of acyclovir in the AIDS-related complex (ARC) patient with HL. To monitor the progression of HIV disease in the HL patient and compare to existing historical control data.

Start Date-

Sponsor / Collaborator

Glaxo Wellcome SA

DRKS00006208

/ RecruitingNot ApplicableIIT

Epidemiological cross-sectional study on the impact of malocclusion and habits on oral health and quality of life

Start Date01 Mar 2017

Sponsor / Collaborator-

100 Clinical Results associated with Hairy Leukoplakia

100 Translational Medicine associated with Hairy Leukoplakia

0 Patents (Medical) associated with Hairy Leukoplakia

802

Literatures (Medical) associated with Hairy Leukoplakia

01 Jan 2025·Journal of Clinical and Experimental Dentistry

A rare case of hairy leukoplakia in a young immunocompetent patient

Article

Author: Moura, Ludimila Lemes ; Santos, Paulo Sérgio da Silva ; Carrapato, Victor Villatoro ; Santos, Marcia Mirolde Magno de Carvalho

We present a case of oral hairy leukoplakia (OHL) in a male, 21-year-old immunocompetent patient. The patient had white, asymptomatic plaques located bilaterally on the tongue margin. The patient noticed the signs days after burning his tongue with hot food, which triggered the investigation. The case was treated initially as candidiasis and frictional keratosis. Exfoliative cytology indicated the presence of actinomycetes in the lesions, and a blood count suggested mild leukopenia (3,910/mm³; reference value 4,500 - 11,000/mm³). Photodynamic therapy and antiseptic mouthwash were used, with no improvement in the condition. The diagnosis of OHL had concluded after an incisional biopsy and immunohistochemical examination for anti-EBV. The patient's blood and serological tests showed no noteworthy changes. Cases of hairy leukoplakia in immunocompetent patients had founded in the literature and suggest that when this occurs, patients often have some comorbidity, such as hypertension, or use medications such as antihypertensives and steroid inhalers. However, the patient in the present case did not any of these conditions, which made the diagnosis challenging. In any case, it is always important to investigate the medical history and immune status of a patient diagnosed with OHL. Key words:Oral hairy leukoplakia, Epstein-Barr virus, Immunocompetent.

19 Dec 2024·New England Journal of Medicine

Oral Hairy Leukoplakia

Article

Author: Schauer, Franziska ; Karakioulaki, Meropi

01 Nov 2024·American family physician

Common Tongue Conditions in Primary Care.

Review

Author: Schettini, Priscille ; Straub, Liza ; Myrex, Palee

Tongue conditions occur in 15.5% of the US population. The most common tongue conditions are geographic tongue, fissured tongue, and black hairy tongue; these conditions do not require treatment. Median rhomboid glossitis can be associated with a candidal infection; symptomatic lesions usually improve with use of antifungals. Atrophic glossitis is often linked to a nutritional deficiency and resolves with treatment of the underlying condition. Oral hairy leukoplakia is caused by Epstein-Barr virus and most often presents in patients with severely compromised immunity; it can be treated with oral antivirals. Growths of the tongue usually require biopsy to differentiate benign lesions (eg, traumatic fibromas, squamous cell papillomas) from leukoplakia and squamous cell carcinoma. Referral to an oral and maxillofacial surgeon, otolaryngologist, or a dentist experienced in oral pathology may be indicated. Burning mouth syndrome often involves the tongue, and if it does not resolve spontaneously, studies have shown improvement with gabapentin, topical clonazepam, capsaicin, and cognitive behavior therapy. Oral lichen planus is a chronic inflammatory disorder that can affect the tongue and is best treated with topical or systemic corticosteroids and calcineurin inhibitors. There is a lack of consensus on the definition and treatment of ankyloglossia (tongue-tie); however, some evidence supports that frenotomy can improve breastfeeding and decrease lactation-associated nipple pain.

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