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Last update 20 Mar 2025

Fentiazac

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

4-(4-Chlorophenyl)-2-phenyl-5-thiazoleacetic acid, 4-(p-Chlorophenyl)-2-phenyl-5-thiazoleacetic acid, Fentiazac (JAN/USAN/INN)

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Target-

Action-

Mechanism-

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication

InflammationPain

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC17H12ClNO2S

InChIKeyJIEKMACRVQTPRC-UHFFFAOYSA-N

CAS Registry18046-21-4

100 Clinical Results associated with Fentiazac

100 Translational Medicine associated with Fentiazac

100 Patents (Medical) associated with Fentiazac

173

Literatures (Medical) associated with Fentiazac

23 Jan 2025·Nature

Photochemical permutation of thiazoles, isothiazoles and other azoles

Article

Author: Dos Santos, Thiago ; Yildiz, Dilara Berna ; Buettner, Cornelia S ; Ruffoni, Alessandro ; Xu, Yan ; Derdau, Volker ; Buettner, Cornelia S. ; Bossart, Martin ; Lonardi, Giovanni ; Alonso, Maialen ; Roure, Baptiste ; Leonori, Daniele ; Méndez, María ; dos Santos, Thiago ; Llaveria, Josep

Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery^1,2. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given target can pose considerable difficulties or even thwart the preparation of specific derivatives for further study^3,4. Here we report a conceptually different approach in which photochemical irradiation can be used to alter the structure of thiazoles and isothiazoles in a selective and predictable manner. On photoexcitation, these derivatives populate their π,π* singlet excited states that undergo a series of structural rearrangements, leading to an overall permutation of the cyclic system and its substituents. This means that once the initial heteroaromatic scaffold has been prepared, it can then function as an entry point to access other molecules by selective structural permutation. This approach operates under mild photochemical conditions that tolerate many chemically distinct functionalities. Preliminary findings also show the potential for extending this method to other azole systems, including benzo[d]isothiazole, indazole, pyrazole and isoxazole. This strategy establishes photochemical permutation as a powerful and convenient method for the preparation of complex and difficult-to-access derivatives from more available structural isomers.

16 Jul 2021·Chemistry – A European Journal

“Snapshot” Trapping of Multiple Transient Azolyllithiums in Batch

Article

Author: Okano, Kentaro ; Feng, Yuxuan ; Mori, Atsunori ; Inoue, Kengo

AbstractRecent developments in flow microreactor technology have allowed the use of transient organolithium compounds that cannot be realized in a batch reactor. However, trapping the transient aryllithiums in a “halogen dance” is still challenging. Herein is reported the trapping of such short‐lived azolyllithiums in a batch reactor by developing a finely tuned in situ zincation using zinc halide diamine complexes. The reaction rate is controlled by the appropriate choice of diamine ligand. The reaction is operationally simple and can be performed at 0 °C with high reproducibility on a multigram scale. This method was applicable to a wide range of brominated azoles allowing deprotonative functionalization, which was used for the concise divergent syntheses of both constitutional isomers of biologically active azoles.

20 Nov 2020·Current Topics in Medicinal ChemistryQ4 · MEDICINE

2,4,5-Trisubstituted Thiazole: A Privileged Scaffold in Drug Design and Activity Improvement

Q4 · MEDICINE

Review

Author: Shu, Bing ; Zhang, Yaodong ; Deora, Girdhar Singh ; Li, Qing-Shan ; Zhang, Zhen

Thiazole is an important 5-membered heterocyclic compound containing nitrogen and sulfur atoms with various pharmaceutical applications including anti-inflammatory, anti-cancer, anti-viral, hypoglycemic, anti-bacterial and anti-fungal activities. Until now, the FDA-approved drugs containing thiazole moiety have achieved great success such as dasatinib and dabrafenib. In recent years, considerable research has been focused on thiazole derivatives, especially 2,4,5-trisubstituted thiazole derivatives, due to their multiple medicinal applications. This review covers related literature in the past 20 years, which reported the 2,4,5-trisubstituted thiazole as a privileged scaffold in drug design and activity improvement. Moreover, this review aimed to provide greater insights into the rational design of more potent pharmaceutical molecules based on 2,4,5-trisubstituted thiazole in the future.

100 Deals associated with Fentiazac

External Link

KEGG	Wiki	ATC	Drug Bank
D01975	Fentiazac	M02AA14 M01AB10	DB13217

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Inflammation	-	-	-
Pain	-	-	-

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