Delving into the Latest Updates on Human Chorionic Gonadotrophin (Fuji Pharma) with Synapse

Overview

Basic Info

Drug Type

Hormone

Synonyms-

Target

LHCGR

Mechanism

LHCGR agonists(Luteinizing hormone/Choriogonadotropin receptor agonists)

Therapeutic Areas

Congenital DisordersEndocrinology and Metabolic DiseaseUrogenital Diseases+ [1]

Active Indication

Abortion, HabitualAbortion, ThreatenedCryptorchidism+ [1]

Inactive Indication-

Originator Organization

Fuji Pharma Co., Ltd.

Active Organization

Fuji Pharma Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

JP (29 Aug 2001),

Abortion, HabitualAbortion, ThreatenedCryptorchidism+ [1]

Regulation-

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RESEARCH QUESTIONCan spermatozoa penetrate maturing metaphase I (MI) oocytes, and render subsequent development following conventional IVF in a mouse model?DESIGNICR mice were used in this study. Metaphase II (MII) cumulus-oocyte complexes (COC) harvested 15 h after injection of human chorionic gonadotrophin (HCG) were used for IVF as the control group (Group 1). In the treatment group (Group 2), maturing MI COC harvested 7 h after HCG injection were used for IVF. Fertilization, pronuclear formation, cleavage, blastocyst formation, DNA methylation status, chromosome number and live birth rates were used to evaluate the developmental dynamics and competency of maturing MI oocytes following conventional IVF.RESULTSMaturing MI COC were fertilized using conventional IVF, and sperm penetration at MI-telophase I triggered oocyte activation. Most embryos resulting from fertilized MI oocytes developed to blastocyst stage during preimplantation development, albeit a substantial proportion of them were triploids due to the absence of the second meiotic division. Some of the embryos derived from fertilization of maturing oocytes were able to implant and gave rise to full-term development.CONCLUSIONMaturing MI COC from follicles before ovulation could be used for mouse IVF, and fertilized MI oocytes had high potential for development. Healthy offspring can be generated from maturing MI COC following conventional IVF. MI COC may represent a valuable source of 'usable' biomaterial in assisted reproduction. However, many embryos derived from MI COC via IVF have abnormal chromosome numbers in the mouse model. The implications of these findings for human IVF remain to be investigated.

01 Oct 2024·Reproductive BioMedicine Online

The dark side of random-start ovarian stimulation: ovarian hyperstimulation syndrome due to inadvertent pregnancy

Article

Author: De Vos, M ; Semrl, N ; Blockeel, C

RESEARCH QUESTIONCan inadvertent pregnancies go unnoticed when initiating random-start ovarian stimulation (RSOS) despite monitoring?DESIGNCase series at a university-based tertiary care fertility clinic.RESULTSBetween June 2022 and December 2023, two cases of undetected early pregnancy at the onset of RSOS were identified, both leading to severe ovarian hyperstimulation syndrome (OHSS) with hospitalization.CONCLUSIONRSOS protocols add flexibility in fertility clinics when there is no intention of a fresh embryo transfer, but may be associated with insidious risk of OHSS. The authors advocate for comprehensive consultation and serial monitoring of human chorionic gonadotrophin during ovarian stimulation, while cautioning against over-reliance on baseline hormone concentrations when initiating RSOS. If the benefits of RSOS seem limited, healthcare providers should consider delaying ovarian stimulation to avert health, but also medicolegal and financial, complications.

01 May 2024·Reproductive BioMedicine Online

Investigation of luteal HCG supplementation in GnRH-agonist-triggered fresh embryo transfer cycles: a randomized controlled trial

Article

Author: Andersen, Claus Yding ; Humaidan, Peter ; Fedder, Jens ; Möller, Sören ; Pedersen, Dorrit Elschner ; Erb, Karin ; Svenstrup, Louise

RESEARCH QUESTIONDoes splitting the human chorionic gonadotrophin (HCG) support in IVF cycles triggered by a gonadotrophin-releasing hormone agonist result in a better progesterone profile?DESIGNRandomized controlled three-arm study, performed at the Fertility Clinic, Odense University Hospital, Denmark. Patients with 12-25 follicles ≥12 mm were randomized into three groups: Group 1 - ovulation triggered with 6500 IU HCG; Group 2 - ovulation triggered with 0.5 mg GnRH agonist, followed by 1500 IU HCG on the day of oocyte retrieval (OCR); and Group 3 - ovulation triggered with 0.5 mg GnRH agonist, followed by 1000 IU HCG on the day of OCR and 500 IU HCG on OCR + 5. All groups received 180 mg vaginal progesterone. Progesterone concentrations were analysed in eight blood samples from each patient.RESULTSSixty-nine patients completed the study. Baseline and laboratory data were comparable. Progesterone concentration peaked on OCR + 4 in Groups 1 and 2, and peaked on OCR + 6 in Group 3. On OCR + 6, the progesterone concentration in Group 2 was significantly lower compared with Groups 1 and 3 (P = 0.003 and P < 0.001, respectively). On OCR + 8, the progesterone concentration in Group 3 was significantly higher compared with the other groups (both P<0.001). Progesterone concentrations were significantly higher in Group 3 from OCR + 6 until OCR + 14 compared with the other groups (all P ≤ 0.003). Four patients developed ovarian hyperstimulation syndrome in Group 3.CONCLUSIONSequential HCG support after a GnRH agonist trigger provides a better progesterone concentration in the luteal phase.

100 Deals associated with Human Chorionic Gonadotrophin (Fuji Pharma)

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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Abortion, Habitual	JP	Fuji Pharma Co., Ltd.	29 Aug 2001
Abortion, Threatened	JP	Fuji Pharma Co., Ltd.	29 Aug 2001
Cryptorchidism	JP	Fuji Pharma Co., Ltd.	29 Aug 2001
Infertility, Male	JP	Fuji Pharma Co., Ltd.	29 Aug 2001

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ECTRIMS2019	Not Applicable	Multiple Sclerosis Human chorionic gonadotrophin (hCG)	-	urinary hCG	gtwctkoclz(wggaqroior) = coygbxkgvu rxdleyjnkc (owdagbhjpz ) View more	Positive	10 Sep 2019
				recombinant hCG	gtwctkoclz(wggaqroior) = kxbwzrltiq rxdleyjnkc (owdagbhjpz ) View more