HRS-9950

主要目的： 1. HRS9950 单次和多次给药在健康人中的安全性与耐受性； 2.食物对药代、药动学的影响； 3.多次给药在慢乙肝患者中的安全性与耐受性。 次要目的： 1.单次和多次给药的药动学； 2.食物影响对健康人的安全性与耐受性； 3.单次和多次给药的药动学。 探索性目的： 1.多次给药在慢乙型肝炎患者中的病毒学指标。

The study is a randomized, Double-Blind, Placebo-Controlled study to evaluate the safety, tolerability and pharmacokinetics, pharmacodynamics and food effect of HRS9950. The study will be conducted in three parts sequentially:
Part 1, evaluate the safety, tolerability and pharmacokinetics, pharmacodynamics of single doses and multiple dose of HRS9950 tablet in healthy subjects. Part 1 will consist of 84 healthy subjects, 8 groups.There will be 14 subjects in 0.75mg dose group,10 subjects in each other dose group .
Part 2, evaluate food effect of HRS9950 in healthy subjects. Part 2 will consist of 14 healthy subjects, 1 group (one of groups in Part 1).
Part 3, evaluate the safety, tolerability and pharmacokinetics, pharmacodynamics of multiple doses of HRS9950 tablet in naive and treatment-experienced chronic hepatitis B (CHB) patients. Part 3 will consist of 60 CHB patients, 1 group for naive patients and 5 groups for treatment-experienced patients.