Last update 20 Mar 2025

EX-101

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms
Anti-CD3/anti-HER2 bispecific T-cell engager
Target
CD3 x HER2
Action
stimulants, antagonists
Mechanism
CD3 stimulants(T cell surface glycoprotein CD3 stimulants), HER2 antagonists(Receptor protein-tyrosine kinase erbB-2 antagonists)
Therapeutic Areas
NeoplasmsDigestive System DisordersSkin and Musculoskeletal Diseases
Active Indication
Breast CancerStomach CancerHER2 Positive Solid Tumors
Inactive Indication-
Originator Organization
Excelmab, Inc.Excelmab, Inc.
Active Organization
Excelmab, Inc.Excelmab, Inc.
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with EX-101
CTR20212292
/ RecruitingPhase 1
一项开放性、剂量递增和剂量扩展评估EX101注射液治疗HER2阳性晚期实体瘤患者的I期临床研究
[Translation] An open-label, dose-escalation and dose-expansion phase I clinical study evaluating EX101 injection in patients with HER2-positive advanced solid tumors
100 Clinical Results associated with EX-101
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100 Translational Medicine associated with EX-101
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100 Patents (Medical) associated with EX-101
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100 Deals associated with EX-101
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 1
China
Excelmab, Inc.Excelmab, Inc.
30 Jan 2022
Breast CancerPhase 1
United States
Excelmab, Inc.Excelmab, Inc.
30 Jan 2022
Stomach CancerPhase 1
China
Excelmab, Inc.Excelmab, Inc.
30 Jan 2022
Stomach CancerPhase 1
United States
Excelmab, Inc.Excelmab, Inc.
30 Jan 2022
HER2 Positive Solid TumorsPhase 1
China
Excelmab, Inc.Excelmab, Inc.
16 Nov 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Translational Medicine

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Deal

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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