Last update 20 Sep 2026

VBC108

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms-
Target
CDH17 x CLDN18.2 x Top I x Tubulin
Action
antagonists, inhibitors
Mechanism
CDH17 antagonists(Cadherin-17 antagonists), CLDN18.2 inhibitors(Claudin 18.2 inhibitors), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Therapeutic Areas
NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease
Active Indication
Advanced Malignant Solid NeoplasmBiliary Tract NeoplasmsColorectal Cancer+ [3]
Inactive Indication-
Originator Organization
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
Active Organization
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,LtdVelaVigo (Hong Kong) Limited
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC39H67N5O7
InChIKeyDASWEROEPLKSEI-UIJRFTGLSA-N
CAS Registry474645-27-7
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Related

1
Clinical Trials associated with VBC108
CTR20263629
/ Not yet recruitingPhase 1/2
VBC108在晚期恶性实体肿瘤受试者中的首次人体临床试验
[Translation] First-in-human clinical trial of VBC108 in subjects with advanced malignant solid tumors
100 Clinical Results associated with VBC108
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100 Translational Medicine associated with VBC108
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100 Patents (Medical) associated with VBC108
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100 Deals associated with VBC108
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
United States
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
30 Jul 2026
Advanced Malignant Solid NeoplasmPhase 2
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
30 Jul 2026
Advanced Malignant Solid NeoplasmPhase 2
Australia
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
30 Jul 2026
Biliary Tract NeoplasmsIND Approval
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
15 Sep 2026
Colorectal CancerIND Approval
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
15 Sep 2026
Gastrooesophageal junction cancerIND Approval
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
15 Sep 2026
Pancreatic Ductal AdenocarcinomaIND Approval
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
15 Sep 2026
Stomach CancerPreclinical
Hong Kong
VelaVigo (Hong Kong) Limited
27 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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