Strain PM004 is a cultured representative of human microbial taxon 955, a bacterium from the phylum Saccharibacteria . It is an obligate parasite with a genome of <0.9 Mb and can be grown in coculture with its host, Pseudopropionibacterium propionicum . The complete genome sequence is presented here.

01 Jun 2019·Environmental Research

Wildland firefighter smoke exposure and risk of lung cancer and cardiovascular disease mortality

Article

Author: Navarro, Kathleen M ; Domitrovich, Joseph W ; Reinhardt, Timothy E ; Ottmar, Roger D ; Balmes, John R ; Kleinman, Michael T ; Broyles, George A ; Naher, Luke P ; Mackay, Chris E

Wildland firefighters are exposed to wood smoke, which contains hazardous air pollutants, by suppressing thousands of wildfires across the U. S. each year. We estimated the relative risk of lung cancer and cardiovascular disease mortality from existing PM_2.5 exposure-response relationships using measured PM₄ concentrations from smoke and breathing rates from wildland firefighter field studies across different exposure scenarios. To estimate the relative risk of lung cancer (LC) and cardiovascular disease (CVD) mortality from exposure to PM_2.5 from smoke, we used an existing exposure-response (ER) relationship. We estimated the daily dose of wildfire smoke PM_2.5 from measured concentrations of PM₄, estimated wildland firefighter breathing rates, daily shift duration (hours per day) and frequency of exposure (fire days per year and career duration). Firefighters who worked 49 days per year were exposed to a daily dose of PM₄ that ranged from 0.15 mg to 0.74 mg for a 5- and 25-year career, respectively. The daily dose for firefighters working 98 days per year of PM₄ ranged from 0.30 mg to 1.49 mg. Across all exposure scenarios (49 and 98 fire days per year) and career durations (5-25 years), we estimated that wildland firefighters were at an increased risk of LC (8 percent to 43 percent) and CVD (16 percent to 30 percent) mortality. This unique approach assessed long term health risks for wildland firefighters and demonstrated that wildland firefighters have an increased risk of lung cancer and cardiovascular disease mortality.

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Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Preclinical	GB	PhoreMost Ltd.Startup	-

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