Marine sponges have consistently been the richest source of new marine natural products with unprecedented chemical scaffolds and potent biological activities that have been reported in the chemical literature since the early 1970s. During the last 40years, chemists in the Andersen laboratory at UBC, in collaboration with biologists, have discovered many novel bioactive sponge natural products. Four experimental drug candidates for treatment of inflammation and cancer, that were inspired by members of this sponge natural product collection, have progressed to phase I/II/III clinical trials. This review recounts the scientific stories behind the discovery and development of these four drug candidates; IPL576,092, HTI-286 (Taltobulin), EPI-506 (Ralaniten acetate), and AQX-1125.

01 Jul 2013·Monatshefte für Chemie - Chemical Monthly

An improved and efficient synthesis for IPL576,092 and its analogues

Author: Rong Huang ; Jin Liu ; Hongyou Zhu

An improved and efficient preparation of IPL576,092 was developed.The synthetic route involves selective allylic oxidation of Δ⁵-sterols and subsequent hydroboration-oxidation as the key steps.In addition, two analogs were readily synthesized from com. available steroidal compounds in two steps in the same way.

01 Jan 2012·Current Pharmaceutical BiotechnologyQ4 · MEDICINE

Current Status on Natural Products with Antitumor Activity from Brazilian Marine Sponges

Q4 · MEDICINE

Review

Author: Mothes, Beatriz ; Biegelmeyer da Silva, Renata ; Moreira, Jose Claudio Fonseca ; Henriques, Amelia Teresinha ; Conte da Frota, Mario Luiz Jr.

Over the last few years, samples from the marine environment have been screened for a variety of compounds with different biological activities. Among all marine organisms, sponges represent one of the most promising sources of leads in the research of new cancer drugs. However, there are few reports on screening Brazilian marine sponges for biological activities. In the following review, the current status of natural product research relating to Brazilian marine sponges is summarized, particularly for compounds demonstrating potential antitumor activity.

100 Deals associated with HMR-4011A

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Indication	Highest Phase	Country/Location	Organization	Date
Asthma	Phase 2	-	Sanofi	-
Asthma	Phase 2	-	Inflazyme Pharmaceuticals	-
Asthma	Phase 2	United Kingdom	-	-
Dermatitis, Atopic	Phase 2	Canada	-	-
Ocular inflammation	Phase 2	Canada	-	-
Rhinitis, Allergic	Phase 2	Canada	-	-

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