Tezacitabine

Elimination of organic dyes from wastewater is very important for our safe environment and sound health. In this work, adsorptive removal of cationic dyes, especially small ones, was investigated with carbonaceous materials to develop a competitive adsorption technology. To improve the performance of metal-organic framework (MOF)-derived carbons (MDCs) in dye adsorption, an MDC, derived from a MOF (MAF-6), was oxidatively functionalized with ammonium persulfate solutions (APSs). Although the porosity of pristine MDC decreased with functionalization via oxidation, functionalized MDCs (FMDCs), especially FMDC(1.0) that was obtained via treating MDC with APS (1.0 M), showed remarkable performances in the adsorption of small cationic dyes like methylene blue (MB) and azure B. For example, FMDC(1.0) had the maximum adsorption capacity (Q_o) of 625.0 mg/g (for MB) which is larger than any reported value with carbonaceous materials. Moreover, the obtained Q_o was around 4 and 2 times that of activated carbon with Q_o of 160 mg/g and MDC with Q_o of 298 mg/g, respectively. On the contrary, oxidative treatment of MDC was negative in adsorption of an anionic dye such as methyl orange. Moreover, the functionalized MDC was not very effective in the adsorption of cationic dyes with large sizes (like brilliant green, crystal violet, Janus green B, and rhodamine B) because of the limited pore size of the studied adsorbent FMDC(1.0). The remarkable adsorption of MB over FMDC(1.0) could be explained by electrostatic and π-π interactions. Finally, the facile recyclability of the FMDC(1.0) in MB adsorption was confirmed via successive adsorptions, FT-IR, and nitrogen adsorption; therefore, FMDC(1.0) can be suggested as a potential adsorbent to remove cationic dyes, especially with small molecular sizes.

We report the structural effect of 2'‐deoxy‐2',2'‐difluorocytidine (dFdC) insertions in the DNA strand of a DNA : RNA hybrid duplex and in a self‐complementary DNA : DNA duplex. In both cases, the modification slightly destabilizes the duplex and provokes minor local distortions that are more pronounced in the case of the DNA : RNA hybrid. Analysis of the solution structures determined by NMR methods show that dFdC is an adaptable derivative that adopts North type sugar conformation when inserted in pure DNA, or a South sugar conformation in the context of DNA : RNA hybrids. In this latter context, South sugar pucker favors the formation of a 2'F⋅⋅H8 attractive interaction with a neighboring purine, which compensates the destabilizing effect of base pair distortions. These interactions share some features with pseudohydrogen bonds described previously in other nucleic acids structures with fluorine modified sugars.