The corrosion inhibition property of a hydrazone derivative, namely 2-(2-{[2-(4-pyridylcabonyl)hydrazono]methyl}phenoxy)acetic acid (PMA) for mild steel surface corrosion in synthetic seawater medium was analyzed by weight loss, electrochem. techniques (potentiodynamic polarization and electrochem. impedance).PMA is a good corrosion inhibitor and the inhibition efficiency increased with the increase of PMA concentration, while the adsorption followed the Langmuir isotherm.XPS, SEM, theor. calculation of electronic d., mol. electrostatic potential and mol. dynamics were carried out to establish mechanism of corrosion inhibition for mild steel with PMA in synthetic seawater medium.The inhibition action of the compound was assumed to occur via adsorption on the steel surface through the active centers in the mol.The corrosion inhibition is due to the formation of a chemisorbed film on the steel surface.

15 Jun 2010·Acta Crystallographica Section E Structure Reports Online

2-(2-{[2-(4-Pyridylcarbonyl)hydrazinylidene]methyl}phenoxy)acetic acid

Article

Author: Liu, Zheng ; Liu, Bao-Yu ; Xia, Jin-Hong

In the title compound, C(15)H(13)N(3)O(4), the pyridine and benzene rings are nearly perpendicular [dihedral angle = 84.24 (5)°]. In the crystal structure, classical O-H⋯N hydrogen bonding between the OH group of the carboxyl unit and a neighbouring pyridine ring N atom and N-H⋯O hydrogen bonding between the imine NH group and a neighbouring O atom of an acyl unit, together with complementary non-classical C-H⋯O hydrogen bonds between carboxyl O atoms and neighbouring CH groups, link the mol-ecules into a three-dimensional system.

01 Oct 1996·Risk AnalysisQ2 · MEDICINE

A Semiparametric Approach to Risk Assessment for Quantitative Outcomes

Q2 · MEDICINE

Article

Author: Ronald J. Bosch ; Louise M. Ryan ; David Wypij

Characterizing the dose‐effect relationship and estimating acceptable exposure levels are the primary goals of quantitative risk assessment. A semiparametric approach is proposed for risk assessment with continuously measured or quantitative outcomes which has advantages over existing methods by requiring fewer assumptions. The approach is based on pairwise ranking between the response values in the control group and those in the exposed groups. The work generalizes the rank‐based Wilcoxon‐Mann‐Whitney test, which for the two‐group comparison is effectively a test of whether a response from the control group is different from (larger than) a response in an exposed group. We develop a regression framework that naturally extends this metric to model the dose effect in terms of a risk function. Parameters of the regression model can be estimated with standard software. However, inference requires an additional step to estimate the variance structure of the estimated parameters. An effective dose (ED) and associated lower confidence limit (LED) are easily calculated. The method is supported by a simulation study and is illustrated with a study on the effects of aconiazide. The method offers flexible modeling of the dose effect, and since it is rank‐based, it is more resistant to outliers, nonconstant variance, and other departures from normality than previously described approaches.

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