Last update 14 Feb 2026

DEN-181

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Curcusome-RA, CurcusomeRA, CurcusomeTMRA
+ [2]
Target
VDR
Action
agonists
Mechanism
VDR agonists(Vitamin D receptor agonists)
Therapeutic Areas
Immune System DiseasesSkin and Musculoskeletal DiseasesEndocrinology and Metabolic Disease
Active Indication-
Inactive Indication
Diabetes Mellitus, Type 1Rheumatoid Arthritis
Originator Organization
Dendright Pty Ltd.Dendright Pty Ltd.
Active Organization-
Inactive Organization
Dendright Pty Ltd.Dendright Pty Ltd.
License Organization-
Drug Highest PhaseSuspendedPhase 1
First Approval Date-
Regulation-
Login to view timeline

Related

2
Clinical Trials associated with DEN-181
ACTRN12617001470381
/ WithdrawnPhase 1
A Phase I, randomised, double-blind, placebo-controlled, single centre, multiple-dose ranging study to investigate the safety, tolerability, and pharmacodynamics of subcutaneously administered DEN-181 in adult patients with ACPA+ rheumatoid arthritis on stable treatment with methotrexate.
ACTRN12617001482358
/ SuspendedPhase 1
A Phase I, randomised, double-blind, placebo-controlled, single centre, single-dose escalation study to investigate the safety, tolerability, and pharmacodynamics of subcutaneously administered DEN-181 in adult patients with ACPA+ rheumatoid arthritis on stable treatment with methotrexate.
100 Clinical Results associated with DEN-181
Login to view more data
100 Translational Medicine associated with DEN-181
Login to view more data
100 Patents (Medical) associated with DEN-181
Login to view more data
100 Deals associated with DEN-181
Login to view more data

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Rheumatoid ArthritisPhase 1
Australia
Dendright Pty Ltd.Dendright Pty Ltd.
-
Diabetes Mellitus, Type 1Preclinical
Australia
Dendright Pty Ltd.Dendright Pty Ltd.
-
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
login
or
view full example data
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
login
or
view full example data
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
login
or
view full example data
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
login
or
view full example data
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
login
or
view full example data
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
login
or
view full example data
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free